Asian Journal of Pharmaceutical Research

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2231-5691 (Online)
2231-5683 (Print)


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Synthesis, Characterization, Anti Microbial, Analgesic activities of 3-(3-Chlorophenyl)-5-Phenyl-4,5-Dihydro-1,2-Oxazole Derivatives

Author(s): V Jhansipriya Marabathuni, K. Mariyamma, K. Sravani, S. Ramaiah, P. Ravindra, R. Srihari

Email(s): Email ID Not Available

DOI: 10.5958/2231-5691.2017.00026.0   

Address: V Jhansipriya Marabathuni *, K. Mariyamma, K. Sravani, S. Ramaiah, P. Ravindra, R. Srihari
Department of Pharmaceutics, Bellamkonda Institute of Technology and Sciences, Podili
*Corresponding Author

Published In:   Volume - 7,      Issue - 3,     Year - 2017

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ABSTRACT:
Novel Isoxazoles are prepared by treating chalcone derivatives from 3- Chloro acetophenone with hydroxyl amine hydro chloride, small amount of sodium acetate and ethanol. The chalcone were prepared by using the 3-chloro Acetophenone with aromatic aldehydes in presence of NaOH followed by Clasein-Schmidt condensation reaction. All the synthesised compounds were characterized by using the IR, H1 NMR spectroscopy. The biological evolution like anti bacterial and analgesic activity was performed for test compounds to identify the activity. Here the disc diffusion method performed to identify the anti bacterial activity by measuring of zone of inhibition in mm compared with standard streptomycin and analgesic activity by performing the tail immersion method measuring the percentage of inhibition compare with standard Paracetamol at dose of 100 mg/kg.


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Cite this article:
V Jhansipriya Marabathuni, K. Mariyamma, K. Sravani, S. Ramaiah, P. Ravindra, R. Srihari. Synthesis, Characterization, Anti Microbial, Analgesic activities of 3-(3-Chlorophenyl)-5-Phenyl-4,5-Dihydro-1,2-Oxazole Derivatives. Asian J. Pharm. Res. 2017; 7(3):171-174. doi: 10.5958/2231-5691.2017.00026.0


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Asian Journal of Pharmaceutical Research (AJPRes.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. AJPRes. publishes Original Research Articles, Short Communications..... Read more >>>

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DOI: 10.5958/2231–5691 

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Asian Journal of Pharmaceutical Research (AJPRes.) (ISSN: Print-2231–5683, Online-2231–5691) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. AJPRes. publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences .

The journal is published quarterly every year in last week of March, June, September and December from Raipur, India.    
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