Author(s): Mayur S. Jain, Shailesh K. Koradia

Email(s): mayurjain176@gmail.com

DOI: 10.52711/2231-5691.2023.00012   

Address: Mayur S. Jain1*, Shailesh K. Koradia2
Shree Sureshadada Jain Institutes of Pharmaceutical Education and Research, Jammer, Maharashtra (India).
*Corresponding Author

Published In:   Volume - 13,      Issue - 1,     Year - 2023


ABSTRACT:
A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug which works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues. These drugs dilate the corpora cavernosa of the penis, facilitating erection with sexual stimulation, and are used in the treatment of erectile dysfunction (ED). Sildenafil was the first effective oral treatment available for ED. Because PDE5 is also present in the smooth muscle of the walls of the arterioles within the lungs, two PDE5 inhibitors, sildenafil and tadalafil, are FDA-approved for the treatment of pulmonary hypertension. As of 2019, the wider cardiovascular benefits of PDE5 inhibitors are being appreciated.


Cite this article:
Mayur S. Jain, Shailesh K. Koradia. Phosphodiesterase-5 (PDE5) Inhibitors in the Treatment of Erectile Dysfunction: A Review. Asian Journal of Pharmaceutical Research. 2023; 13(1):63-7. doi: 10.52711/2231-5691.2023.00012

Cite(Electronic):
Mayur S. Jain, Shailesh K. Koradia. Phosphodiesterase-5 (PDE5) Inhibitors in the Treatment of Erectile Dysfunction: A Review. Asian Journal of Pharmaceutical Research. 2023; 13(1):63-7. doi: 10.52711/2231-5691.2023.00012   Available on: https://asianjpr.com/AbstractView.aspx?PID=2023-13-1-12


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DOI: 10.5958/2231–5691 


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