Murrayanine-Chalcone Transformed into Novel Pyrimidine Compounds Demonstrated promising Anti-Inflammatory Activity

Debarshi Kar Mahapatra; Ruchi S. Shivhare; Pranesh Kumar

doi:10.5958/2231-5691.2018.00002.3

Asian Journal of Pharmaceutical Research

ISSN

2231-5691 (Online)
2231-5683 (Print)

Submit Article

Murrayanine-Chalcone Transformed into Novel Pyrimidine Compounds Demonstrated promising Anti-Inflammatory Activity

Author(s): Debarshi Kar Mahapatra, Ruchi S. Shivhare, Pranesh Kumar

Email(s): dkmbsp@gmail.com

DOI: 10.5958/2231-5691.2018.00002.3

Address: Debarshi Kar Mahapatra1*, Ruchi S. Shivhare2, Pranesh Kumar3
1Department of Pharmaceutical Chemistry, Dadasaheb Balpande College of Pharmacy, Nagpur 440037, Maharashtra, India
2Department of Pharmaceutical Chemistry, Kamla Nehru College of Pharmacy, Nagpur 441108, Maharashtra, India
3Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University (A Central University), Lucknow 226025, Uttar Pradesh, India
*Corresponding Author

Published In: Volume - 8, Issue - 1, Year - 2018

View HTML

View PDF

ABSTRACT:
A new series of murrayanine based pyrimidine derivatives were synthesized from the previously reported starting material, known as murrayanine-chalcone and urea as the reagent in alkaline-ethanolic media. The in vivo anti-inflammatory activity of the fabricated compounds was performed by the carrageenan-induced paw edema standard method. The produced molecules were characterized using modern sophisticated analytical techniques such as IR, 1H-NMR, and mass spectral data, spectroscopic data revealed the possible structures of the synthesized compounds and characterization data were found to be in full agreement with that of the structures. The compound 6-(4-fluorophenyl)-4-(1-methoxy-9H-carbazol-3-yl)-1,6-dihydropyrimidin-2-ol (3b), having para-fluorine substituent exhibited the highest anti-inflammatory activity with 58.33% reduction after 3 hrs. The anti-inflammatory activity was observed to be reasonably analogous with that of indomethacin, the standard drug. A very clear structure-activity relationship was not established due to mixed results. It was detected that fluorine substituted compound exhibited the best activity, followed by bromine, and iodine substituent. It was also seen that while substituting the chlorine along with fluorine in the derivative, the activity fallen drastically. The introduction of bulky group did not show an impressive activity as compared to the single electron-withdrawing group. On increasing the number of substituent to double, it was found that the activity reduces severely. This research will undoubtedly encourage scientists across the globe in the rational designing and synthesis of molecules with distinct pharmacological action(s).

Keywords:

Cite this article:
Debarshi Kar Mahapatra, Ruchi S. Shivhare, Pranesh Kumar. Murrayanine-Chalcone Transformed into Novel Pyrimidine Compounds Demonstrated promising Anti-Inflammatory Activity. Asian J. Pharm. Res. 2018; 8(1): 06-10. doi: 10.5958/2231-5691.2018.00002.3

Cite(Electronic):
Debarshi Kar Mahapatra, Ruchi S. Shivhare, Pranesh Kumar. Murrayanine-Chalcone Transformed into Novel Pyrimidine Compounds Demonstrated promising Anti-Inflammatory Activity. Asian J. Pharm. Res. 2018; 8(1): 06-10. doi: 10.5958/2231-5691.2018.00002.3 Available on: https://asianjpr.com/AbstractView.aspx?PID=2018-8-1-2

Recomonded Articles:

Pharmacological and Phytochemical Evidences for the Plants of Wedelia Genus– A Review

Author(s): AK Meena, MM Rao, RP Meena, P Panda, Renu

DOI: Access: Open Access Read More

Sublingual Tablets - An Updated Review

Author(s): Ashok Thulluru, Nawaz Mahammed, C. Madhavi, K. Nandini, S. Sirisha, D. Spandana

DOI: 10.5958/2231-5691.2019.00016.9 Access: Open Access Read More

Self-nano Emulsifying Drug Delivery System (SNEDDS): Future Aspects

Author(s): Hiral A. Makadia, Ami Y. Bhatt, Ramesh B. Parmar, Ms. Jalpa S. Paun, H.M. Tank

DOI: Access: Open Access Read More

Traditional Herbs to treat Acne Vulgaris

Author(s): Sonali Syal, Vinay Pandit, M. S Ashawat

DOI: 10.5958/2231-5691.2020.00034.9 Access: Open Access Read More

Review on Pharmacological Properties of Abutilon indicum.

Author(s): Mohite M S, Shelar P A, Raje V N., Babar S. J., Sapkal R. K.

DOI: Access: Open Access Read More

Eupatorium triplinerve (Vahl): An Ethnobotanical Review

Author(s): Binoy Varghese Cheriyan, Sabartina scarlet, Priyadarshini, Shailesh joshi, Santhseelan, Sheik Mohamed

DOI: 10.5958/2231-5691.2019.00032.7 Access: Open Access Read More

A detailed investigation of phytochemical, biological and commercial utilization of horse tail tree Casuarina equisetifolia

Author(s): Vani Mamillapalli, Latha Sri Kondaveeti, Ratna Harika Chapala, Tejaswi Komal Sai. Sareddu, Santhi Pattipati, Padmalatha Khantamneni

DOI: 10.52711/2231-5691.2022.00014 Access: Open Access Read More

Study of Different Granulation Processes during Formulation Development, Evaluation, Characterization of Granules and Capsule Formulations

Author(s): Hemant Patel

DOI: Access: Open Access Read More

Design, Development and Evaluation of Enteric Coated Tablets of Glimepiride

Author(s): Rutuja S. Shah, Rutuja R. Shah, Manoj M. Nitalikar, Chandrakant S. Magdum

DOI: 10.5958/2231-5691.2017.00024.7 Access: Open Access Read More

Animal Models for Inflammation: A Review

Author(s): Ghanshyam Dhalendra, Trilochan Satapathy, Amit Roy

DOI: Access: Open Access Read More

Vitex trifolia -An Important Medicinal Plant: A Review of Its Folklore Medicine and Traditional Uses

Author(s): Goli. Venkateshwarlu, E. Ragyanaik, Kasireddy. Swapna, A. Santhosh, CH. Santhosh

DOI: Access: Open Access Read More

Introduction to Pharmacovigilance and Monitoring

Author(s): Manohar D. Kengar, Kiran K. Patole, Akshay K. Ade, Sumesh M. Kumbhar, Chetan D. Patil, Ashutosh R. Ganjave

DOI: 10.5958/2231-5691.2019.00019.4 Access: Open Access Read More

Evaluation of Wound Healing Activity of Ethanolic Extract of Curcuma longa Rhizomes in Male Albino Rats

Author(s): S.K. Purohit, R. Solanki, V. Mathur, M. Mathur

DOI: Access: Open Access Read More

Phytopharmacology of Ficus bengalensis - A Review

Author(s): Prathap Kumar Kothapalli, Jagadeesh. S. Sanganal, N.B. Shridhar

DOI: Access: Open Access Read More

Formulation and Evaluation of Cinitapride Controlled Release Tablets

Author(s): Mercy Mathew, Ravikumar, Simila Madathil, Anju Govind, Narayana Swamy VB

DOI: 10.5958/2231-5691.2016.00015.0 Access: Open Access Read More

Ethno Pharmacological Uses of Artocarpus altilis– A Review

Author(s): Vidya Raju*, Jasmine Joy Bell, Merlin. N. J, Shaiju S Dharan

DOI: 10.5958/2231-5691.2017.00037.5 Access: Open Access Read More

Formulation and Evaluation of Herbal Shampoo: Bryophyllum pinnatum

Author(s): Kavya V. Reddy, Ashish V. Yachawad, Krushna K. Zambare, Sopan Landge

DOI: 10.5958/2231-5691.2020.00016.7 Access: Open Access Read More

Anti-Inflammatory activity of Ethanolic extract of Basella alba in acute and Sub-acute Model

Author(s): Naidu Narapusetty, O. Sivaiah, B. Balanasaraiah, M. Haranadhbabu, B. Prasad, B. Hosanna Crown, Ch. M. M. Prasada Rao

DOI: 10.5958/2231-5691.2017.00015.6 Access: Open Access Read More

Effects of Anti-Inflammatory Activity of Mimosa pudica.

Author(s): Venkateshwarlu Goli, Kanakam Vijay Bhaskar, Sravan Prasad Macharla, Jimmidi.Bhaskar, P. Suvarna Devi, T. Ramchander

DOI: Access: Open Access Read More

Formulation and Characterization of Metformin Hydrochloride Floating Tablets

Author(s): Ashok A. Hajare, Vrushali A. Patil

DOI: Access: Open Access Read More

Asian Journal of Pharmaceutical Research (AJPRes.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. AJPRes. publishes Original Research Articles, Short Communications..... Read more >>>

RNI: Not Available
DOI: 10.5958/2231–5691