Liquid Crystal Gel Based Formulation: Strategies to Enhance Solubility and Absorption of Poorly Soluble Drug

Shethia Aashutosh Narendra; Sulbha G. Patil

doi:10.52711/2231-5691.2026.00053

Asian Journal of Pharmaceutical Research

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2231-5691 (Online)
2231-5683 (Print)

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Liquid Crystal Gel Based Formulation: Strategies to Enhance Solubility and Absorption of Poorly Soluble Drug

Author(s): Shethia Aashutosh Narendra, Sulbha G. Patil

Email(s): aashushethia07@gmail.com

DOI: 10.52711/2231-5691.2026.00053

Address: Shethia Aashutosh Narendra, Sulbha G. Patil
P.S.G.V.P. Mandal's college of Pharmacy Shahada (Maharashtra) Dist. Nandurbar, Maharashtra, India.
*Corresponding Author

Published In: Volume - 16, Issue - 3, Year - 2026

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ABSTRACT:
Repaglinide is a poorly water-soluble antidiabetic drug, and its low solubility limits oral bioavailability and therapeutic efficiency. The present approach focuses on the development of a repaglinide liquid crystal gel as a novel drug-delivery system to improve its solubility and dissolution characteristics. Liquid crystal gels possess an ordered internal structure capable of solubilizing lipophilic drugs and providing controlled drug release. Incorporation of repaglinide into the liquid crystalline matrix enhances its solubility, improves bioavailability, and ensures sustained release, thereby reducing dosing frequency and fluctuations in plasma drug levels. The formulation also offers good physical stability and patient acceptability. Overall, repaglinide liquid crystal gel represents a promising strategy for overcoming solubility-related limitations and improving the therapeutic performance of repaglinide in the management of type 2 diabetes mellitus.

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Cite this article:
Shethia Aashutosh Narendra, Sulbha G. Patil. Liquid Crystal Gel Based Formulation: Strategies to Enhance Solubility and Absorption of Poorly Soluble Drug. Asian Journal of Pharmaceutical Research. 2026; 16(3):363-7. doi: 10.52711/2231-5691.2026.00053

Cite(Electronic):
Shethia Aashutosh Narendra, Sulbha G. Patil. Liquid Crystal Gel Based Formulation: Strategies to Enhance Solubility and Absorption of Poorly Soluble Drug. Asian Journal of Pharmaceutical Research. 2026; 16(3):363-7. doi: 10.52711/2231-5691.2026.00053 Available on: https://asianjpr.com/AbstractView.aspx?PID=2026-16-3-21

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DOI: 10.5958/2231–5691