Author(s):
Salla Pujitha, Pitla Maheshwari, M. Venkata Ramana, Akula Ganesh, Yerolla Soundarya, Neela Swathi
Email(s):
sallapujitha@gmail.com , maheshwaripitla81@gmail.com
DOI:
10.52711/2231-5691.2026.00057 
Address:
Salla Pujitha1*, Pitla Maheshwari2, M. Venkata Ramana3, Akula Ganesh4, Yerolla Soundarya5, Neela Swathi6
1Assistant Professor, Department of Pharmacology, Surabhi Dayakar Rao College of Pharmacy, JNTUH, Telangana, India.
2Student, Department of Pharmacology, Surabhi Dayakar Rao College of Pharmacy, JNTUH, Telangana, India.
3Principal, Department of Chemistry, Surabhi Dayakar Rao College of Pharmacy, JNTUH. Telangana, India.
4Associate Professor, Department of Chemistry, Surabhi Dayakar Rao College of Pharmacy, JNTUH, Telangana, India.
5Assistant Professor, Department of Pharmaceutical Analysis, Surabhi Dayakar Rao College of Pharmacy, JNTUH, Telangana, India.
6Assistant Professor, Department of Pharmaceutics, Surabhi Dayakar Rao College of Pharmacy, JNTUH, Telangana, India.
*Corresponding Author
Published In:
Volume - 16,
Issue - 4,
Year - 2026
ABSTRACT:
Purpose- The purpose of present study is to explore the anti-depressant activity of ethanolic extract of avena sativa leaves using albino mice. A common mental illness that affects 21% of people worldwide is depression. A number of adverse effects, such as heart toxicity, hypopiesia, sexual dysfunction, body weight gain and sleep disorders, can be brought on by currently used medications. The therapeutic effects of natural products on mental diseases have garnered increasing attention during the past ten years. Avena sativa was investigation for antidepressant activity. Antidepressant activity of ethanolic extract of Avena sativa (EEAS) was investigated by using Forced swimming test (FST) and Tail suspension test (TST) models. Imipramine was used as reference standards. It has been observed from our study that both the EEAS at higher concentration showed significant (p<0.01) reduction in immobility in tail suspension and forced swim model of depression comparable to Imipramine. However further study is needed to understand mechanism of action and to identify active component responsible for antidepressant like activity
Cite this article:
Salla Pujitha, Pitla Maheshwari, M. Venkata Ramana, Akula Ganesh, Yerolla Soundarya, Neela Swathi. In Vivo Evaluation of the Anti-Depressant Activity of Ethanolic Extract Avena sativa Leaves in Albino Mice. Asian Journal of Pharmaceutical Research. 2026; 16(4):391-4. doi: 10.52711/2231-5691.2026.00057
Cite(Electronic):
Salla Pujitha, Pitla Maheshwari, M. Venkata Ramana, Akula Ganesh, Yerolla Soundarya, Neela Swathi. In Vivo Evaluation of the Anti-Depressant Activity of Ethanolic Extract Avena sativa Leaves in Albino Mice. Asian Journal of Pharmaceutical Research. 2026; 16(4):391-4. doi: 10.52711/2231-5691.2026.00057 Available on: https://asianjpr.com/AbstractView.aspx?PID=2026-16-4-4
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