Author(s): Nachiket S. Dighe, Pankaj Shinde, Harshali Anap, Sanjay Bhawar, Deepak S. Musmade

Email(s): nachiket1111@rediffmail.com

DOI: Not Available

Address: Nachiket S. Dighe1*, Pankaj Shinde1, Harshali Anap1, Sanjay Bhawar2 and Deepak S. Musmade3
1Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni, MS, India-413736.
2Department of Pharmacology, Pravara Rural College of Pharmacy, Loni, MS, India-413736.
3Department of Pharmaceutical Chemistry, Sanjivani College of Pharmaceutical Education and Research, Kopargaon, MS, India
*Corresponding Author

Published In:   Volume - 4,      Issue - 4,     Year - 2014


ABSTRACT:
The synthesis, structure and biological activity of Oxadiazole derivatives have long been the focus of research interests in the field of Medicinal Chemistry. A number of Oxadiazole derivatives have been reported to possess interesting biological activities such as Antimicrobial, Anti-inflammatory and Antifungal activities etc. All synthesized compound were characterized by IR, H¬1-NMR and elemental Analysis. All the compounds were evaluated for Antibacterial and Anti-inflammatory at the concentration of 200 µcg/mL by using cup-plate agar diffusion method. The activity was carried out on different micro-organisms (E.coli, S. aureus, A.niger, C. albicans) measured in terms of zone of inhibition and compared the standard drug Ciprofloxacin and Amphotericin B for antimicrobial activity. All the newly synthesized derivatives were screened for Anti-inflammatory activity by an in-vitro method of Inhibition of protein denaturation using Zaltoprofen as a standard.


Cite this article:
Nachiket S. Dighe, Pankaj Shinde, Harshali Anap, Sanjay Bhawar, Deepak S. Musmade. QSAR Study and Synthesis of some new 2, 5-disubstituted 1, 3, 4-oxadiazole derivatives as Anti-microbial and Anti-inflammatory Agents. Asian J. Pharm. Res. 4(4): Oct.-Dec.2014; Page 174-179.


Recomonded Articles:

Author(s): S.K. Purohit, R. Solanki, V. Mathur, M. Mathur

DOI:         Access: Open Access Read More

Author(s): AK Meena, MM Rao, RP Meena, P Panda, Renu

DOI:         Access: Open Access Read More

Author(s): Jaseela KP, Anjan Kumar, Veeresh Babu. D, Narayana Swamy V.B

DOI: 10.5958/2231-5691.2016.00014.9         Access: Open Access Read More

Author(s): Naidu Narapusetty, O. Sivaiah, B. Balanasaraiah, M. Haranadhbabu, B. Prasad, B. Hosanna Crown, Ch. M. M. Prasada Rao

DOI: 10.5958/2231-5691.2017.00015.6         Access: Open Access Read More

Author(s): Debarshi Kar Mahapatra, Ruchi S. Shivhare, Pranesh Kumar

DOI: 10.5958/2231-5691.2018.00002.3         Access: Open Access Read More

Author(s): Ganesh Akula, Rangu Nirmala, CH. Shanthipriya, S. Rohini Reddy, A. Jaswanth

DOI: 10.5958/2231-5691.2017.00010.7         Access: Open Access Read More

Author(s): Venkateshwarlu Goli, Kanakam Vijay Bhaskar, Sravan Prasad Macharla, Jimmidi.Bhaskar, P. Suvarna Devi, T. Ramchander

DOI:         Access: Open Access Read More

Author(s): Prathap Kumar Kothapalli, Jagadeesh. S. Sanganal, N.B. Shridhar

DOI:         Access: Open Access Read More

Author(s): Uma Sankar Gorla,. M. Savithri, G.S.N. Koteswara Rao,. Y. Niharika, . P. Devi Sree Sathya, . V. Harika

DOI: 10.5958/2231-5691.2018.00006.0         Access: Open Access Read More

Author(s): Mr. Bhushan P. Gayakwad, . Shashikant D. Barhate, Prafull P. Patil, . Mayur S. Jain

DOI: 10.5958/2231-5691.2018.00009.6         Access: Open Access Read More

Author(s): T. Panneer Selvam, G. Saravanan, C. R. Prakash, P. Dinesh Kumar

DOI:         Access: Open Access Read More

Author(s): Muhammed Shakkeel K.V, Anjan Kumar, Veeresh Babu. D, Narayana Swamy V.B

DOI: 10.5958/2231-5691.2015.00021.0         Access: Open Access Read More

Author(s): G. Saravanan, V. Alagarsamy, C.R. Prakash, P. Dinesh Kumar, T. Panneer Selvam

DOI:         Access: Open Access Read More

Author(s): Ghanshyam Dhalendra, Trilochan Satapathy, Amit Roy

DOI:         Access: Open Access Read More

Author(s): Rangarajan Narasimhan, Sathiyamoorthy. M

DOI: 10.5958/2231-5691.2016.00001.0         Access: Open Access Read More

Author(s): Binoy Varghese Cheriyan, Sabartina scarlet, Priyadarshini, Shailesh joshi, Santhseelan, Sheik Mohamed

DOI: 10.5958/2231-5691.2019.00032.7         Access: Closed Access Read More

Author(s): Punasiya Rakesh, Patel Pramod, Pillai Sujit

DOI: 10.5958/2231-5691.2019.00006.6         Access: Closed Access Read More

Asian Journal of Pharmaceutical Research (AJPRes.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. AJPRes. publishes Original Research Articles, Short Communications..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231–5691 


Recent Articles




Tags