Author(s): Injamamul Haque, Ravikumar, Narayanaswamy VB, Mohibul Hoque

Email(s): ravikumar300@gmail.com

DOI: 10.5958/2231-5691.2016.00023.X   

Address: Injamamul Haque1*, Ravikumar2*, Narayanaswamy VB3, Mohibul Hoque4
1M.Pharm (Pharmaceutics), Research Scholar, Karavali College of Pharmacy, Mangalore
2Department of Pharmaceutics, Karavali College of Pharmacy, Mangalore
3Department of Pharmacognosy, Karavali College of Pharmacy, Mangalore
4Department of Pharmacology, Karavali College of Pharmacy, Mangalore
*Corresponding Author

Published In:   Volume - 6,      Issue - 3,     Year - 2016


ABSTRACT:
Montelukast sodium is an anti-asthmatic, mainly prevents leukotriene mediated effect associated with asthma. Mouth dissolving tablets of montelukast sodium was prepared by direct compression method using superdisintegrants such as croscarmellose sodium, crospovidone and sodium starch glycolate. Mouth dissolving tablets (MDTs) disintegrates or dissolves rapidly without water within few seconds in the mouth due to the action of superdisintegrants or maximizing pore structure in the formulation. The tablets were prepared using various diluents like MCC, Lactose and superdisintegrants namely Crosscarmellose sodium, Crosspovidone and Sodium starch glycollate in different concentrations. Pre-compression parameters such as angle of repose, bulk density, tapped density, compressibility index, Hausner’s ratio were carried out to study the flow properties of powder to achieve uniformity of tablet weight and the values were within permissible limits.The prepared tablets were evaluated for hardness, thickness, weight variation, friability, % drug content, wetting time, water absorption ratio, in vitro disintegration time, in vitro dispersion time and in vitro drug release.The formulation M12 and L12 was found to be the best on the basis of wetting time, in vitro disintegration time and in vitro drug release. Stability studies were carried out at 250C ± 20C / 60% ± 5% RH and 400C ± 20C / 75% ± 5% RH for a period of 60 days for the selected formulations. The formulation M12 and L12 containing Crospovidone (8%) as superdisintegrant and microcrystalline cellulose and lactose as diluents was respectively found to be the optimized combination.


Cite this article:
Injamamul Haque, Ravikumar, Narayanaswamy VB, Mohibul Hoque. Formulation and Evaluation of Montelukast Sodium Fast Dissolving Tablets. b. Asian J. Pharm. Res. 2016; 6(3): 159-169. doi: 10.5958/2231-5691.2016.00023.X


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DOI: 10.5958/2231–5691 


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