Author(s): Mukul Ahmed, Ravikumar, Narayanaswamy VB, Injamamul Haque, Mohibul Hoque

Email(s): ravikumar300@gmail.com

DOI: 10.5958/2231-5691.2016.00020.4   

Address: Mukul Ahmed1, Ravikumar2*, Narayanaswamy VB3, Injamamul Haque1, Mohibul Hoque4
1M.Pharm (Pharmaceutics), Research Scholar, Karavali College of Pharmacy, Mangalore
2Department of Pharmaceutics, Karavali College of Pharmacy, Mangalore
3Department of Pharmacognosy, Karavali College of Pharmacy, Mangalore
4Department of Pharmacology, Karavali College of Pharmacy, Mangalore
*Corresponding Author

Published In:   Volume - 6,      Issue - 3,     Year - 2016


ABSTRACT:
The objective of this research was to formulate fast dissolving tablets of Doxazosin mesylate that disintegrate in the oral cavity upon contact with saliva and there byimprove therapeutic efficacy. Doxazosin mesylate is used for the treatment of the signs and symptoms of benign Prostatic Hyperplasia. Fast dissolving tablets ofDoxazosin mesylate were prepared by direct compression method using superdisintegrant addition method, by using sublimation method and effervescent method. Thirty two formulations were prepared and evaluated for hardness, thickness, friability, weight variation, drug content, in vitro disintegration time, in vitro dispersion time, wetting time, water absorption ratio and in vitro dissolution studies. FTIR and DSC studies revealed that there was no chemical interaction between the drug and the excipients. Formulation S8 was found to be the best on the basis of wetting time, in vitro disintegration time and in vitro drug release. The formulation S8containing camphor (8%) as subliming agent was found to be the optimized combinations. Stability studies were carried out at 250C±20C/60%±5% RH and400C±20C/75%±5% RH for formulation S8 for 60 days. The results of stability studies indicated no significant changes with respect to physicochemical properties, in vitro disintegration time, wetting time and in vitro drug release.


Cite this article:
Mukul Ahmed, Ravikumar, Narayanaswamy VB, Injamamul Haque, Mohibul Hoque. Formulation and Evaluation of Fast Dissolving Tablets of Doxazosin Mesylate. Asian J. Pharm. Res. 2016; 6(3): 131-146. doi: 10.5958/2231-5691.2016.00020.4


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Asian Journal of Pharmaceutical Research (AJPRes.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. AJPRes. publishes Original Research Articles, Short Communications..... Read more >>>

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DOI: 10.5958/2231–5691 


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