Sahil Hasan, Saloni Bhandari, Anshu Sharma, Poonam Garg
Sahil Hasan*, Saloni Bhandari, Anshu Sharma, Poonam Garg
Bhupal Noble’s College of Pharmacy, Udaipur (313001) Rajasthan, India.
Volume - 11,
Issue - 4,
Year - 2021
Emulgel systems are currently attention to the pharmaceutical sectors because of their substantial potential to act as drug delivery vehicle by incorporating a broad range of drug molecules and higher stability compared to the other dosage form like cream, lotion, gel, etc. Emulsions are either available in an oil in water or water in oil type. These are prepared by the incorporation of the emulsion into the gel with constant stirring at a moderate speed. Incorporation of emulsion into a gel makes it a dual control release system, thereby, increasing its stability. It has better drug release if we compare to other topical drug delivery system. It is non greasy because of the presence of gel phase which enhances patient compliance. Gels has a major limitation for the delivery of hydrophobic drugs, so to overcome this limitation an emulsion based approach is being used so that even a hydrophobic therapeutic drug can enjoy the unique properties of gels. In recent years, these have also been a great interest in the use of novel polymers. These emulgels are having major advantages on vesicular drug delivery systems as well as on conventional systems in various aspects. Various permeation enhancers can enhance the effect; due to this emulgels can be used as better topical drug delivery systems over current drug delivery systems. The emulsion can be use for analgesics and antifungal drugs.
Cite this article:
Sahil Hasan, Saloni Bhandari, Anshu Sharma, Poonam Garg. Emulgel: A Review. Asian Journal of Pharmaceutical Research. 2021; 11(4):263-8. doi: 10.52711/2231-5691.2021.00047
Sahil Hasan, Saloni Bhandari, Anshu Sharma, Poonam Garg. Emulgel: A Review. Asian Journal of Pharmaceutical Research. 2021; 11(4):263-8. doi: 10.52711/2231-5691.2021.00047 Available on: https://asianjpr.com/AbstractView.aspx?PID=2021-11-4-9
1. Stan-Posthumd J, Vink J, le Cessie S, et al. Topical Tretinoin Under Occlusion on a Typical Navei. Melanoma Res. 1988; 548: 539-48.
2. Zignani M, Tabatabay C, Gurny R. Topical Semi-Solid Drug Delivery: Kinetics and Tolerance of Ophthalmic Hydrogels. Advanced Drug Delivery Reviews. 1995; 16(1): 51-60.
3. Sharma S. Topical Preparations are used for the Localized Effects at the Site of their Application by Virtue of Drug Penetration into the Underlying Layers of Skin or Mucous Membranes. Pharmaceutical Reviews. 2008; 6(1): 26-39.
4. Ellaithy HM, El-Shaboury KM. The Development of Cutina Lipogels and Gel Microemulsion for Topical Administration of Fluconazole. AAPS Pharmscitech. 2002; 3(4): 77-85.
5. Meenakshi D. Emulgel: A Novel Approach to Topical Drug Delivery. International Journal of Pharma and Bio Sciences, Int J Pharm Bio Sci Jan. 2013; 4(1): 847-56.
6. Bhatt P, Gnanarajan G. Emulgels: A Novel Formulation Approach for Topical Delivery of Hydrophobic Drugs. International Research Journal of Pharmacy. 2013; 4(2): 12-6.
7. Kumar D, Singh J, Antil M, Kumar V. Emulgel-Novel Topical Drug Delivery System- A Comprehensive Review. International Journal of Pharmaceutical Sciences and Research. 2016; 7(12): 4733.
8. Haneef KPM, Easo S, Hafsa PV, et al. Emulgel: An Advanced Review. Journal of Pharmaceutical Science and Research, 2013; 5(12): 254-258.
9. Rana N, Singh V, Mohd. Ali M. Formulation and Characterization of Ginger oil loaded Polyherbal Emulgels having extracts of Nardostachys jatamansi, Andrographis paniculata and Celaestrus paniculatus. Research J. Pharm. and Tech 2020; 13(9): 4077-4083. DOI: 10.5958/0974-360X.2020.00720.9.
10. Kute S, Saudagar R. Emulsified Gel: A Novel approach for Delivery of Hydrophobic Drugs: An Overview. Journal of Advanced Pharmacy Education and Research Oct-Dec. 2013; 3(4).
11. Joshi B, Singh G, Rana AC, et al. Emulgel: A Comprehensive Review on the Recent Advances in Topical Drug Delivery. Int Res J Pharm. 2011; 2(11): 66-70.
12. Singla V, Saini S, Joshi B, Rana AC. Emulgel: A New Platform for Topical Drug Delivery. International Journal of Pharma and Bio Sciences. 2012; 3(1): 485-98.
13. Hardenia A, Jayronia S, Jain S. Emulgel: An emergent tool in topical drug delivery. International journal of pharmaceutical sciences and research. 2014; 5(5): 1653.
14. Pathan IB, Setty CM. Chemical Penetration Enhancers for Transdermal Drug Delivery Systems. Tropical Journal of Pharmaceutical Research. 2009; 8(2).
15. Vats S, Saxena C, Easwari TS, Shukla VK. Emulsion Based Gel Technique: Novel Approach for Enhancing Topical Drug Delivery of Hydrophobic Drugs. IJPRS. 2014; 3: 649.
16. Khullar R, Saini S, Seth N, Rana AC. Emulgels: A Surrogate Approach for Topically Used Hydrophobic Drugs. Int J Pharm Bio Sci. 2011; 1(3): 117-28.
17. Jain NK. Progress in Controlled and Novel Drug Delivery Systems. New Delhi. CBS Publishers and Distributors; 2004.
18. Eswaraiah S, Swetha K, Lohita M. Emulgel: Review on Novel Approach to Topical Drug Delivery. Asian J. Pharm. Res. 2014; 4(1): 4-11
19. Shingade GM. Review on: Recent Trend on Transdermal Drug Delivery System. Journal of drug delivery and therapeutics. 2012; 2(1).
20. Lachman L, Lieberman HA, Kanig JL. The Theory and Practice of Industrial Pharmacy. Philadelphia: Lea and Febiger; 1976.
21. Vyas SP, Khar RK. Controlled Drug Delivery Concepts and Advances. Vallabh Prakashan. 2002; 1: 411- 447.
22. Bonacucina G, Cespi M, Palmieri GF. Characterization and Stability of Emulsion Gels Based On Acrylamide/Sodium Acryloyldimethyl Taurate Copolymer. AAPS Pharmscitech. 2009; (2): 368-75.
23. Benson HA. Transdermal Drug Delivery: Penetration Enhancement Techniques. Current Drug Delivery. 2005; 2(1): 23-33.
24. Rutter N. Drug Absorption through the Skin: A Mixed Blessing. Archives of Disease in Childhood. 1987; 62(3): 220.
25. Zhang XL, Zhao R, Qian W. Preparation of an Emulgel for Treatment of Aphthous Ulcer on the Basis of Carbomers. Chin Pharm J. 1995; 30: 417-8.
26. Yadav SK, Mishra MK, Tiwari AN, et al. Emulgel: A New Approach for Enhanced Topical Drug Delivery. Int J Curr Pharm Res. 2016; 9(1): 15-9.
27. Broadhead J, Gibson M. Parenteral Dosage Forms. Pharmaceutical Preformulation and Formulation: A Practical Guide from Candidate Drug Selection to Commercial Dosage Form. 2009: 331-54.
28. Mortazavi SA, Abou Fazeli R. An Investigation into the Effect of Various Penetration Enhancers on Percutaneous Absorption of Piroxicam.
29. Kumar L, Verma R. In Vitro Evaluation of Topical Gel Prepared Using Natural Polymer. International Journal of Drug Delivery. 2010; 2(1).
30. Jacob SW, Francone CA, Lossow WJ. Structure and Function in Man. Unknown Journal. 1978 Jan 1: I-XVI+.
31. Redkar MR, Hasabe PS, Jadhav ST. Review on Optimization base Emulgel Formulation. Asian J. Pharm. Tech. 2019; 9(3):228-237. DOI: 10.5958/2231-5713.2019.00038.2.
32. Mohamed MI. Optimization of chlorphenesin emulgel formulation. The AAPS journal. 2004; 6(3): 81-7.
33. Sawant AA, Mohite SK. Formulation and Evaluation of Itraconazole Emulgel for Topical Drug Delivery. Asian J. Pharm. Tech. 2015; 5(2): 91-96.
34. Ashara K, Soniwala M, Shah K. Emulgel: A Novel Drug Delivery System. Journal of Pakistan Association of Dermatology. 2017; 26(3): 244-9.
35. Ashara KC, Paun JS, Soniwala MM, et al. Micro-Emulsion Based Emulgel: A Novel Topical Drug Delivery System. Asian Pac J Trop Dis Journal 2014; 4: 27-32.
36. Khunt DM, Mishra AD, Shah DR. Formulation Design and Development of Piroxicam Emulgel. Int J PharmTech Res 2012; 4: 1332-44.
37. Manne N, Yadav HK, Kumar SH, et al. Design And Evaluation of a Lyophilized Liposomal Gel of an Antiviral Drug for Intravaginal Delivery. Journal of Applied Polymer Science. 2014 Jan; 131(2).
38. Masmoudi H, Piccerelle P, Le Dréau Y, Kister J. A Rheological Method to Evaluate the Physical Stability of Highly Viscous Pharmaceutical Oil-In-Water Emulsions. Pharmaceutical Research. 2006; 23(8): 1937-47.
39. Praveen C, Amit A, Prashant M, et al. Development and In Vitro Evaluation of Thermo Reversible Nasal Gel Formulations of Rizatriptan Benzoate. Indian Journal of Pharmaceutical Education and Research. 2009; 43(1): 55-62.
40. Harshitha V, Venkata Swamy M, Prasanna Kumar DK. Nanoemulgel: A Process Promising in Drug Delivery System. Res. J. Pharma. Dosage Forms and Tech. 2020; 12(2): 125-130. DOI: 10.5958/0975-4377.2020.00022.1.