Author(s): Kavita wagh, Sandeep Sonawane, Santosh Chhaajed, Sanjay Kshirsagar

Email(s): sandeeps.iop@gmail.com

DOI: 10.5958/2231-5691.2017.00023.5   

Address: Kavita wagh, Sandeep Sonawane*, Santosh Chhaajed, Sanjay Kshirsagar
MET’S Institute of Pharmacy, Bhujbal Knowledge City, Adgaon, Nashik-422003, India
*Corresponding Author

Published In:   Volume - 7,      Issue - 3,     Year - 2017


ABSTRACT:
A single, simple, accurate and precise RP-HPLC method has been developed for the separation amlodipine besylate in presence of azilsartan medoxomil and atorvastatin calciumand estimation in their respective combined dosage forms. The chromatographic separation was achieved on C18 column (250 × 4.6 mm, 5 µ) using Acetonitrile: 20mM Phosphate buffer (pH 3) 60:40 v/v as a mobile phase at flow rate of 0.8 mL/min. The separation was achieved in isocratic mode and the detection was performed at 242 nm. Further the developed method was validated as per the ICH Q2 (R1) and applied for quantitation of atorvastatin calcium-amlodipine besylate and amlodipine besylate -azilsartan medoxomil in tablet formulations.


Cite this article:
Kavita wagh, Sandeep Sonawane, Santosh Chhaajed, Sanjay Kshirsagar. Development of RP-HPLC method for separation of atorvastatin calcium, amlodipine besylate and azilsartan medoxomil and its application to analyze their tablet dosage forms. Asian J. Pharm. Res. 2017; 7(3): 148-154. doi: 10.5958/2231-5691.2017.00023.5


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Asian Journal of Pharmaceutical Research (AJPRes.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. AJPRes. publishes Original Research Articles, Short Communications..... Read more >>>

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DOI: 10.5958/2231–5691 


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