Evaluation and Development of Osmotic drug delivery of venlafaxine Hydrochloride Tablet

Jyotir Patel

Asian Journal of Pharmaceutical Research

ISSN

2231-5691 (Online)
2231-5683 (Print)

Submit Article

Evaluation and Development of Osmotic drug delivery of venlafaxine Hydrochloride Tablet

Author(s): Jyotir Patel

Email(s): Email ID Not Available

DOI: Not Available

Address: Jyotir Patel*
Department of Pharmacy, Shri Jagdish Prasad Jhabarmal Tibrewala University, Vidyanagari, Jhunjhunu, Rajasthan, India
*Corresponding Author

Published In: Volume - 3, Issue - 2, Year - 2013

View HTML

View PDF

ABSTRACT:
Osmotic systems utilizes the principle of osmosis for delivery of drug. It is advantageous that drug release from the osmotic devices independent of physiological environment and pH. Drug release can be optimized to zero order release rate by modifying formulation properties. Venlafaxine Hydrochloride(VH), an antidepressant agent structurally unrelated to other antidepressants, is used to treat melancholia, generalized anxiety disorder (GAD), panic disorder, post-traumatic stress disorder, and hot flashes in breast cancer survivors. Absolute bioavailability is 45% and a single oral dose is well absorbed (at least 92%). Depressive illness generally requires long duration of drug therapy and plasma concentration substantially need to remain constant for better tolerability. Compared to Venlafaxine immediate release (IR) dosage form extended release dosage forms(ER) are well tolerated. Venlafaxine hydrochloride is highly water soluble drug(570mg/ml), so incorporation of release retardant polymers may modify release pattern for longer duration of release. Hence, it was decided to formulate CPOP of venlafaxine hydrochloride using release retardant hydrophilic polymers.

Keywords:

Cite this article:
Jyotir Patel. Evaluation and Development of Osmotic drug delivery of venlafaxine Hydrochloride Tablet. Asian J. Pharm. Res. 3(2): April- June 2013; Page 86-97.

Cite(Electronic):
Jyotir Patel. Evaluation and Development of Osmotic drug delivery of venlafaxine Hydrochloride Tablet. Asian J. Pharm. Res. 3(2): April- June 2013; Page 86-97. Available on: https://asianjpr.com/AbstractView.aspx?PID=2013-3-2-7

Recomonded Articles:

Self-nano Emulsifying Drug Delivery System (SNEDDS): Future Aspects

Author(s): Hiral A. Makadia, Ami Y. Bhatt, Ramesh B. Parmar, Ms. Jalpa S. Paun, H.M. Tank

DOI: Access: Open Access Read More

Sublingual Tablets - An Updated Review

Author(s): Ashok Thulluru, Nawaz Mahammed, C. Madhavi, K. Nandini, S. Sirisha, D. Spandana

DOI: 10.5958/2231-5691.2019.00016.9 Access: Open Access Read More

A Review on Microsphere and it’s Application

Author(s): Kaustubh V. Gavali, Manohar D. Kengar, Kiran V. Chavan, Vaishnavi P. Anekar, Naziya I. Khan

DOI: 10.5958/2231-5691.2019.00020.0 Access: Open Access Read More

The Review on The Nasal Drug Delivery

Author(s): Prajapati M., Mandloi R., Pillai S, Birla N.

DOI: 10.5958/2231-5691.2020.00021.0 Access: Open Access Read More

Review on Solubility Enhancement Techniques

Author(s): B.A. Bhairav, J.K. Bachhav, R.B. Saudagar

DOI: 10.5958/2231-5691.2016.00025.3 Access: Open Access Read More

A Review- Nanosuspension Technology in Drug Delivery System

Author(s): Sarika V. Khandbahale

DOI: 10.5958/2231-5691.2019.00021.2 Access: Open Access Read More

A Review on New Herbal Remedies for treatment of Mouth Ulcer

Author(s): Rina G. Maskare, Ayush P. Agrawal, Mayuri S. Pal, Jidnyasa R. Yerne, Megham Chaudhri, Anup R. Bawankar, Gaytri B. Sonkusre

DOI: 10.52711/2231-5691.2022.00025 Access: Open Access Read More

Microspheres by Spray Drying: An Approach to Enhance Solubility of Bicalutamide

Author(s): Rutuja S. Shah, Rutuja R. Shah, Manoj M. Nitalikar, Chandrakant S. Magdum

DOI: 10.5958/2231-5691.2017.00028.4 Access: Open Access Read More

A Review: Dry Emulsion

Author(s): Vidya Dange , Shubhangi Shid, C.S. Magdum ,S.K. Mohite, M.M. Nitalikar

DOI: 10.5958/2231-5691.2015.00032.5 Access: Open Access Read More

Formulation and Characterization of Metformin Hydrochloride Floating Tablets

Author(s): Ashok A. Hajare, Vrushali A. Patil

DOI: Access: Open Access Read More

Novel Mucoadhesive Gastro Retentive Drug Delivery System of Ranitidine Hydrochloride

Author(s): P. K. Wagh, S. P. Ahirrao, S. J. Kshirsagar

DOI: 10.5958/2231-5691.2019.00013.3 Access: Open Access Read More

Diphendramine Hydrochloride Oral Dispersible Tablets: Preparation and Evaluation

Author(s): K. Vijaya Sri, R. Harish Kumar Reddy , R. Mahesh

DOI: Access: Open Access Read More

Formulation and Evaluation of Bimolar Release of Ciprofloxacin HCl from Bilayer Gastro-Retentive Floating System.

Author(s): Bijay Kumar Sahoo, Sidheswar Prasad Pattajoshi, Sandhyarani Pattajoshi

DOI: 10.5958/2231-5691.2018.00011.4 Access: Open Access Read More

Formulation Development and In-Vitro Evaluation of Extended Release Tablets Containing Losartan Potassium

Author(s): B. Babu Rao, P. Harish, Saikat Das, T. Ashwin Kumar, V. Raman Koundinya

DOI: Access: Open Access Read More

Study on Effect of Excipients in Enhancing the Solubility of Nateglinide by Solid Dispersions

Author(s): M. Kranthi Kumar Reddy, B. Narasimha Rao, K. Ravindra Reddy

DOI: Access: Open Access Read More

Studies on Anti-depressant and Anti-inflammatory Activities of Curcuma aromatica Rhizome in Experimental Animal Models

Author(s): Jaseela KP, Anjan Kumar, Veeresh Babu. D, Narayana Swamy V.B

DOI: 10.5958/2231-5691.2016.00014.9 Access: Open Access Read More

Fast Disintegrating Tablets of Nevirapine

Author(s): Mamatha Kola, Subharna Mallik, Pranusha Palle, Pallavi Kamarapu

DOI: Access: Open Access Read More

Formulation Development and Evaluation of Gastro-Retentive Drug (Torsemide) Delivery System for Diuretic Drug

Author(s): Jagdish Jadhav, Dharmendra Mundhada, Rajesh Mujoriya

DOI: 10.5958/2231-5691.2015.00019.2 Access: Open Access Read More

A Novel Approach Towards Nanosuspension

Author(s): Rajashri R. Kulkarni, Dipti G. Phadtare, Ravindra B. Saudagar

DOI: 10.5958/2231-5691.2015.00029.5 Access: Open Access Read More

Antidepressant, Analgesic Activity and SAR Studies of Substituted Benzimidazoles

Author(s): Nadeem Siddiqui, Md Shamsher Alam, Meeta Sahu, M. Shahar Yar, Ozair Alam, Mohammad Jamshed Ahmad Siddiqui

DOI: Access: Open Access Read More

Asian Journal of Pharmaceutical Research (AJPRes.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. AJPRes. publishes Original Research Articles, Short Communications..... Read more >>>

RNI: Not Available
DOI: 10.5958/2231–5691