Orally disintegrating tablets are an emerging trend in novel drug delivery system and have received ever increasing demand during the last few decades. Orally disintegrating tablets ODTs are the dosage form which will disintegrate in mouth within seconds without need of water. This type of property in dosage form can be attained by addition of different varieties of excipients. But the number of fillers/binders/disintegrant which can be used for ODT formulations is limited because these bulk excipients have to fulfill special requirements, such as being soluble in water, pleasant taste, mouth feel, sweetness, and rapid dispersibility. In recent years drug formulation scientists have recognized that single component excipients do not always provide the requisite performance to allow certain active pharmaceutical ingredients to be formulated or manufactured adequately. New combinations of existing excipients are an interesting option for improving excipient functionality now a day. In excipients mannitol is used as diluents but now a day’s modified mannitol is available which give extensive flow, compression and rapid dispersibility to the tablet e.g. like Orocell, Mannogem EZ, and Pearlitol SD 200. The current review article is prepared to have a look over the recent development in excipient technology and the approaches involved in development of such excipients. It emphasizes on the different examples of functionality added materialsalso called as multifunctional co processed excipients available in market such as Ludiflash, Pharmburst, and F- MELT.
Cite this article:
Sanjay S. Patel, Siddhi V. Shah. Overview on Functionality Added Co-processed Excipients for Orodispersible Tablets. Asian Journal of Pharmaceutical Research 2022; 12(4):323-4. doi: 10.52711/2231-5691.2022.00052
Sanjay S. Patel, Siddhi V. Shah. Overview on Functionality Added Co-processed Excipients for Orodispersible Tablets. Asian Journal of Pharmaceutical Research 2022; 12(4):323-4. doi: 10.52711/2231-5691.2022.00052 Available on: https://asianjpr.com/AbstractView.aspx?PID=2022-12-4-11
1. Vishali T, Damodharan N. Orodispersible Tablets: A Review. Research J. Pharm. and Tech 2020;13(5):2522-2529.
2. Fady A. Malaak, Khalid Abu Zeid, Shahinaze A. Fouad, Mohamed A. El-Nabarawi. Orodispersible Tablets: Novel Strategies and future challenges in Drug Delivery. Research J. Pharm. and Tech. 2019;12(11):5575-5582.
3. Gohel MC, Jogani PD. A review of Co-processed Directly Compressible Excipients. J. Pharm. Pharmaceutics Sci. 2005;8(1):76-93.
4. Patel SS, Patel PM, and Patel NM, Evaluation of direct-compression characteristics of co-processed Lactose using Nimesulide. The Indian Pharmacist. 2008;(7)75:73-80.
5. Tapan Kumar Giri, Dulal Krishna Tripathi, Rana Majumdar. Orodispersible Tablets: An Overview of Taste-masking and Evaluation Techniques. Research J. Pharma. Dosage Forms and Tech. 2010; 2(3): 225-232.
6. Patel SS, Patel NM, Development of directly compressible co-processed excipients for dispersible tablets using 3² full factorial designs. Int. J. Pharma. Sci. 2009;1(1):125-148.
7. Jaybhaye Aarti, Joshi Sonali, Deshmukh Ganesh. Orodispersible Tablets: A Comprehensive Review. Research J. Pharm. and Tech. 2014; (3):368-375.
8. Abdul Sayeed, Hamed M., Mohd Rafiq. Formulation and In vitro Evaluation of Mouth Dissolving Tablets of Carvedilol by Direct Compression Methods. Research J. Pharm. and Tech. 2012;5(12):1525-1531.
9. Prashant N, Sheeja K, Coprocessed Excipients for Orally Disintegrating Dosage Form, International Journal of Pharma Research & Review. 2014;3(4):95-100.
10. Patel SS, Patel MS, Patel NM. Flowability testing of directly compressible excipients according to British pharmacopoeia. J. of Pharm. Research. 2009;(8):66-69.
11. Rajni B, Sushil K, Pravin P. Polymers In Fast Disintegrating Tablets – A Review, Asian J. Pharm. Clinical Research. 2012;5(2):9-14.
12. Westerhuis P, De Haan B, Zwinkels J, Jansen WT, Coenegracht PJM, Lerk CF. Optimisation of the composition and production of mannitol/microcrystalline cellulose tabletsd. International J. Pharm.1996;143:151-162.
13. SC Jagdale, AR Chabukswar, BS Kuchekar, AN Padalkar, AU Kale. Comparative Evaluation of Superdisintegrants with Formulation Development of Orodispersible Tablets of Mosapride Citrate Dihydrate. Research J. Pharm. and Tech. 2009;2(1): 91-96.
14. Rajashree M, Kokate, and V. Shah, Development of Orodispersible Tizanidine HCl Tablets Using Spray Dried Coprocessed Excipient Bases. Indian J. Pharm. Sciences, 2011;73(4):392-396.
15. Gohel MC, Patel TM, Parikh RK, Parejiya1 PB, Barot BS, and Ramkishan A. Exploration of Novel Co‑processed Multifunctional Diluent for the Development of Tablet Dosage Form. Indian J. Pharm. Sciences, 2012;74(5):381-386.
16. Aris Perdana Kusuma, Achmad Fudholi, Akhmad Kharis Nugroho. Optimization Direct Compression’s Co-Processed Excipient Microcrystalline Cellulose PH102 and Povidone® K30. IOSR Journal of Pharmacy and Biological Sciences. 2014;9(2):65-69.
17. Gohel MC, Parikh RK., Brahmbhatt BK, and Shah AR. Improving the Tablet Characteristics and Dissolution Profile of Ibuprofen by Using a Novel Coprocessed Superdisintegrant: A Technical Note. AAPS Pharm SciTech. 2007;8 (1):1-6.
18. K Olowosulu1, Avosuahi Oyi, Isah AB, Ibrahim MA. Formulation and Evaluation of Novel Co-processed Excipients of Maize Starch and Acacia Gum (StarAc) For Direct Compression Tableting. Int. J. Pharm. Research and Innovation. 2011;2:39-45.
19. Sujathakumari M, Prasanthi, Sudha Bhargavi, M Praveenakumari, Ushasri S. Reassessment of novel co-processed multifunctional excipients. Int. Res. J. Pharma. App Sci. 2013;29(4):122-128.