HPLC Determination of Two Cephalosporines with one Macrolide in Bulk and Dosage Forms

Sobhy M. El-Adl; Mohamed El. Hossinny El. Sadek; Marwa Hamdy Hassan

Asian Journal of Pharmaceutical Research

ISSN

2231-5691 (Online)
2231-5683 (Print)

Submit Article

HPLC Determination of Two Cephalosporines with one Macrolide in Bulk and Dosage Forms

Author(s): Sobhy M. El-Adl, Mohamed El. Hossinny El. Sadek, Marwa Hamdy Hassan

Email(s): elmohands_eg@yahoo.com

DOI: Not Available

Address: Sobhy M. El-Adl*, Mohamed El. Hossinny El. Sadek, Marwa Hamdy Hassan
Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazige University, Zagazig, Egypt.
*Corresponding Author

Published In: Volume - 4, Issue - 4, Year - 2014

View HTML

View PDF

ABSTRACT:
An isocratic HPLC method had been developed for rapid simultaneous separation and determination of two cephalosporins with one macrolide including Claritromycin, Cefixime and Cefoperazone in pure form or in pharmaceutical formulations within less than 5 minutes. Separation was carried out on a Hypersil gold C18 (10um, 100x4.6mm) column. Effect of pH and composition of mobile phase in addition to flow rates was studied. Beer’s law was obeyed in the range of 1-50 µg/ml for Clarithromycin and Cefixime or 2-50 ug\ml for Cefoperazone. The method was applied for the determination of drugs in both bulk and pharmaceutical forms and were validated when obtained results were compared with reference methods.

Keywords:

Cite this article:
Sobhy M. El-Adl, Mohamed El. Hossinny El. Sadek, Marwa Hamdy Hassan. HPLC Determination of Two Cephalosporines with one Macrolide in Bulk and Dosage Forms. Asian J. Pharm. Res. 4(4): Oct.-Dec.2014; Page 180-185.

Cite(Electronic):
Sobhy M. El-Adl, Mohamed El. Hossinny El. Sadek, Marwa Hamdy Hassan. HPLC Determination of Two Cephalosporines with one Macrolide in Bulk and Dosage Forms. Asian J. Pharm. Res. 4(4): Oct.-Dec.2014; Page 180-185. Available on: https://asianjpr.com/AbstractView.aspx?PID=2014-4-4-3

Recomonded Articles:

Pharmaceutical Importance and Significance of Limit Tests

Author(s): Habeeb Ahmed, Mohammed Ehtesham, Nuha Rasheed , Abdul Saleem Mohammad

DOI: 10.5958/2231-5691.2017.00006.5 Access: Open Access Read More

Formulation of Povidone Iodine vaginal suppository containing Lacto bacillus spores.

Author(s): S.C. Shivhare, U.D.Shivhare, Preeti Srivastav, K.G. Malviya

DOI: Access: Open Access Read More

Review on Solubility Enhancement Techniques

Author(s): B.A. Bhairav, J.K. Bachhav, R.B. Saudagar

DOI: 10.5958/2231-5691.2016.00025.3 Access: Open Access Read More

Analytical Method Development in Pharmaceutical Research: Steps involved in HPLC Method Development

Author(s): Hamid Khan

DOI: 10.5958/2231-5691.2017.00031.4 Access: Open Access Read More

Generic Vs. Brand Medicines: An Overview

Author(s): Nikita R. Nikam, Rohan R. Vakhariya, Dr. C. S. Magdum

DOI: 10.5958/2231-5691.2019.00018.2 Access: Open Access Read More

Design, Development and Evaluation of Enteric Coated Tablets of Glimepiride

Author(s): Rutuja S. Shah, Rutuja R. Shah, Manoj M. Nitalikar, Chandrakant S. Magdum

DOI: 10.5958/2231-5691.2017.00024.7 Access: Open Access Read More

A Review on Natural Binders used in Pharmacy

Author(s): Subhashis Debnath, C. Navya Yadav, N. Nowjiya, M. Prabhavathi, A. SaiKumar, P. Sai Krishna, M. Niranjan Babu

DOI: 10.5958/2231-5691.2019.00009.1 Access: Open Access Read More

Significance of Pharmaceutical Excipients on Solid Dosage form Development: A Brief Review

Author(s): Sandesh Narayan Somnache, Ajeet Madhukar Godbole, Pankaj Sadashiv Gajare, Sapna Kashyap

DOI: 10.5958/2231-5691.2016.00028.9 Access: Open Access Read More

Introduction to Pharmacovigilance and Monitoring

Author(s): Manohar D. Kengar, Kiran K. Patole, Akshay K. Ade, Sumesh M. Kumbhar, Chetan D. Patil, Ashutosh R. Ganjave

DOI: 10.5958/2231-5691.2019.00019.4 Access: Open Access Read More

A Brief Review on Genotoxic impurities in Pharmaceuticals

Author(s): Ashok B. Patel, Ashish H. Asnani, Amitkumar J. Vyas, Nilesh K. Patel, Ajay I. Patel, Arvind N. Lumbhani

DOI: 10.52711/2231-5691.2021.00034 Access: Open Access Read More

A Review on New Herbal Remedies for treatment of Mouth Ulcer

Author(s): Rina G. Maskare, Ayush P. Agrawal, Mayuri S. Pal, Jidnyasa R. Yerne, Megham Chaudhri, Anup R. Bawankar, Gaytri B. Sonkusre

DOI: 10.52711/2231-5691.2022.00025 Access: Open Access Read More

Reverse Logistic Practices on Household Medical Disposal in India and its Impacts on Environment

Author(s): Manoj Kumar. T, Saravanan. S

DOI: 10.5958/2231-5691.2016.00016.2 Access: Open Access Read More

Emulgel: A Review

Author(s): Sahil Hasan, Saloni Bhandari, Anshu Sharma, Poonam Garg

DOI: 10.52711/2231-5691.2021.00047 Access: Open Access Read More

Exploration and Phytochemical Estimation of Murraya koenigii Leaves for Pharmaceutical Applications

Author(s): Radheshyam Sharma, Umesh Kumar

DOI: 10.5958/2231-5691.2019.00025.X Access: Open Access Read More

Development and Validation of UV Spectrophotometric Method for Estimation of Lurasidone in Bulk and Pharmaceutical Formulations

Author(s): K. Vijaya Sri, S. Sravani, M. Shiva Kumar

DOI: 10.5958/2231-5691.2015.00015.5 Access: Open Access Read More

Ethno Pharmacological Uses of Artocarpus altilis– A Review

Author(s): Vidya Raju*, Jasmine Joy Bell, Merlin. N. J, Shaiju S Dharan

DOI: 10.5958/2231-5691.2017.00037.5 Access: Open Access Read More

Dendrimer: A Review

Author(s): Sheetal B. Gondkar, Shalaka P. Rasal, Ravindra B. Saudagar

DOI: 10.5958/2231-5691.2016.00027.7 Access: Open Access Read More

Simultaneous UV Spectrophotometric Methods for Estimation of Cefixime Trihydrate and Ofloxacin in Bulk and Tablet Dosage Form

Author(s): Audumbar Mali, Santosh Jadhav, Rahul Gorad, Aamer Quazi, Ritesh Bath, Manojkumar Patil, Ashpak Tamboli

DOI: 10.5958/2231-5691.2016.00017.4 Access: Open Access Read More

Mouth Dissolving Tablet: A Novel Drug Delivery System

Author(s): Davesh S. Jire, Nitin S. Gosavi, Roshan B. Badhe, Dipak H. Jagdale

DOI: 10.52711/2231-5691.2021.00033 Access: Open Access Read More

A Review- Ceftriaxone for Life

Author(s): Mohd. Yaqub Khan, Maryada Roy, Raj Kumar Rawal, Umesh Kumar Bansal

DOI: 10.5958/2231-5691.2017.00007.7 Access: Open Access Read More

Asian Journal of Pharmaceutical Research (AJPRes.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. AJPRes. publishes Original Research Articles, Short Communications..... Read more >>>

RNI: Not Available
DOI: 10.5958/2231–5691