Author(s): Nirmala Rangu, B. Chaitanya Kumari, Ganesh Akula, A Jaswanth

Email(s): rangunirmala@gmail.com

DOI: 10.5958/2231-5691.2018.00021.7   

Address: Nirmala Rangu1*, B. Chaitanya Kumari2, Ganesh Akula3, Dr. A Jaswanth4
1Department of Pharmaceutics, Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel (M), Siddipet (D), Telangana – 502312 (India)
2Department of Pharmaceutics, Talla Padmavathi College of Pharmacy, karreeemabad Bodrai (V), Warangal (D), Telangana – 506012 (India)
3Department of Pharmaceutical Chemistry, Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel(M), Siddipet (D), Telangana – 502312 (India)
4Department of Pharmacology, Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel (M), Siddipet (D), Telangana – 502312 (India)
*Corresponding Author

Published In:   Volume - 8,      Issue - 3,     Year - 2018


ABSTRACT:
The present study aims to formulate and evaluate oro dispersible tablets of Metoprolol, a drug that is used for the treatment of chest pain (angina) was prepared by using superdisintegration method and also optimize the best formulation. The study involved different excipients which were tested for their compatibility with Metoprolol by the FT-IR studies. Based on the results of FT-IR studies, majority of the excipients were found to be compatible with Metoprolol which were used for the preparation of Metoprolol oral disintegrating tablets. Oral disintegrating tablets of Metoprolol were prepared by direct compression method by the addition of super disintegrants. Seven batches (F1 – F7) of oral disintegrating tablets of Metoprolol were prepared by using super disintegrants like Sodium starch glycolate and Croscarmellose in variable concentrations along with other excipients for the development of optimized formulation. All the formulations were subjected to evaluation studies of weight variation, hardness, friability, drug content, Wetting time, in-vitro disintegration, in vitro-dissolution studies and are found to be within the limits.


Cite this article:
Nirmala Rangu, B. Chaitanya Kumari, Ganesh Akula, A Jaswanth. Formulation and Evaluation of Metoprolol Orodispersible Tablets by Super Disintegration Method. Asian J. Pharm. Res. 2018; 8(3):119-124. doi: 10.5958/2231-5691.2018.00021.7


Recomonded Articles:

Author(s): Sandesh Narayan Somnache, Ajeet Madhukar Godbole, Pankaj Sadashiv Gajare, Sapna Kashyap

DOI: 10.5958/2231-5691.2016.00028.9         Access: Open Access Read More

Author(s): Rutuja S. Shah, Rutuja R. Shah, Manoj M. Nitalikar, Chandrakant S. Magdum

DOI: 10.5958/2231-5691.2017.00028.4         Access: Open Access Read More

Author(s): Mukul Ahmed, Ravikumar, Narayanaswamy VB, Injamamul Haque, Mohibul Hoque

DOI: 10.5958/2231-5691.2016.00020.4         Access: Open Access Read More

Author(s): Bhushan P. Gayakwad, Shashikant D. Barhate, Mayur S. Jain

DOI: 10.5958/2231-5691.2017.00039.9         Access: Open Access Read More

Author(s): Injamamul Haque, Ravikumar, Narayanaswamy VB, Mohibul Hoque

DOI: 10.5958/2231-5691.2016.00023.X         Access: Open Access Read More

Author(s): Dasari Nirmala, Swapna Nandhini, M. Sudhakar

DOI: 10.5958/2231-5691.2016.00012.5         Access: Open Access Read More

Author(s): Rutuja S. Shah, Rutuja R. Shah, Manoj M. Nitalikar, Chandrakant S. Magdum

DOI: 10.5958/2231-5691.2017.00024.7         Access: Open Access Read More

Author(s): Dilip M. Kumbhar, Vijay D. Havaldar, Kailas K. Mali, Remeth J. Dias, Vishwajeet S. Ghorpade, Rahul B. Londhe

DOI: 10.5958/2231-5691.2017.00002.8         Access: Open Access Read More

Author(s): Shiv Kumar Gupta, Anuradha Singh, Babita Kumar, Bharti Sharma

DOI: 10.5958/2231-5691.2017.00012.0         Access: Open Access Read More

Author(s): Girish Pai K., Vamshi Krishna T., Lalit Kumar, M. Sreenivasa Reddy, G. Shreenidhi, A. Praneeth Reddy

DOI:         Access: Open Access Read More

Author(s): Priyanka Joshi, Manju, Mohd Vaseem Fateh, N.G. Raghavendra Rao

DOI: 10.5958/2231-5691.2019.00008.X         Access: Closed Access Read More

Author(s): Uma Sankar Gorla,. M. Savithri, G.S.N. Koteswara Rao,. Y. Niharika, . P. Devi Sree Sathya, . V. Harika

DOI: 10.5958/2231-5691.2018.00006.0         Access: Open Access Read More

Author(s): Prakash Goudanavar, Doddayya Hiremath, Spandana D. , S. R. Reddy

DOI:         Access: Open Access Read More

Author(s): Ashok Thulluru, Nawaz Mahammed, C. Madhavi, K. Nandini, S. Sirisha, D. Spandana

DOI: 10.5958/2231-5691.2019.00016.9         Access: Closed Access Read More

Author(s): Sugiyartono, Tutiek Purwanti, Isnaeni, Dhenok Reso Fenda Asega

DOI:         Access: Open Access Read More

Author(s): Gawai Mamata N., Aher Smita S, Saudager Ravindra B.

DOI:         Access: Open Access Read More

Asian Journal of Pharmaceutical Research (AJPRes.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. AJPRes. publishes Original Research Articles, Short Communications..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231–5691 


Recent Articles




Tags