Author(s): Sandesh Narayan Somnache, Ajeet Madhukar Godbole, Pankaj Sadashiv Gajare, Sapna Kashyap

Email(s): sandeshsomnache@gmail.com

DOI: 10.5958/2231-5691.2016.00028.9   

Address: Sandesh Narayan Somnache1*, Ajeet Madhukar Godbole1, Pankaj Sadashiv Gajare1, Sapna Kashyap2
1Department of Pharmaceutics, PES’S Rajaram and Tarabai Bandekar College of Pharmacy, Farmagudi, Ponda-403401, Goa, India.
2Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh, India.
*Corresponding Author

Published In:   Volume - 6,      Issue - 3,     Year - 2016


ABSTRACT:
The rapid and vibrant growth of pharmaceutical industries leads to newer challenges in field of formulation development. With the launch of new Active Pharmaceutical Ingredients and also the excipient possessing different physicochemical properties, it is really a challenging task for a formulation scientist in presenting a viable, suitable and stable dosage formulation. Many failures in pharmaceutical formulation manufacturing processes are caused due to issues related to Pharmaceutical excipients. Selection of wrong excipient not only affects the physicochemical properties of dosage form but also affect the biopharmaceutical characters. Along with drug excipient incompatibilities, improper ratio of excipients, particle characters including molecular and bulk characters of excipients affect the dosage form characters. Thus in current review, the significance of various properties of excipient on the physicochemical and biological behavior of dosage form and the criteria for selection of excipients in designing of robust formulation is summarized. Disintegrating agents and lubricating agents are the excipients, although required in very small proportion, but their physicochemical characters and ratio in formulation highly affects the formulation properties. Thus, in current review special emphasis is given on the effect of disintegrating agents and lubricating agents on the characteristics of tablet dosage form.


Cite this article:
Sandesh Narayan Somnache, Ajeet Madhukar Godbole, Pankaj Sadashiv Gajare, Sapna Kashyap. Significance of Pharmaceutical Excipients on Solid Dosage form Development: A Brief Review. Asian J. Pharm. Res. 2016; 6(3): 193-202. doi: 10.5958/2231-5691.2016.00028.9


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DOI: 10.5958/2231–5691 


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