Author(s):
Prajakta P Shinde, Shahu D Khule, Sneha Sonawane, Suvarna Shelke
Email(s):
pp_shinde123@rediffmail.com
DOI:
10.52711/2231-5691.2021.00027 
Address:
Prajakta P Shinde1*, Shahu D Khule2, Sneha Sonawane3, Suvarna Shelke4
1Assistant Professor, SMBT College of Pharmacy, Dhamngaon, Igatpuri, Nashik-422403.
2QA Executive, GSK, Pharmaceutical, Nashik.
3Assistant Professor, SMBT College of Pharmacy, Dhamngaon, Igatpuri, Nashik-422403.
4Assistant Professor, SMBT College of Pharmacy, Dhamngaon, Igatpuri, Nashik-422403.
*Corresponding Author
Published In:
Volume - 11,
Issue - 3,
Year - 2021
ABSTRACT:
India has rich heritage of use of medicinal plants in clinical practices since ancient times. Diabetes mellitus is a group of syndromes characterized by hyperglycemia, altered lipid, carbohydrate and protein metabolism, and an increased risk of vascular disease complications. More than 400 plant species have been recorded to display hypoglycemic effects, but only a few of them have been investigated. Although many drugs are available to control the diabetes but has several adverse effects. The plant Sida cordata activities have been reported such as Antibacterial, Antitumor, Antifungal, Antiulcer, Antitussive, Anti-inflammatory, Anti-malarial, Anti-oxidant, Analgesic, Antidepressant, Antihyperglycemic, Hepatoprotective in ayurvedic system of medicine. This research was conducted undertaken In order to investigate the anti-diabetic activity of methnolic extract of Sida cordata. The two dose (100 and 200 mg/kg) methnolic extract of Sida cordata used for treatment of Alloxan induced diabetic rats. The glucose level was significantly (p<0.01) high in Alloxan control rats when opposed to normal control. But the level of glucose was significantly (p<0.01) decreased after 7th day in diabetic rats treated with methanol extract (200 mg/kg) as compared with diabetic control rats.
Cite this article:
Prajakta P Shinde, Shahu D Khule, Sneha Sonawane, Suvarna Shelke. Analgesic activity and anti-inflammatory activity of methanolic extract of plant Sida cordata in carrageenan-induced paw edema in rats. Asian Journal of Pharmaceutical Research. 2021; 11(3):143-6. doi: 10.52711/2231-5691.2021.00027
Cite(Electronic):
Prajakta P Shinde, Shahu D Khule, Sneha Sonawane, Suvarna Shelke. Analgesic activity and anti-inflammatory activity of methanolic extract of plant Sida cordata in carrageenan-induced paw edema in rats. Asian Journal of Pharmaceutical Research. 2021; 11(3):143-6. doi: 10.52711/2231-5691.2021.00027 Available on: https://asianjpr.com/AbstractView.aspx?PID=2021-11-3-1
REFERENCES:
1. K. R., Basu B. D., Indian Medicinal Plants, International Book Distributors, Deharadun, India, Text Vol. I, 302- 304, 306-314.
2. PDR for herbal medicine, Thomson Publication, 4th Edition, 3-4.
3. Agrawal SS, M Paridhavi, “Herbal Drug Technology”, University Press, 1-25.
4. Kokate CK, Purohit AP and S. B. Gokhale. Pharmacognosy, Nirali Prakashan Publications. 28th Edition, 1.4-1.8.
5. Robbin’s and Cotran’s “Pathology Basis of Disease. 18th Edition: pp. 853, 891, 1139-1146.
6. Ross and Wilson’s. Anatomy and Physiology In Health and Illness, 11th Edition: pp .299-300, 300-303.
7. Lippincotts, “Illustrated Review of Pharmacology”, 225-257.
8. Diabetes Mellitus, David Squirrell, Spr Ophthalmology Royal Hallamshire Hospital Sheffield, Judith Bush General Practitioner and Clinical Assistant in Ophthalmology, 1-33.
9. T. Pullaiah, K. et al., Antidiabetic plants in India and herbal based antidiabetic research, A database on anti-diabetic plants, 129
10. D. Gnanasekaran, et al, Adaptogenic Activity of A Siddha Medicinal Plant: Sida cordata, International Journal Of Pharmaceutical And Biomedical Research, 2012, ISSN No: 0976-0350.
11. Sandhya.S, et al, Plants as a potent anti-diabetic and wound healing agents – A review, Hygeia, Journal for Drugs and Medicines, Vol.3, 2011, 11-19.
12. D. Gnanasekaran, et al, In vitro hepatoprotective activity of a selected siddha medicinal plant Sida cordata using chang liver cells, Research article, Jan 2012, ISSN: 2249-3384.
13. Trease and Evans, “A Text Book Of Pharmacognosy”, 449-452.
14. M. Ramakrishnan, et al., Hypoglycemic activity of Coccinia indica Wight & Arn. Fruits in Alloxan-induced diabetic rats, Indian Journal of Natural Products and Resources, 2011; Vol. 2(3): 350-353.
15. A. K. M. M. Rahman, et al, Three New Flavonol C-Glycosides from Sida cordifolia Linn, Journal of the Iranian Chemical Society 2007; Vol. 4: 175-181.
16. Ghanekar BG. Sutrasthana. In: Sushrut Samhita. Varanasi: Motilal Banarasidas; 1981. pp. 3.
17. K. Chandra, BG. Chaudhari, BP. Dhar, Joseph JV, Mangal AK, R. Dabur, et al. Database on medicinal plants used in Ayurveda. Cent Counc Res Ayurveda Siddha 2007;8: pp.42-58.
18. EM. Franzotti, CV. Santos, HM. Rodrigues, RH. Mourão, MR. Andrade, AR. Antoniolli. et.al Anti-inflammatory, analgesic activity and acute toxicity of Sida cordifolia L. (Malva-branca). J Ethnopharmacol 2000; 72(1-2) :pp.273-7.
19. Singh A, Malhotra S and Subban R et al: Anti-inflammatory and analgesic agents from Indian Medicinal Plants, International J. of Integrative Biology 2008; Vol 3,57-72
20. Gunatilaka AAL, Sotheeswaran S, Balasubramaniam S, Chandrasekara AI, Badrasriyani HT et al. Studies on medicinal plants of Sri Lanka. Planta Med 1980; 39: pp.66-72.
21. Obadoni BO, Ochuko PO. Phytochemical studies and comparative efficacy of the crude extract of some homeostatic plantsin Edo and Delta states of Nigeria”. Global J Pure Appl Sci 2001; Vol.: pp.203-208.
22. Bohm BA, Kocipai Abyazan R. Flavonoid and condensed tannins from the leaves of Vaccinum raticulation and Vaccinum calcyimium. Pacific Sci 1994; Vol. 48:pp.458-463
23. Zafar R, Lalwani M. Tribulus terrestris Linn. A review of current knowledge”, Indian Drugs 1989:2Vol (3):pp.148- 158
24. Doss A. 2009. Preliminary phytochemical screening of some Indian Medicinal Plants. Anc Sci Life, 29Vol.(2): pp.12‐16.
25. Sutradhar RK, Rahman AK, Ahmad MU, Bachar SC, Saha A, Guha SK. et.al Bioactive alkaloid from Sida cordifolia Linn. With analgesic and anti-inflammatory activities. Iran J Pharmacol Ther 2006; Vol 5(2):pp. 175-8