Author(s): C. Muralikrishna Goud, Syeda Mariya Ghazanfar

Email(s): muralikrishna1789@gmail.com

DOI: 10.52711/2231-5691.2021.00025   

Address: C. Muralikrishna Goud*, Syeda Mariya Ghazanfar
Shadan College of Pharmacy, Peerancheru, Himayatsagar Road, Hyderabad, Telangana, India, 500091.
*Corresponding Author

Published In:   Volume - 11,      Issue - 2,     Year - 2021


ABSTRACT:
The Aim of present work is to report Nimesulide a Nonsteroildal Anti Inflammatory Drug is being sold as over the counter drug has to banned completely due to occurrence of Nimesulide induced acute hepatitis. On February 12, 2011, the Union Ministry of Health and Family Welfare finally had decided to suspend the pediatric use of the Nimesulide suspension. From 10 March 2011 Nimesulide formulations are not indicated for human use in children below 12 years of age. On September 13, 2011 Madras High Court revoked a suspension on manufacture and sale of pediatric drugs Nimesulide and phenylpropanolamine (PPA). Though the government of India has banned the pediatric use of Nimesulide for common fever and pain due to its adverse effects on the liver, its usage by adults is being increased everyday without any prescription. The drug was banned in 2000 in various countries like Switzerland, Spain, United states etc, whereas in India it was banned in 2011 which was too late to be banned and still available in India for adult use despite of its hepatotoxicity and possible drug interactions.


Cite this article:
C. Muralikrishna Goud, Syeda Mariya Ghazanfar. Nimesulide – A Drug to be Banned completely. Asian Journal of Pharmaceutical Research. 2021; 11(2):132-7. doi: 10.52711/2231-5691.2021.00025

Cite(Electronic):
C. Muralikrishna Goud, Syeda Mariya Ghazanfar. Nimesulide – A Drug to be Banned completely. Asian Journal of Pharmaceutical Research. 2021; 11(2):132-7. doi: 10.52711/2231-5691.2021.00025   Available on: https://asianjpr.com/AbstractView.aspx?PID=2021-11-2-11


REFERENCES:
1.    Monica Valentovic, et al. Nimesulide. xPharm: The Comprehensive Pharmacology Reference. https://doi.org/10.1016/B978-008055232-3.62283-4
2.    aey JP. In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 inhibition by nimesulide: an overview. Inflamm Res. 1997; 46: 437–446. - PubMed
3.    Complete list of 344 drugs banned by the Ministry of Health Family welfare  https://www.nhp.gov.in/Complete-list-of-344-drugs-banned-by-the-Ministry-of-Health-Family-welfare_pg
4.    Gupta G - A Case of Nimesulide toxicity in an Indian Child. Indian Journal of Pharmacy Practice Volume 5 Issue 2 Apr - Jun, 2012.
5.    Sbeit W, Krivoy N, Shiller M, Farah R, Cohen HI, Struminger L, et al. Nimesulide-induced acute hepatitis. Annals of Pharmacotherapy. 2001;35(9):1049–52. 10.1177/106002800103500901
6.    LiverTox: Clinical and Research Information on Drug Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases, 2012 – Nimesulide, [updated 2016 Mar 1].
7.    Page M, Christin F, Hayi-Slayman D, Baillon JJ, Ber CE, Delafosse B, et al. Acute liver failure due to a treatment by nimesulide: Another case and review. Annales Francaisesd' Anesthesieet de Reanimation. 2008;27(9):742–6. 10.1016/j.annfar.2008.04.023.
8.    Rodrigo L., De Francisco R., Pérez-Pariente J.M., Cadahia V., Tojo R., Rodriguez M., Lucena M.I., Andrade R.J. Nimesulide-induced severe hemolytic anemia and acute liver failure leading to liver transplantation. Scand J Gastroenterol. 2002;37(11):1341–1343.
9.    Nimesulide-induced fatal acute liver failure in an elderly woman with metastatic biliary adenocarcinoma. A case report. Sao Paulo Med J. Jul-Aug 2015;133(4):371-6.  doi: 10.1590/1516-3180.2013.7550003. Epub 2014 Sep 19.
10.    JessyShaji and ShitalLodhaetal.Regulatory Status of Banned Drugs in India. Indian J.Pharm. Educ. Res. 44(1), Jan-Mar, 2010.
11.    Pharmaceuticals: Restrictions in use and availability https://www.who.int/medicines/areas/quality_safety/safety_efficacy/who_emp_qsm2008.3.pdf

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