Volume No. :   10

Issue No. :  2

Year :  2020

ISSN Print :  2231-5683

ISSN Online :  2231-5691


Registration

Allready Registrered
Click to Login

Comparative study of In-Vivo effects of Glipizide and Metformin HCl on plasma concentration of Aminophylline in healthy rabbits



Address:   Palaksha MN1, Tamizh Mani T1, Manjunatha E2*, G P Senthil Kumar1
1Bharathi College of Pharmacy, Bharathinagara, Mandya-571422.
2Siddaganga College of Pharmacy, Tumkur-572102.
*Corresponding Author
DOI No: 10.5958/2231-5691.2020.00012.X

ABSTRACT:
A drug interaction is the modification of the effects of one drug in the presence of other drug. The interaction can modify the drugs by forming chemical complex, nullify the action, increase the effect, decrease the effect, induce or inhibit the hepatic metabolism and elimination rate of the one drug in presence of other drug. The in-vivo effects of Glipizide and Metformin Hcl on plasma concentration of Aminophylline have been studied in rabbits. In this study, the plasma concentration of Aminophylline was determined by UV spectroscopic method using calibration curve, after oral single administration of Aminophylline alone and with Glipizide and Metformin HCL in rabbits was determined. The results have shown that Aminophylline can enhance both Glipizide and Metformin HCl plasma concentration in rabbits. The data obtained would help us to suggest that Glipizide as well as Metformin HCl may result into compatible combination therapies with Aminophylline an antiasthmatic drug is useful in the treatment of diabetic patients.
KEYWORDS:
Drug-Interaction, Metformin, Aminophylline, Glipizide, UV-Spectrophotometer.
Cite:
Palaksha MN, Tamizh Mani T, Manjunatha E, G P Senthil Kumar. Comparative study of In-Vivo effects of Glipizide and Metformin HCl on plasma concentration of Aminophylline in healthy rabbits. Asian J. Pharm. Res. 2020; 10(2):62-66.
[View HTML]     



Visitor's No. :   226759