Volume No. :   9

Issue No. :  4

Year :  2019

ISSN Print :  2231-5683

ISSN Online :  2231-5691


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Schiff bases and Bicyclic derivatives comprising 1, 3, 4-thiadiazole moiety- A Review on their Pharmacological activities



Address:   Sherin A. Hameed1, Joyamma Varkey2, P. Jayasekhar3
1College of Pharmaceutical Sciences, Govt. Medical College, Thiruvananthapuram-695011
2College of Pharmaceutical Sciences, T.D Medical College, Alappuzha-688005
3College of Pharmacy, National University of Science and Technology, Muscat, Oman
*Corresponding Author
DOI No: 10.5958/2231-5691.2019.00047.9

ABSTRACT:
1, 3, 4-thiadiazole is a well-known heterocyclic nucleus which form an integral feature of various natural products and medicinal agents. It has enormous biological potential due to their privileged structure and is able to undergo various chemical reactions which make researcher more comfortable in drug designing. The stability of thiadiazole nucleus has inspired medicinal chemist to carryout various structural variations in the ring. This review highlights the pharmacological activity of recently synthesized Schiff bases and fused ring systems comprising1,3,4- thiadiazole moiety.
KEYWORDS:
1, 3, 4-thiadiazole, Schiff bases, triazolothiadiazole, antimicrobial activity, anticonvulsant activity, antioxidant activity, anticancer activity, antidiabetic activity, antidepressant activity.
Cite:
Sherin A. Hameed, Joyamma Varkey, P. Jayasekhar. Schiff bases and Bicyclic derivatives comprising 1, 3, 4-thiadiazole moiety- A Review on their Pharmacological activities. Asian J. Pharm. Res. 2019; 9(4):299-306.
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