Author(s):
Muhammad Hamza Ashfaq, Amna Siddique, Sammia Shahid
Email(s):
f2019140020@umt.edu.pk
DOI:
10.52711/2231-5691.2021.00021
Address:
Muhammad Hamza Ashfaq*, Amna Siddique, Sammia Shahid
Department of Chemistry, School of Science, University of Management and Technology, Lahore, Pakistan.
*Corresponding Author
Published In:
Volume - 11,
Issue - 2,
Year - 2021
ABSTRACT:
Cinnamon zeylanicum is one of the species of cinnamon plant from the family of Lauraceae. It is not only the main ingredient of spices but also exhibits many medicinal properties. Anti-microbial, anti-fungal, anti-inflammatory, anti-tyrosinase, anti-carcinogenic and anti-mutagenic are some of the activities shown by cinnamon. Radical scavenging and reducing properties of cinnamon are considered as beneficial and important in the field of medicine. Cinnamon zeylanicum consists of a variety of phenolic and flavonoid compounds in different parts of plant. These compounds play major role in antioxidant potential just because of their significant structure and moieties. Cinnamon essential oils are also used for treatment of chronic disorders and it proves to be best alternative to synthetic antioxidants. In present review article we summarized the Cinnamon zeylanicum antioxidant activity by using antioxidant assays, its chemical constituents, its beneficial effects on humans and its applications in various industries as antioxidants.
Cite this article:
Muhammad Hamza Ashfaq, Amna Siddique, Sammia Shahid. Antioxidant Activity of Cinnamon zeylanicum: (A Review). Asian Journal of Pharmaceutical Research. 2021; 11(2):106-6. doi: 10.52711/2231-5691.2021.00021
Cite(Electronic):
Muhammad Hamza Ashfaq, Amna Siddique, Sammia Shahid. Antioxidant Activity of Cinnamon zeylanicum: (A Review). Asian Journal of Pharmaceutical Research. 2021; 11(2):106-6. doi: 10.52711/2231-5691.2021.00021 Available on: https://asianjpr.com/AbstractView.aspx?PID=2021-11-2-7
REFERENCES:
1. Paur I, Carlsen MH, Halvorsen BL, Blomhoff R. Antioxidants in herbs and spices. InHerbal Medicine: Biomolecular and Clinical Aspects. 2nd edition 2011. CRC Press/Taylor & Francis.
2. Kooti W, Daraei N. A review of the antioxidant activity of celery (Apium graveolens L). Journal of evidence-based complementary & alternative medicine. 2017; 22(4): 1029-34.
3. Podsędek A, Sosnowska D, Redzynia M, Koziołkiewicz M. Effect of domestic cooking on the red cabbage hydrophilic antioxidants. International journal of food science & technology. 2008; 43(10): 1770-7.
4. Abeysekera WP, Premakumara GAS, Ratnasooriya WD. In vitro antioxidant properties of leaf and bark extracts of Ceylon cinnamon (Cinnamomum zeylanicum Blume). Tropical Agricultural Research. 2013; 24(2): 128-138.
5. Hamidpour R, Hamidpour M, Hamidpour S, Shahlari M. Cinnamon from the selection of traditional applications to its novel effects on the inhibition of angiogenesis in cancer cells and prevention of Alzheimer's disease, and a series of functions such as antioxidant, anticholesterol, antidiabetes, antibacterial, antifungal, nematicidal, acaracidal, and repellent activities. Journal of traditional and complementary medicine. 2015; 5(2): 66-70.
6. Rao PV, Gan SH. Cinnamon: a multifaceted medicinal plant. Evidence-Based Complementary and Alternative Medicine. 2014; 2014.
7. Saleem M, Bhatti HN, Jilani MI, Hanif MA. Bioanalytical evaluation of Cinnamomum zeylanicum essential oil. Natural Product Research. 2015; 29(19): 1857-9.
8. Tulini FL, Souza VB, Echalar-Barrientos MA, Thomazini M, Pallone EM and Favaro-Trindade CS. Development of solid lipid microparticles loaded with a proanthocyanidin-rich cinnamon extract (Cinnamomum zeylanicum): Potential for increasing antioxidant content in functional foods for diabetic population. Food Research International. 2016; 85: 10-8.
9. Tulini FL, Souza VB, Thomazini M, Silva MP, Massarioli AP, Alencar SM, Pallone EM, Genovese MI and Favaro-Trindade CS. Evaluation of the release profile, stability and antioxidant activity of a proanthocyanidin-rich cinnamon (Cinnamomum zeylanicum) extract co-encapsulated with α-tocopherol by spray chilling. Food Research International. 2017; 95: 117-24.
10. Suresh D, Kumar MP, Nagabhushana H, Sharma SC. Cinnamon supported facile green reduction of graphene oxide, its dye elimination and antioxidant activities. Materials Letters. 2015; 151: 93-5.
11. Pandey AK, Mishra AK, Mishra A, Kumar S, Chandra A. C. zeylanicum. Int J Biol Med Res. 2010; 1(4): 228-33.
12. Faix Š, Faixová Z, Plachá I, Koppel J. Effect of Cinnamomum zeylanicum essential oil on antioxidative status in broiler chickens. Acta Veterinaria Brno. 2009; 78(3): 411-7.
13. Ismail HF, Hashim Z, Soon WT, Ab Rahman NS, Zainudin AN and Majid FA. Comparative study of herbal plants on the phenolic and flavonoid content, antioxidant activities and toxicity on cells and zebrafish embryo. Journal of Traditional and Complementary Medicine. 2017; 7(4): 452-65.
14. Alfadda AA, Sallam RM. Reactive oxygen species in health and disease. Journal of Biomedicine and Biotechnology. 2012; 1-14.
15. Uttara B, Singh AV, Zamboni P, Mahajan RT. Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options. Current neuropharmacology. 2009; 7(1): 65-74.
16. Cooke MS, Evans MD, Dizdaroglu M, Lunec J. Oxidative DNA damage: mechanisms, mutation, and disease. The FASEB Journal. 2003; 17(10): 1195-214.
17. Halliwell B. Protection against tissue damage in vivo by desferrioxamine: what is its mechanism of action?. Free Radical Biology and Medicine. 1989; 7(6): 645-51.
18. Matkowski A. Plant in vitro culture for the production of antioxidants—a review. Biotechnology advances. 2008; 26(6): 548-60.
19. Kahl R, Kappus H. Toxicology of the synthetic antioxidants BHA and BHT in comparison with the natural antioxidant vitamin E. Zeitschrift fur Lebensmittel-untersuchung und-forschung. 1993; 196(4): 329.
20. Jayaprakasha GK, Rao LJ, Sakariah KK. Chemical composition of the volatile oil from the fruits of Cinnamomum zeylanicum Blume. Flavour and fragrance journal. 1997; 12(5): 331-3.
21. Pokorný J. Natural antioxidants for food use. Trends in Food Science & Technology. 1991; 2: 223-7.
22. Aviram M, Dornfeld L, Rosenblat M, Volkova N, Kaplan M, Coleman R, Hayek T, Presser D and Fuhrman B. Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E–deficient mice. The American journal of clinical nutrition. 2000; 71(5): 1062-76.
23. Harborne AJ. Phytochemical methods a guide to modern techniques of plant analysis. springer science & business media; 1998.
24. Ingold KU. Inhibition of oil oxidation by 2, 6-di-t-butyl-4-substituted phenols. The Journal of Physical Chemistry. 1960; 64(11): 1636-42.
25. Nanasombat S, Wimuttigosol P. Antimicrobial and antioxidant activity of spice essential oils. Food Science and Biotechnology. 2011; 20(1): 45-53.
26. Singh G, Maurya S, DeLampasona MP, Catalan CA. A comparison of chemical, antioxidant and antimicrobial studies of cinnamon leaf and bark volatile oils, oleoresins and their constituents. Food and chemical toxicology. 2007; 45(9): 1650-61.
27. El-Baroty GS, Abd El-Baky HH, Farag RS, Saleh MA. Characterization of antioxidant and antimicrobial compounds of cinnamon and ginger essential oils. African journal of biochemistry research. 2010; 4(6): 167-74.
28. Juliani HR, Simon JE, Ramboatiana MR, Behra O, Garvey A and Raskin I. Malagasy aromatic plants: Essential oils, antioxidant and antimicrobial activities. InXXVI International Horticultural Congress: The Future for Medicinal and Aromatic Plants. 2002; 77-81.
29. Jamshidi M, Barzegar M, Sahari MA. Effect of gamma and microwave irradiation on antioxidant and antimicrobial activities of Cinnamomum zeylanicum and Echinacea purpurea. International Food Research Journal. 2014; 21(4).
30. Fathiazad F, KHAKI A, NOURI M, AFSHIN KA. Effect of Cinnamon Zeylanicum on serum Testosterone and anti-oxidants levels in Rats. 2013; 29-35.
31. Shobana S, Naidu KA. Antioxidant activity of selected Indian spices. Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA). 2000; 62(2): 107-10.
32. Gauthami M, Srinivasan N, M Goud N, Boopalan K and Thirumurugan K. Synthesis of silver nanoparticles using Cinnamomum zeylanicum bark extract and its antioxidant activity. Nanoscience & Nanotechnology-Asia. 2015; 5(1): 2-7.
33. Muchuweti M, Kativu EC, Mupure CH, Chidewe C, Ndhlala AR and Benhura MA. Phenolic composition and antioxidant properties of some spices. American Journal of Food Technology. 2007; 2(5): 414-20.
34. Mancini-Filho J, Van-Koiij A, Mancini DA, Cozzolino FF and Torres RP. Antioxidant activity of cinnamon (Cinnamomum Zeylanicum, Breyne) extracts. Bollettino chimico farmaceutico. 1998; 137(11): 443.
35. Jayaprakasha GK, Ohnishi-Kameyama M, Ono H, Yoshida M and Jaganmohan Rao L. Phenolic constituents in the fruits of Cinnamomum zeylanicum and their antioxidant activity. Journal of Agricultural and Food Chemistry. 2006; 54(5): 1672-9.
36. Schmidt E, Jirovetz L, Buchbauer G, Eller GA, Stoilova I, Krastanov A, Stoyanova A and Geissler M. Composition and antioxidant activities of the essential oil of cinnamon (Cinnamomum zeylanicum Blume) leaves from Sri Lanka. Journal of essential oil-bearing plants. 2006; 9(2): 170-82.
37. Jayaprakasha GK, Rao LJ. Chemistry, biogenesis, and biological activities of Cinnamomum zeylanicum. Critical reviews in food science and nutrition. 2011; 51(6): 547-62.
38. Özcan MM, Arslan D. Antioxidant effect of essential oils of rosemary, clove and cinnamon on hazelnut and poppy oils. Food Chemistry. 2011 Nov 1;129(1):171-4.
39. Kitazuru ER, Moreira AV, Mancini-Filho J, Delincee H and Villavicencio AL. Effects of irradiation on natural antioxidants of cinnamon (Cinnamomum zeylanicum N.). Radiation Physics and Chemistry. 2004; 71(1-2): 39-41.
40. Şimşek ÜG, Ciftci M, Doğan G, Özçelik M. Antioxidant activity of cinnamon bark oil (Cinnamomum zeylanicum L.) in Japanese quails under thermo neutral and heat stressed conditions. Kafkas Univ Vet Fak Derg. 2013; 19(5): 889-94.
41. Khaki A, Bayatmakoo R, Nouri M, Khaki AA. Remedial Effect of Cinnamon zeylanicum on serum anti-oxidants levels in male diabetic Rat. Life Science Journal. 2013; 10(4s): 103-7.
42. Ranjbar A, Ghasmeinezhad S, Zamani H, Malekirad AA, Baiaty A, Mohammadirad A and Abdollahi M. Antioxidative stress potential of Cinnamomum zeylanicum in humans: a comparative cross-sectional clinical study. Clinical Practice. 2006; 3(1): 113.
43. Wong YC, Ahmad-Mudzaqqir MY, Wan-Nurdiyana WA. Extraction of essential oil from cinnamon (Cinnamomum zeylanicum). Oriental journal of chemistry. 2014; 30(1): 37-47.
44. Ervina M, Nawu YE, Esar SY. Comparison of in vitro antioxidant activity of infusion, extract and fractions of Indonesian Cinnamon (Cinnamomum burmannii) bark. International Food Research Journal. 2016; 23(3): 1346.
45. Dugoua JJ, Seely D, Perri D, Cooley K, Forelli T, Mills E and Koren G. From type 2 diabetes to antioxidant activity: a systematic review of the safety and efficacy of common and cassia cinnamon bark. Canadian journal of physiology and pharmacology. 2007; 85(9): 837-47.
46. Jayathilakan K, Sharma GK, Radhakrishna K, Bawa AS. Antioxidant potential of synthetic and natural antioxidants and its effect on warmed-over-flavour in different species of meat. Food Chemistry. 2007; 105(3): 908-16.
47. Jayaprakasha GK, Rao LJ. Chemistry, biogenesis, and biological activities of Cinnamomum zeylanicum. Critical reviews in food science and nutrition. 2011; 51(6): 547-62.
48. Sariözkan S, Türk G, Güvenç M, Yüce A, Özdamar S, Cantürk F and Yay AH. Effects of Cinnamon (C. zeylanicum) Bark oil against taxanes-induced damages in sperm quality, testicular and epididymal oxidant/antioxidant balance, testicular apoptosis, and sperm DNA integrity. Nutrition and Cancer. 2016; 68(3): 481-94.