Author(s): Tandel Jinal N., Pumbhadiya Dilipkumar A., Chauhan Payal P, Shah Samir K

Email(s): jinaltandel1202@gmail.com

DOI: 10.5958/2231-5691.2018.00001.1   

Address: Tandel Jinal N.1*, Pumbhadiya Dilipkumar A.1, Chauhan Payal P1, Shah Samir K2
1Department of Quality Assurance, Sardar Patel College of Pharmacy, Gujarat
Technological University, Bakrol, Gujarat
2Department of Pharmacology, Sardar Patel College of Pharmacy, Gujarat Technological University, Bakrol, Gujarat
*Corresponding Author

Published In:   Volume - 8,      Issue - 1,     Year - 2018


ABSTRACT:
A simple, sensitive and precise high performance liquid chromatographic method for the analysis of Ilaprazole (ILA) and Domperidone (DOM) in their combine dosage form has been developed and validated. The compounds were well separated an isocratically on a C18 Hyperchrom ODS-BP column (250 mm ?4.6 mm, 5 µm) utilizing a mobile phase consisting of methanol: phosphate buffer pH 3.5 (35:65 % v/v,) at a flow rate of 1.0 ml/min with UV detection at 281.1 nm. The retention time of ILA and DOM was found to be 3.84 min and 6.55 min. respectively. The proposed method is linear over the concentration ranges 5–15 µg/ml and 15–45 µg/ml for ILA and DOM respectively. Accurate with 99.80-100.09 % recovery for ILA and 99.40-99.77 % recovery for DOM and precise (% RSD < 2 %).The LOD were 3.38 and 4.28 µg/ml and LOQ were 10.24 and 12.99 µg/ml for ILA and DOM respectively. The method has been used to determine potency of commercial product and potency was found within limit. The method is applicable for the analysis of Ilaprazole and Domperidone in marketed formulation.


Cite this article:
Tandel Jinal N., Pumbhadiya Dilipkumar A., Chauhan Payal P, Shah Samir K. An Isocratic RP-HPLC Method for Simultaneous Analysis of Ilaprazole And Domperidone in Pharmaceutical Formulation. Asian J. Pharm. Res. 2018; 8(1): 01-05. doi: 10.5958/2231-5691.2018.00001.1


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DOI: 10.5958/2231–5691 


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