Author(s): Ganesh Akula, Rangu Nirmala, CH. Shanthipriya, S. Rohini Reddy, A. Jaswanth

Email(s): akulaganesh@gmail.com

DOI: 10.5958/2231-5691.2017.00010.7   

Address: Ganesh Akula1*, Rangu Nirmala2, CH. Shanthipriya2, S. Rohini Reddy2, Dr. A. Jaswanth2
1Department of Pharmaceutical Chemistry, Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel (M), Siddipet (D), Telangana-502312
2Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel (M), Siddipet (D), Telangana-502312
*Corresponding Author

Published In:   Volume - 7,      Issue - 2,     Year - 2017


ABSTRACT:
Literature survey reveals that in recent years several Quinazolinone derivatives have been synthesized and reported to possess varied biological and pharmacological properties. They are found to be useful as antibacterial, analgesic, anti-inflammatory, antifungal, anticonvulsant and anticancer agents. A new series of 3-[(di alkyl amino) methyl]-2-substituted-4(3H)-Quinazolinones were synthesized by the reaction of a mixture of 2-substituted-4(3H)-Quinazolinone, formaldehyde and dialkyl or diaryl amine by mannich reaction. The chemical structures of the synthesized compounds were confirmed by IR, mass spectral and C, H, N analysis techniques. The synthesized compounds were screened for anti-inflammatory activity by the carrageenan induced rat hind paw edema method. The synthesized compounds were significantly showed their anti-inflammatory activity that of standard.


Cite this article:
Ganesh Akula, Rangu Nirmala, CH. Shanthipriya, S. Rohini Reddy, A. Jaswanth. Synthesis of novel 3-[(dialkyl/aryl amino) methyl]-2-substituted-4(3H)-Quinazolinones and evaluation of their Anti-inflammatory activity. Asian J. Pharm. Res. 2017; 7(2): 60-62. doi: 10.5958/2231-5691.2017.00010.7


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DOI: 10.5958/2231–5691 


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