Author(s):
Snehlata Kurme, Nupur Kate, Pallavi Lute, Ishwar Gorle, Mayuri Bedre, Sharayu Paygan
Email(s):
snehlatakurme730@gmail.com
DOI:
10.52711/2231-5691.2025.00023 
Address:
Snehlata Kurme1*, Nupur Kate1, Pallavi Lute1, Ishwar Gorle1, Mayuri Bedre2, Sharayu Paygan3
1Department of Pharmacy, Dr. Rajendra Gode Institute of Pharmacy, Amravati – 444602.
2Department of Pharmaceutics, Prerna Institute of Pharmacy, Parbhani – 431401.
3Department of Pharmaceutics, Pataldhamal Wadhwani College of Pharmacy, Yavatmal – 445001.
*Corresponding Author
Published In:
Volume - 15,
Issue - 2,
Year - 2025
ABSTRACT:
The current study's goal was to create and assess a sunscreen that contained Allium canadense microspheres. The solvent evaporation technique was employed to produce the microspheres. Dichloromethane was used as the solvent, while ethylene was utilized as a polymer for the drug's coating. In different ratios, the pure medication and the polymers got along quite well. The produced ratios showed a percent of drug entrapment of 58.07±1.02%, the in-vitro research showed a percent of drug release of 99.08%, and the ex-vivo study showed a percent of drug release of 98.47% in 12hours. The produced cream formulation was proven to be safe for usage with good sun protection activity based on the histopathological examination. According to the in-vitro SPF research and sun screen efficacy, the produced formulation had an SPF value of 3.909257 and a maximum absorbance of 2.432nm. According to the cream's photostability research, batch A5 can offer superior UV protection with a stable sunscreen product, whereas the prepared cream was stable and the unstable product began to deteriorate as soon as it was exposed to the sun. The formulation exhibits a zero order drug release with a Korsmeyer-Peppas model mechanism followed by super case II transport, according to the kinetics investigation. When the product was put through the stability study's testing, it was discovered that the modifications were negligible. The prepared microspheres have a better stability and an excellent sun protection activity. They are also safe for skin.
Cite this article:
Snehlata Kurme, Nupur Kate, Pallavi Lute, Ishwar Gorle, Mayuri Bedre, Sharayu Paygan. Formulation and Assessment of Sunscreen Embedded with Microspheres Loaded with Allium canadense Extract. Asian Journal of Pharmaceutical Research. 2025; 15(2):141-8. doi: 10.52711/2231-5691.2025.00023
Cite(Electronic):
Snehlata Kurme, Nupur Kate, Pallavi Lute, Ishwar Gorle, Mayuri Bedre, Sharayu Paygan. Formulation and Assessment of Sunscreen Embedded with Microspheres Loaded with Allium canadense Extract. Asian Journal of Pharmaceutical Research. 2025; 15(2):141-8. doi: 10.52711/2231-5691.2025.00023 Available on: https://asianjpr.com/AbstractView.aspx?PID=2025-15-2-8
REFERENCES:
1. Malviya VR, Pande SD, Bobade NN. Preparation and evaluation of sustained release beads of zolmitriptan hydrochloride. Research Journal of Pharmacy and Technology. 2019; 12(12): 5972-6.
2. Malviya V. Preparation and evaluation of emulsomes as a drug delivery system for bifonazole. Indian Journal of Pharmaceutical Education and Research. 2021 Jan 1; 55(1):86-94.
3. Sari RK, Wahyuningrum M, Rozan SA, Aulia MI, Rafi M, Wientarsih I. In vitro antioxidant and sunscreen activities of gyrinops versteegi leaf extract from different location in Indonesia and phytosome combinations. Research Journal of Pharmacy and Technology. 2022; 15(11): 5106-11.
4. Malviya V, Ladhake V, Gajbiye K, Satao J, Tawar M. Design and characterization of phase transition system of zolmitriptan hydrochloride for nasal drug delivery system. International Journal of Pharmaceutical Sciences and Nanotechnology (IJPSN). 2020 May 31; 13(3): 4942-51.
5. Burange PJ, Tawar MG, Bairagi RA, Malviya VR, Sahu VK, Shewatkar SN, Sawarkar RA, Mamurkar RR. Synthesis of silver nanoparticles by using Aloe vera and Thuja orientalis leaves extract and their biological activity: a comprehensive review. Bulletin of the National Research Centre. 2021 Dec; 45: 1-3.
6. Rathore S, Ram A, Lall D, Agrawal B, Soni P, Naim MJ. Development and evaluation of sunscreen cream containing benzophenone-3 microspheres for enhancing sunscreen activity. Research Journal of Pharmacy and Technology. 2021; 14(11): 6078-84.
7. Malviya V, Thakur Y, Gudadhe SS, Tawar M. Formulation and evaluation of natural gum based fast dissolving tablet of Meclizine hydrochloride by using 3 factorial design 2. Asian Journal of Pharmacy and Pharmacology. 2020; 6(2): 94-100.
8. Yuliani NN, Siswandono S, Erawati T, Sambara J, Korassa Y, Poddar S. Bougenville Flower (Bougainvillae spectabilis Willd) Extract (In Vitro) Activity Test as Sunscreen. Research Journal of Pharmacy and Technology. 2024 Feb 20;17(2):849-54.
9. Malviya VR, Tawar MG. Preparation and evaluation of oral dispersible strips of teneligliptin hydrobromide for treatment of diabetes mellitus. International Journal of Pharmaceutical Sciences and Nanotechnology (IJPSN). 2020 Jan 31; 13(1): 4745-52.
10. Malviya VR, Pande SD. Road CKN. Preparation ad Evaluation of Zolmitriptan Hydrochloride Lozenge. J Pharma Res. 2019;8(8):624-9.
11. Malviya V, Manekar S. Design, development and evaluation of aceclofenac and curcumin agglomerates by Crystallo Co-Agglomeration technique. Research Journal of Pharmacy and Technology. 2021; 14(3): 1535-41.
12. Bhide R, Madasu D, Patil P, Dayal N, Koppaka O, Ather S, Thakur M. Formulation, characterization and in vitro evaluation of proshine MBTMGMIHS herbal sunscreen cream containing flower extract. Research Journal of Pharmacy and Technology. 2023; 16(3): 1309-13.
13. Jubaidah S, Syamsul ES, Wijaya H, Poddar S. Formulation cream from extract of red pidada leaves (Sonneratia caseolaris L.) as a sunscreen and analysis of active compounds with Liquid Chromatography-High Resolution Mass Spectrometry (LC-HRMS) method. Research Journal of Pharmacy and Technology. 2023; 16(2): 781-5.
14. Gangale A, Ambore S, Gavit M, Lokhande S. A Pilot Study on Evaluation of Cucumis sativus L. as a Natural Antisolar agent. Research Journal of Pharmacy and Technology. 2016; 9(3): 212-4.
15. Malviya V, Pande S. Development and Evaluation of Fast dissolving Film of Fluoxetine hydrochloride. Research Journal of Pharmacy and Technology. 2021; 14(10): 5345-50.
16. Malviya V. Design and Characterization of Thermosensitive Mucoadhesive Nasal Gel for Meclizine Hydrochloride: Thermosensitive Nala Gel of Meclizine HCL. International Journal of Pharmaceutical Sciences and Nanotechnology (IJPSN). 2022 Feb 28; 15(1): 5782-93.
17. Ali ZS, Muhammad D, Zrieki A. In vitro Assessment of sun protection factor (SPF) and Antioxidant activity of Viola odorata extracts. Research Journal of Pharmacy and Technology. 2022; 15(2): 655-60.
18. Khelker T, Haque N, Agrawal A. Ultraviolet Protection potential of Curcuma longa L. and Citrus sinensis (L.) Osbeck. Research Journal of Pharmacy and Technology. 2017; 10(12): 4282-4.
19. Malviya V, Burange P, Thakur Y, Tawar M. Enhancement of solubility and dissolution rate of atazanavir sulfate by nanocrystallization. Indian Journal of Pharmaceutical Education and Research. 2021 Jul 1; 55(3): S672-80.
20. Rahmayanti M, Maulidina AT, Putra M. Determination of physical stability spray sunscreen of extract wungu leaf (Graptophyllum pictum (L.) griff) with varied concentrations of glycerine as a humectant. Research Journal of Pharmacy and Technology. 2023; 16(11):5245-9.
21. Malviya V, Tawar M, Burange P, Jodh R. A Brief Review on Resveratrol. Asian Journal of Research in Pharmaceutical Sciences. 2022 May 25; 12(2): 157-62.
22. Malviya V, Arya A, Burange P, Gajbhiye K, Rathod G, Tawar M. To evaluate the cardioprotective effect of hydroalcoholic extract of Matricaria chamomilla linn in isoproterenol induced myocardial infarction in wistar rats. Research Journal of Pharmacy and Technology. 2022;15(9):3887-92.
23. Lokapure SG, Patil SS, Phutane KR, Mohite SK, Magdum CS. In vitro Evaluation of Sun Protection factor and Diffusion study of Hibiscus rosa-sinensis L. flower Extract Gel. Research Journal of Pharmacy and Technology. 2014; 7(6): 643-7.
24. Malviya V, Tawar M, Burange P, Bairagi R. Preparation and Characterization of Gastroreten-tive Sustained Release In-situ Gel of Lafutidine. International Journal of Pharmaceutical Sciences and Nanotechnology (IJPSN). 2022 Dec 12; 15(6): 6216-28.
25. Malviya V. Investigation of in-vitro antidiabetic study, antioxidant activity and anthelminthic property of various extracts of bitter cumin seeds: antidiabetic study, antioxidant activity, and anthelminthic property of bitter cumin seeds. International Journal of Pharmaceutical Sciences and Nanotechnology (IJPSN). 2023 Jul 31; 16(4): 6855-74.
26. Patil A, Masareddy RS, Patil AS, Dwivedi PS. Microsponge gel approach to increase the stability and efficacy of avobenzone as a sun-protective agent. Journal of Pharmaceutical Innovation. 2022 Dec; 17(4): 1347-59.
27. Malviya V, Pande S. Design and Characterization of pH Dependent Phase Transition System of Almotriptan Malate for Nasal Drug Delivery System by Employing Factorial Design. Ind. J. Pharm. Edu. Res. 2024 Jan 1; 58(1): 76-90.
28. Alhakim F, Laham A. In vitro Determination of SPF for Syrian Olive (Olea europaea) leaf extracts. Research Journal of Pharmacy and Technology. 2023; 16(5): 2187-91.
29. Malviya V. Box-Behnken Modeling Served for the Development and Optimization of Nanoparticles Loaded with Perindopril and Erbumine. Asian Journal of Pharmaceutics (AJP). 2023 Sep 15;17(03).
30. Hupel M, Poupart N, Gall EA. Development of a new in vitro method to evaluate the photoprotective sunscreen activity of plant extracts against high UV-B radiation. Talanta. 2011 Oct 30; 86: 362-71.
31. Satao J, Wadaskar P, Bais A, Bhamburkar S, Malviya V. Preparation and Characterization of Benidipine Hydrochloride Microballoons. International Journal of Scientific Development and Research. 2020; 5(6): 176-81.
32. Shenoy PA, Khot SS, Chavan MC, Takawale JV, Singh S. Study of sunscreen activity of aqueous, methanol and acetone extracts of leaves of Pongamia pinnata (L.) pierre, fabaceae. International Journal of Green Pharmacy (IJGP). 2010; 4(4).
33. Bais A, Ghayal S, Rajge R, Malviya V. Preparation and Evaluation of Omeprazole sodium Lozenges by Heating and Congealing Technique. International Journal of Scientific Development and Research. 5(6): 262-8.
34. Prasanth B, Soman A, Jobin J, Narayanan PS, John AP. Plants and phytoconstituents having sunscreen activity. World Journal of Current Medical and Pharmaceutical Research. 2020 Feb 27: 14-20.
35. Tsukahara K, Moriwaki S, Hotta M, Fujimura T, Sugiyama-Nakagiri Y, Sugawara S, Kitahara T, Takema Y. The effect of sunscreen on skin elastase activity induced by ultraviolet-A irradiation. Biological and Pharmaceutical Bulletin. 2005; 28(12): 2302-7.
36. Nogueira MA, Magalhães EG, Magalhães AF, Biloti DN, Laverde Jr A, Pessine FB, Carvalho JE, Kohn LK, Antônio MA, Marsaioli AJ. A novel sunscreen agent having antimelanoma activity. Il Farmaco. 2003 Nov 1; 58(11): 1163-9.
37. Shetty PK, Venuvanka V, Jagani HV, Chethan GH, Ligade VS, Musmade PB, Nayak UY, Reddy MS, Kalthur G, Udupa N, Rao CM. Development and evaluation of sunscreen creams containing morin-encapsulated nanoparticles for enhanced UV radiation protection and antioxidant activity. International Journal of Nanomedicine. 2015 Oct 13: 6477-91.
38. Oh JJ, Kim JY, Son SH, Jung WJ, Seo JW, Kim GH. Fungal melanin as a biocompatible broad-spectrum sunscreen with high antioxidant activity. RSC advances. 2021; 11(32): 19682-9.