ISSN
2231-5691 (Online) 2231-5683 (Print)
Author(s): Rutuja S. Shah, Rutuja R. Shah, Manoj M. Nitalikar, Chandrakant S. Magdum
Email(s): rutujashah557422@gmail.com
DOI: 10.5958/2231-5691.2017.00028.4
Address: Rutuja S. Shah, Rutuja R. Shah, Manoj M. Nitalikar, Chandrakant S. Magdum Department of Pharmaceutics, Rajarambapu College of Pharmacy, Kasegaon, Tal- Walwa, Dist-Sangli-415404 *Corresponding Author
Published In: Volume - 7, Issue - 3, Year - 2017
ABSTRACT: A major challenge in the drug development and delivery process is improving aqueous solubility and rate of dissolution of drugs, which ultimately improves absorption of the drug. Bicalutamide is most useful drug in prostate cancer treatment it is a non-steroidal antiandrogen. It comes under class of poorly water-soluble drug. Poor water-solubility of drugs leads to slow drug absorption, and low bioavailability, for which its solubility is to be enhanced to improve the oral bioavailability of the. One of the possible way to overcome this outcome is to use formulate solid dispersion by using spray drying technique. Spray-drying is a unit operation by which a liquid product is atomized in a hot gas current to instantaneously obtain a powder. The purpose of this research was to improve the solubility profile of Bicalutamide by spray drying technique using Methanol and Polyvinyl pyrolidone-K30. Prepared solid dispersions were evaluated for drug release profile. The compatibility was studied by Fourier Transforms Infrared spectroscopy (FTIR). Prepared Microspheres were subjected to various physicochemical evaluations and in-vitro dissolution profile. The effects of different concentrations of polymer on Solubility enhancement were studied.
Cite this article: Rutuja S. Shah, Rutuja R. Shah, Manoj M. Nitalikar, Chandrakant S. Magdum. Microspheres by Spray Drying: An Approach to Enhance Solubility of Bicalutamide. Asian J. Pharm. Res. 2017; 7(3): 183-188. doi: 10.5958/2231-5691.2017.00028.4
Author(s): Hiral A. Makadia, Ami Y. Bhatt, Ramesh B. Parmar, Ms. Jalpa S. Paun, H.M. Tank
DOI: Access: Open Access Read More
Author(s): Prajapati M., Mandloi R., Pillai S, Birla N.
DOI: 10.5958/2231-5691.2020.00021.0 Access: Closed Access Read More
Author(s): Sandesh Narayan Somnache, Ajeet Madhukar Godbole, Pankaj Sadashiv Gajare, Sapna Kashyap
DOI: 10.5958/2231-5691.2016.00028.9 Access: Open Access Read More
DOI: 10.5958/2231-5691.2017.00028.4 Access: Open Access Read More
Author(s): Mukul Ahmed, Ravikumar, Narayanaswamy VB, Injamamul Haque, Mohibul Hoque
DOI: 10.5958/2231-5691.2016.00020.4 Access: Open Access Read More
Author(s): Rita N. N. Rammo
DOI: 10.5958/2231-5691.2017.00005.3 Access: Open Access Read More
Author(s): Injamamul Haque, Ravikumar, Narayanaswamy VB, Mohibul Hoque
DOI: 10.5958/2231-5691.2016.00023.X Access: Open Access Read More
DOI: 10.5958/2231-5691.2017.00024.7 Access: Open Access Read More
Author(s): Vidya Dange , Shubhangi Shid, C.S. Magdum ,S.K. Mohite, M.M. Nitalikar
DOI: 10.5958/2231-5691.2015.00032.5 Access: Open Access Read More
Author(s): Dasari Nirmala, Swapna Nandhini, M. Sudhakar
DOI: 10.5958/2231-5691.2016.00012.5 Access: Open Access Read More
Author(s): B.A. Bhairav, J.K. Bachhav, R.B. Saudagar
DOI: 10.5958/2231-5691.2016.00025.3 Access: Open Access Read More
Author(s): Bijay Kumar Sahoo, Sidheswar Prasad Pattajoshi, Sandhyarani Pattajoshi
DOI: 10.5958/2231-5691.2018.00011.4 Access: Open Access Read More
Author(s): Varsha A. Dighe, Rohini R. Pujari
DOI: 10.5958/2231-5691.2017.00004.1 Access: Open Access Read More
Author(s): N. M. Vageesh, Ramya Sri Sura, K Gulijar Begum, B Swathi
DOI: 10.5958/2231-5691.2017.00029.6 Access: Open Access Read More
Author(s): S. M. Ragade, M. M. Bari, S. D. Barhate
DOI: 10.5958/2231-5691.2018.00024.2 Access: Open Access Read More
Author(s): Dilip M. Kumbhar, Vijay D. Havaldar, Kailas K. Mali, Remeth J. Dias, Vishwajeet S. Ghorpade, Rahul B. Londhe
DOI: 10.5958/2231-5691.2017.00002.8 Access: Open Access Read More
Author(s): Kaustubh V. Gavali, Manohar D. Kengar, Kiran V. Chavan, Vaishnavi P. Anekar, Naziya I. Khan
DOI: 10.5958/2231-5691.2019.00020.0 Access: Closed Access Read More
Author(s): P. K. Wagh, S. P. Ahirrao, S. J. Kshirsagar
DOI: 10.5958/2231-5691.2019.00013.3 Access: Closed Access Read More
Author(s): Ashok Thulluru, Nawaz Mahammed, C. Madhavi, K. Nandini, S. Sirisha, D. Spandana
DOI: 10.5958/2231-5691.2019.00016.9 Access: Closed Access Read More
Author(s): Indrajeet S. Patil, Omkar A. Patil, Girish Chandra R. Mandake, Manoj M. Nitalikar
DOI: 10.5958/2231-5691.2018.00035.7 Access: Closed Access Read More
Asian Journal of Pharmaceutical Research (AJPRes.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. AJPRes. publishes Original Research Articles, Short Communications..... Read more >>>
Pharmaceutical Importance and Significance of Limit Tests
Computer-Based Marketing Analysis: A Review
Screening Models for CNS Stimulant Drugs: A Review
Form Fill Seal Technology: A Brief Review
Banned Drugs: A Review
Ethnobotanical study on Medicinal Plants used by Traditional Health Practitioners and Villagers of Garhphulghar Gram, Chhattisgarh, India
Self-nano Emulsifying Drug Delivery System (SNEDDS): Future Aspects
The Review on The Nasal Drug Delivery
An Efficient Synthesis of Rabeprazole Sodium
Significance of Pharmaceutical Excipients on Solid Dosage form Development: A Brief Review
The Survey of Knowledge about OTC Drugs among Pharmacy Background and Non-Pharmacy Community
Formulation and Evaluation of Cinitapride Controlled Release Tablets
Reverse Logistic Practices on Household Medical Disposal in India and its Impacts on Environment
Generic Vs. Brand Medicines: An Overview
Microspheres by Spray Drying: An Approach to Enhance Solubility of Bicalutamide