Author(s): Kamisetti R Rajeswari, Vinitha Brungi, S. Bennuru, Sr. Cheeli, RM. Gupta Vankadari

Email(s): drkrajarajeswari@gmail.com

DOI: 10.5958/2231-5691.2020.00001.5   

Address: Kamisetti R Rajeswari, Vinitha Brungi, S. Bennuru, Sr. Cheeli, RM. Gupta Vankadari
Pulla Reddy Institute of Pharmacy, Gummadidala, Sangareddy, Dist, Telangana 502313
*Corresponding Author

Published In:   Volume - 10,      Issue - 1,     Year - 2020


ABSTRACT:
The present work was aimed to investigate the effects of ? Cyclodextrins and super disintegrants on the release of the poorly soluble BCS class II drug, Irbesartan. Orally disintegrating tablets of the drug were prepared with the inclusion complexes of the drug and various superdisintegrants. A novel no-calorie sweetening agent was added in the formulation and its effect on the drug release was also studied. Spectral studies revealed no drug-excipient compatability exist. Drug inclusion complexes using ß cyclodextrins were prepared by physical mixing, kneading and solvent evaporation methods and characterized. Complexes of 1:2 ratio were found to have better entrapment efficiency which was also confirmed by DSC and SEM. Orally disintegrating tablets were prepared by direct compression methods and evaluated for pre and post compression parameters. The optimized formulation F2 was found to have a disintegration time of 5 seconds with a cumulative percentage drug release of 97% in 60 minutes. There was no much difference in the drug release with the addition of sucralose. A comparative dissolution study of F2 with that of the pure drug, marketed formulation and formulation without superdisintegrants was performed. Hence it was concluded that solubility of Irbesartan can be enhanced using ß-cyclodextrins and the orally disintegrating tablets of the drug are suited for improving onset of action and further bioavailability.


Cite this article:
Kamisetti R Rajeswari, Vinitha Brungi, S. Bennuru, Sr. Cheeli, RM. Gupta Vankadari. Studies on the development of Orally Disintegrating Tablets of Irbesartan. Asian J. Pharm. Res. 2020; 10(1):01-07. doi: 10.5958/2231-5691.2020.00001.5


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DOI: 10.5958/2231–5691 


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