Nikita D. Gidde, Indrayani D. Raut, Manojkumar M. Nitalikar, Shrinivas K. Mohite, Chandrakant S. Magdum
Nikita D. Gidde*, Indrayani D. Raut, Manojkumar M. Nitalikar, Shrinivas K. Mohite, Chandrakant S. Magdum
Rajarambapu College of Pharmacy, Kasegaon (MS) India 415404.
Volume - 11,
Issue - 2,
Year - 2021
Pharmacosomes are the colloidal dispersions of drugs covalently bound to lipids and can exist, depending on the chemical structure, as ultrafine vesicular, micellar, or hexagonal aggregates. Because of the linking of a drug (pharmakon) to a carrier (soma), they are rightly termed "pharmacosomes."Pharmacosomes can be characterized as a neutral molecule with both positive and negative charges, water-loving and fat-loving characteristics, and in complex form, an ideal polyphenol-to-phospholipid ratio. Pharmacosomes are amphiphilic lipid vesicular systems that have demonstrated their ability to increase the bio-accessibility of poorly water-soluble and poorly lipophilic medicines. Drug pharmacosomes provide an effective method of delivering the drug directly to the infection site, which contributes to a lowering in drug toxicity without harmful effects, and also lowers the cost of therapy by improving the drug's bioavailability, particularly in the case of poorly soluble drugs. Pharmacosomes are appropriate to incorporate both hydrophilic and lipophilic drugs. Pharmacosomes have been designed for multiple anti-inflammatory medications that are non-steroidal, neurological, and antineoplasty.
Cite this article:
Nikita D. Gidde, Indrayani D. Raut, Manojkumar M. Nitalikar, Shrinivas K. Mohite, Chandrakant S. Magdum. Pharmacosomes as Drug Delivery System: An Overview. Asian Journal of Pharmaceutical Research. 2021; 11(2):122-7. doi: 10.52711/2231-5691.2021.00023
Nikita D. Gidde, Indrayani D. Raut, Manojkumar M. Nitalikar, Shrinivas K. Mohite, Chandrakant S. Magdum. Pharmacosomes as Drug Delivery System: An Overview. Asian Journal of Pharmaceutical Research. 2021; 11(2):122-7. doi: 10.52711/2231-5691.2021.00023 Available on: https://asianjpr.com/AbstractView.aspx?PID=2021-11-2-9
1. Thakur Sonam, Tibrewal Richa, et alPharmacosomes: An Overview, international journal of Pharmaceuticals and Biological science archive,2017; 5(2): 1-7.
2. Jangam Payal R, Thombre Nilima A, Gaikwad Pallavi N. A Review: Proniosomes as a Novel Drug Delivery System Asian J. Pharm. Tech. 2017; 7 (3): 166-174.
3. Sonam Ranga, Amit Kumar., et al A Review on Pharmacosomes. Research and Reviews: Journal of Pharmaceutics and Nanotechnology, 2014; 2(1): 8-14
4. Selvaraju K., Vengadesh Prabhu K., Karthick K., Padma Preetha J. and Arul Kumaran K.S.G. Pharmacosomes- An Immense Potential Vesicular Constructs Research J. Pharma. Dosage Forms and Tech. 2011; 3(3): 84-86.
5. Nagasamy V. D, Kalyani K, Tulasi K, Swetha P, Shaik A. A, et alPharmacosomes: a potential vesicular drug delivery system, International Journal of Pharmaceutical Science and Drug Research. 2014; 6(2): 90-94.
6. Pavan Kumar, Debnath S, Babu N et al “Pharmacosomes as a novel vesicular drug delivery system”, Int J of Novel Trends in Pharm. Sci.2013; 3(3): 46- 52.
7. D. Nagasamy Venkatesh, K. Kalyani, K. Tulasi, V. Swetha Priyanka, Shaik Abid Ali, S. Shashi Kumar, et alPharmacosomes: A Potential Vesicular Drug Delivery System; International Journal of Pharmaceutical Sciences and Drug Research 2014; 6(2): 91-92
8. PreetiKhulbe, Deepa Mohan Rajput, Tahseen Khan et alPharmacosomes: An Effective Approach for Drug Delivery; SGVU Journal of Pharmaceutical Research and Education, 2019; 4(1): 352-358
9. Mantelli S, Speiser P, Hauser H. et al Phase behaviour of a diglyceride prodrug: spontaneous formation of unilamellar vesicles Chem. Phys Lipids 1985; 37: 329–343.
10. P. H. Sharma, P. V. Powar, S. S. Sharma et alPharmacosomes: A novel drug delivery system; The Pharma Innovation Journal 2014; 3(10): 94-100
11. Drug carrier Wikipedia, sevenson, sonke, carrier based drug delivery, 2004.
12. Biju SS, Talegaonkar S, Mishra PR, Khar KR. Vesicular System: An overveiw. Indian J. Pharm Sci, 2009; 71(4): 421-427.
13. Bommala Supraja, Saritha Mullangi, An updated review on pharmacosomes, a vesicular drug delivery system, Journal of Drug Delivery and Therapeutics. 2019; 9(1-s): 393-402
14. Solanki D, Patidar A, Kukde D, Pharmacosomes – A Review, International Journal of Pharmacy, Eng and Life Sci. 2016; 12(3): 70-78.
15. Lawrence MJ. Surfactant Systems: Their use in drug delivery. Chem Soc Rev, 1994; 23: 417–424.
16. Muller-Goymann CC, Hamann HJ. Pharmacosomes: Multilamellar vesicles consisting of pure drug. Eur J Pharm Biopharm, 1991; 37: 113–117.
17. A. Singh and R. Jain, “Targeted Vesicular Constructs for cryoprotection and treatment of H. Pylori infections,” US Patent 6576, 2003, 625.
18. Kolar kusuma, D. Priyanka, J. Sundaraseelan. Formulation and evaluation of pharmacosomal gel loaded with NSAID. WJPMR2018; 4 (7): 81-88.
19. Semalty A, Semalty M, Rawat BS, Singh D, Rawat MSM. Development and characterization of aspirin- phospholipid complex for improved drug delivery. IJPS 2010; 2(2): 940-947.
20. Semalty A, Semalty M, Rawat B S, Singh D, Rawat MSM. Development and evaluation of pharmacosomes of aceclofenac. IJPS 2010;72: 576-81.
21. Kamalesh M, Baviskar D, Wagh K, Baviskar K. Formulation and evaluation of pharmacosomes of Ketoprofen. Indo Am J Pharm Res. 2014; 4(3): 1363-1368.
22. Raikhman L M, Ivanov V E, Moshkovskii Y S. Development of Ibuprofen pharmacosomes for enhancing the bioavailability. Drug Dev Indian Pharm. 2002; 28(5): 473-482.
23. Letha S, Shammika P, Viswanand V. Formulation and evaluation of etodolac pharmacosomes: A novel approach towards rheumatoid arthritis. IJPT 2017; 9(2): 29665-29680.
24. Semalty A, Semalty M, Rawat BS, Singh D, Rawat MSM. Development and physicochemical evaluation of pharmacosomes of diclofenac. IJPS 2010; 59: 335-344.
25. Raval, Madhabhai M. Patel Techniques to Improve Bioavailability of Poorly Water Soluble Drugs – A review Amit J. Research J. Pharma. Dosage Forms and Tech. 2011; 3(5): 182-192.
26. Kanti Sahu, Rishita Pathak, Naveen Agrawal, Pinkesh Banjare, Harish Sharma, Gyanesh Sahu, Review of the Novel Drug Delivery System used in the Treatment of CancerRes. J. Pharma. Dosage Forms and Tech.2019; 11(3): 199-205.
27. Selvakumar Kalimuthu and AV Yadav, Nanobased Drug Delivery System: A ReviewResearch J. Pharm. and Tech. 2(1): Jan.-Mar. 2009; Page 21-27.
28. Shiva Kumar Yellanki, Jeet Singh, Naveen Kumar Nerella, Sambit Kumar Deb and Sharada Goranti, Nanotechnology for Poorly Soluble Drugs, Research J. Pharm. and Tech.3 (3): July-Sept. 2010; Page 688-693.
29. Sunder Raj Manvi, V. R. M. Gupta, K. Srikanth, N. Devanna, Formulation and Evaluation of Candesartan Niosomal Suspension, Research J. Pharm. and Tech. 5(12): Dec. 2012; Page 1570-1572.