Author(s):
Umesh A. Bahiram, Someshwar G. Aghav
Email(s):
umeshbahiram36@gmail.com
DOI:
10.52711/2231-5691.2026.00047 
Address:
Umesh A. Bahiram*, Someshwar G. Aghav
Department of Pharmaceutics, DCOP, Satana, Nashik, SPPU, Pune, Maharashtra, India - 422003.
*Corresponding Author
Published In:
Volume - 16,
Issue - 3,
Year - 2026
ABSTRACT:
An innovative development in transdermal medication administration, microneedles provide a painless and minimally invasive substitute for conventional techniques. The several kinds of microneedles, their manufacturing processes, and their uses in drug administration are examined in this review article. Solid, coated, dissolving, hollow, and hydrogel-forming microneedles are the main varieties; each has special qualities and benefits. The main function of solid microneedles is to improve the permeability of the skin for later medication delivery by forming microchannels in it. In contrast, coated microneedles are pre-coated with a medication solution that dissolves when the needle is inserted into the skin, enabling instant drug release. Biodegradable polymers used to make dissolving microneedles disintegrate and release the medication gradually, offering a controlled release method. With the hollow bore of hollow microneedles, liquid medications may be injected straight into the skin, providing exact control over dose. When hydrogel-forming microneedles are inserted into the skin, they expand, allowing for prolonged, continuous medication delivery. Microneedles are made using a variety of methods, such as 3D printing, micromolding, and lithography. These techniques provide for exact control over the microneedles' dimensions, morphology, and composition, guaranteeing peak performance for certain uses. The selection of materials, including metals, polymers, and ceramics, is also essential in defining the microneedles' mechanical strength, biocompatibility, and rate of disintegration. Compared to conventional drug delivery techniques, microneedles provide a number of benefits. They improve compliance and lessen patient discomfort since they are painless and minimally intrusive. Microneedles' high medication bioavailability guarantees effective therapeutic agent delivery straight into the circulation, avoiding the liver's first-pass processing. This lowers the necessary dosage while increasing the medications' efficacy. Furthermore, microneedles facilitate self-administration, enabling patients to take charge of their own care.
Cite this article:
Umesh A. Bahiram, Someshwar G. Aghav. Microneedles for Transdermal Drug Delivery: A Painless Approach to Drug Administration. Asian Journal of Pharmaceutical Research. 2026; 16(3):320-4. doi: 10.52711/2231-5691.2026.00047
Cite(Electronic):
Umesh A. Bahiram, Someshwar G. Aghav. Microneedles for Transdermal Drug Delivery: A Painless Approach to Drug Administration. Asian Journal of Pharmaceutical Research. 2026; 16(3):320-4. doi: 10.52711/2231-5691.2026.00047 Available on: https://asianjpr.com/AbstractView.aspx?PID=2026-16-3-15