Author(s): Rohan R. Vakhariya, S. M. Kumbhar, R. B. lade, P. S. Salunkhe, R. H. Ubale

Email(s): rohanwakhariya@gmail.com

DOI: 10.5958/2231-5691.2020.00002.7   

Address: Mr. Rohan R. Vakhariya*, S. M. Kumbhar, R. B. lade, P. S. Salunkhe, R. H. Ubale
Rajarambapu College of Pharmacy, Kasegaon, Tal.- Walwa, Dist.- Sangli, Maharashtra
*Corresponding Author

Published In:   Volume - 10,      Issue - 1,     Year - 2020


ABSTRACT:
Solubility enhancement of poorly aqueous soluble drugs is an important aspect of formulation development. Dissolution of drug is rate determining step for oral absorption of poorly watersoluble drugs, which consequently affect the in-vivo absorption of drug. Ramipril is a poorly watersoluble drug and it also has poor bioavailability. Therefore, many strategies have been worked out to develop its aqueous solubility as well as its release rate from various solid dosage forms. In the present study, the solid dispersion technique was evaluated for enhancement of solubility and dissolution rate. In present study solid dispersion was prepared by using two different polymers i.e. ß-cyclodextrin, Hydroxypropyl cellulose and there combination also with different drug-carrier ratios was evaluated for the enhancement of solubility and dissolution rate as well as flowability, compressibility of Ramipril. The solid dispersions were characterized by UV Spectroscopy, In Vitro Drug Release, etc.


Cite this article:
Rohan R. Vakhariya, S. M. Kumbhar, R. B. lade, P. S. Salunkhe, R. H. Ubale. Dissolution Rate Enhancement of Ramipril by Solid Dispersion Technique. Asian J. Pharm. Res. 2020; 10(1):08-12. doi: 10.5958/2231-5691.2020.00002.7


Recomonded Articles:

Author(s): Hiral A. Makadia, Ami Y. Bhatt, Ramesh B. Parmar, Ms. Jalpa S. Paun, H.M. Tank

DOI:         Access: Open Access Read More

Author(s): Mercy Mathew, Ravikumar, Simila Madathil, Anju Govind, Narayana Swamy VB

DOI: 10.5958/2231-5691.2016.00015.0         Access: Open Access Read More

Author(s): Rutuja S. Shah, Rutuja R. Shah, Manoj M. Nitalikar, Chandrakant S. Magdum

DOI: 10.5958/2231-5691.2017.00028.4         Access: Open Access Read More

Author(s): Injamamul Haque, Ravikumar, Narayanaswamy VB, Mohibul Hoque

DOI: 10.5958/2231-5691.2016.00023.X         Access: Open Access Read More

Author(s): Bijay Kumar Sahoo, Sidheswar Prasad Pattajoshi, Sandhyarani Pattajoshi

DOI: 10.5958/2231-5691.2018.00011.4         Access: Open Access Read More

Author(s): Vidya Dange , Shubhangi Shid, C.S. Magdum ,S.K. Mohite, M.M. Nitalikar

DOI: 10.5958/2231-5691.2015.00032.5         Access: Open Access Read More

Author(s): B.A. Bhairav, J.K. Bachhav, R.B. Saudagar

DOI: 10.5958/2231-5691.2016.00025.3         Access: Open Access Read More

Author(s): Rutuja S. Shah, Rutuja R. Shah, Manoj M. Nitalikar, Chandrakant S. Magdum

DOI: 10.5958/2231-5691.2017.00024.7         Access: Open Access Read More

Author(s): Sravani Koralla, Sathish Kumar Konidala, K Govinda Rao, Sheik Mobina Begum

DOI:         Access: Open Access Read More

Author(s): Indrajeet S. Patil, Omkar A. Patil, Girish Chandra R. Mandake, Manoj M. Nitalikar

DOI: 10.5958/2231-5691.2018.00035.7         Access: Closed Access Read More

Author(s): P. K. Wagh, S. P. Ahirrao, S. J. Kshirsagar

DOI: 10.5958/2231-5691.2019.00013.3         Access: Closed Access Read More

Author(s): Kaustubh V. Gavali, Manohar D. Kengar, Kiran V. Chavan, Vaishnavi P. Anekar, Naziya I. Khan

DOI: 10.5958/2231-5691.2019.00020.0         Access: Closed Access Read More

Author(s): Ashok Thulluru, Nawaz Mahammed, C. Madhavi, K. Nandini, S. Sirisha, D. Spandana

DOI: 10.5958/2231-5691.2019.00016.9         Access: Closed Access Read More

Author(s): Mitul R. Vasanani, Nisha Patel, Divyakant Patel , Rajesh KS, Lalit Lata Jha

DOI:         Access: Open Access Read More

Author(s): Sarika V. Khandbahale

DOI: 10.5958/2231-5691.2019.00021.2         Access: Closed Access Read More

Author(s): Sugiyartono, Tutiek Purwanti, Isnaeni, Dhenok Reso Fenda Asega

DOI:         Access: Open Access Read More

Author(s): Sarfaraz Md., Prasad Y., Reddy S.R, Doddayya H. , Udupi R.H.

DOI:         Access: Open Access Read More

Author(s): Snehal B. Kulkarni, M. M. Bari,S. D. Barhate, Ashutosh Tripath

DOI: 10.5958/2231-5691.2019.00003.0         Access: Closed Access Read More

Author(s): K. Vijaya Sri, R. Harish Kumar Reddy , R. Mahesh

DOI:         Access: Open Access Read More

Author(s): B. Babu Rao, P. Harish, Saikat Das, T. Ashwin Kumar, V. Raman Koundinya

DOI:         Access: Open Access Read More

Asian Journal of Pharmaceutical Research (AJPRes.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. AJPRes. publishes Original Research Articles, Short Communications..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231–5691 


Recent Articles




Tags