Volume No. :   9

Issue No. :  2

Year :  2019

ISSN Print :  2231-5683

ISSN Online :  2231-5691


Registration

Allready Registrered
Click to Login

A Review- Nanosuspension Technology in Drug Delivery System



Address:   Sarika V. Khandbahale
R. G. Sapkal Institute of Pharmacy, Anjaneri, Nashik
*Corresponding Author
DOI No: 10.5958/2231-5691.2019.00021.2

ABSTRACT:
Solubility is the crucial factor for drug effectiveness, independence of the route of administration. Large proportions of newly discovered drugs are water insoluble, and therefore poorly bioavailable contributing to deserted development effort. These so-called 'Brickellia' candidates can now be delivered by formulating them into Nanosuspension. Nanosuspension technology solved the problem of drugs which are poorly aqueous soluble and less bioavailability. Stability and bioavailability of the drugs can be improved by the Nanosuspension technology. Preparation of Nanosuspension is simple and applicable to all drugs which are aqueous insoluble. Nanosuspensions are prepared by using wet mill, high pressure homogenizer, emulsion-solvent evaporation, melt emulsification method and super critical fluid techniques. Nanosuspension can be prepared by using stabilizers, organic solvents and other additives such as buffers, salts, polyols, osmogent and cryoprotectant. Nanosuspensions can be delivered by oral, parenteral, pulmonary and ocular routes. Nanosuspensions can also be used for targeted drug delivery when incorporated in the ocular inserts and mucoadhesive hydrogels.
KEYWORDS:
Dissolution, Nanosuspension, Saturation solubility, Solubility enhancement, Surfactant.
Cite:
Sarika V. Khandbahale. A Review- Nanosuspension Technology in Drug Delivery System. Asian J. Pharm. Res. 2019; 9(2): 130-138.
[View HTML]     



Visitor's No. :   181367