Author(s): Dheeraj Singh, Vishal Kaundal, Neha Aggarwal, Shammy Jindal, Amar Deep Ankalgi, Kamya Goyal

Email(s): kamya.goyal7@gmail.com

DOI: 10.52711/2231-5691.2022.00007   

Address: Dheeraj Singh1, Vishal Kaundal1, Neha Aggarwal1, Shammy Jindal2, Amar Deep Ankalgi1, Kamya Goyal1*
1Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog, H.P., India.
2Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, H.P., India.
*Corresponding Author

Published In:   Volume - 12,      Issue - 1,     Year - 2022


ABSTRACT:
Chalcones and their derivatives have been an area of great interest in recent years. Numbers of research publications have been published and chalcones continue to show promising effect for new drug investigations. Chalcone is an advantageous species with medicinal importance as it is consisting of highly reactive ketoethylenic system –CO–CH=CH– which belongs to flavonoids. Chalcones (1, 3-Diphenyl-2-propen-1-one) consists of a three carbon a, ß-unsaturated carbonyl system and two or more aromatic rings and acts as precursors for the biosynthesis of flavonoids in plants. However, synthesis in laboratory of broad range of chalcones has also been reported. In chalcone and its derivatives, a highly reactive a, ß-unsaturated carbonyl system is the major reason for their pharmacological potencies. Chalcones and their derivatives are known to show a wide range of pharmacological potencies such as anti-inflammatory, antioxidant, antileishmanial, antifungal, anticancer, antibacterial, antiulcer, antiprotozoal, antitumor, antimalarial, antidiabetic, anthelmintic, insecticidal, antigout, antihistaminic, antiviral, antimycobacterial etc. Chalcones can be prepared by Claisen–Schmidt’s condensation, Aldol condensation, Heck’s reaction, Suzuki’s reaction, Ultrasound method of synthesis, Solvent free synthesis of chalcones, One pot synthesis, Sonogashira Isomerization coupling reaction etc. The purpose of the present review is to focus on the various methods of preparation of chalcones and derivatives and their anti-inflammatory and antioxidant potencies.


Cite this article:
Dheeraj Singh, Vishal Kaundal, Neha Aggarwal, Shammy Jindal, Amar Deep Ankalgi, Kamya Goyal. A Concise Review on Synthesis, Anti-inflammatory and Antioxidant Activities of Chalcone. Asian Journal of Pharmaceutical Research. 2022; 12(1):37-4. doi: 10.52711/2231-5691.2022.00007

Cite(Electronic):
Dheeraj Singh, Vishal Kaundal, Neha Aggarwal, Shammy Jindal, Amar Deep Ankalgi, Kamya Goyal. A Concise Review on Synthesis, Anti-inflammatory and Antioxidant Activities of Chalcone. Asian Journal of Pharmaceutical Research. 2022; 12(1):37-4. doi: 10.52711/2231-5691.2022.00007   Available on: https://asianjpr.com/AbstractView.aspx?PID=2022-12-1-7


REFERENCES:
1.    Awasthi SK, Mishra N, Kumar B, Sharma M, Bhattacharya A, Mishra LC, Bhasin VK. Potent antimalarial activity of newly synthesized substituted chalcone analogs in vitro. Medicinal Chemistry Research. 2009;18(6):407-20.
2.    Cheng MS, Li RS, Kenyon G. A solid phase synthesis of chalcones by Claisen-Schmidt condensations. Chinese Chemical Letters. 2000;11(10):851-4.
3.    Liu M, Wilairat P, Go ML. Antimalarial alkoxylated and hydroxylated chalones: structure− activity relationship analysis. Journal of Medicinal Chemistry. 2001;44(25):4443-52.
4.    Straub TS. Epoxidation of α, β-unsaturated ketones with sodium perborate. Tetrahedron letters. 1995;36(5):663-4.
5.    Dhar R, Kimseng R, Chokchaisiri R, Hiransai P, Utaipan T, Suksamrarn A, Chunglok W. 2′, 4-Dihydroxy-3′, 4′, 6′-trimethoxychalcone from Chromolaena odorata possesses anti-inflammatory effects via inhibition of NF-κB and p38 MAPK in lipopolysaccharide-activated RAW 264.7 macrophages. Immunopharmacology and Immunotoxicology. 2018;40(1):43-51.
6.    Fu ZY, Jin QH, Qu YL, Guan LP. Chalcone derivatives bearing chromen or benzo [f] chromen moieties: Design, synthesis, and evaluations of anti-inflammatory, analgesic, selective COX-2 inhibitory activities. Bioorganic & Medicinal Chemistry Letters. 2019;29(15):1909-12.
7.    Gan FF, Zhang R, Ng HL, Karuppasamy M, Seah W, Yeap WH, Ong SM, Hadadi E, Wong SC, Chui WK, Chew EH. Novel dual-targeting anti-proliferative dihydrotriazine-chalcone derivatives display suppression of cancer cell invasion and inflammation by inhibiting the NF-κB signaling pathway. Food and Chemical Toxicology. 2018;116:238-48.
8.    Li J, Li D, Xu Y, Guo Z, Liu X, Yang H, Wu L, Wang L. Design, synthesis, biological evaluation, and molecular docking of chalcone derivatives as anti-inflammatory agents. Bioorganic & medicinal chemistry letters. 2017;27(3):602-6.
9.    Mahapatra DK, Bharti SK, Asati V. Chalcone derivatives: anti-inflammatory potential and molecular targets perspectives. Current Topics in Medicinal Chemistry. 2017;17(28):3146-69.
10.    Idris MM, Amin SM, Selvaraj M, Jamari H, Kek TL, Salleh MZ. High-Throughput Structure-Based Drug Design of Chalcones Scaffolds as Dual Inhibitor of Cyclooxygenase-2 and Microsomal Prostaglandin E Synthase-1. Journal of Pharmaceutical Sciiences and Emerging Drugs. 2018;6(01).
11.    Sayed M, Kamal El‐Dean AM, Ahmed M, Hassanien R. Synthesis, Characterization, and Screening for Anti‐inflammatory and Antimicrobial Activity of Novel Indolyl Chalcone Derivatives. Journal of Heterocyclic Chemistry. 2018;55(5):1166-75.
12.    Bandgar BP, Patil SA, Gacche RN, Korbad BL, Hote BS, Kinkar SN, Jalde SS. Synthesis and biological evaluation of nitrogen-containing chalcones as possible anti-inflammatory and antioxidant agents. Bioorganic & Medicinal Chemistry Letters. 2010;20(2):730-3.
13.    Goyal K, Kaur R, Goyal A, Awasthi R. Chalcones: A review on synthesis and pharmacological activities. Journal of Applied Pharmaceutical Science. 2021;1(Supp 1):001–014.
14.    Pingaew R, Saekee A, Mandi P, Nantasenamat C, Prachayasittikul S, Ruchirawat S, Prachayasittikul V. Synthesis, biological evaluation and molecular docking of novel chalcone–coumarin hybrids as anticancer and antimalarial agents. European Journal of Medicinal Chemistry. 2014;85:65-76.
15.    Baviskar B, Patel S, Baviskar B, Khadabadi SS, Shiradkar M. Design and synthesis of some novel chalcones as potent antimicrobial agent. Asian Journal of Research in Chemistry. 2008;1(2):67-9.
16.    Al-Mosawi SK, Al-Hazam HA, Abbas AF. Synthesis, Characterization and Biological Study of Some Chalcones derived from Terphthaldehyde. Asian Journal of Research in Chemistry. 2019;12(3):153-6.
17.    Benouda H, Bouchal B, Challioui A, Oulmidi A, Harit T, Malek F, Riahi A, Bellaoui M, Bouammali B. Synthesis of a Series of Chalcones and Related Flavones and Evaluation of their Antibacterial and Antifungal Activities. Letters in Drug Design & Discovery. 2019;16(1):93-100.
18.    Lal K, Yadav P, Kumar A, Kumar A, Paul AK. Design, synthesis, characterization, antimicrobial evaluation and molecular modeling studies of some dehydroacetic acid-chalcone-1, 2, 3-triazole hybrids. Bioorganic chemistry. 2018;77:236-44.
19.    Monga V, Goyal K, Steindel M, Malhotra M, Rajani DP, Rajani SD. Synthesis and evaluation of new chalcones, derived pyrazoline and cyclohexenone derivatives as potent antimicrobial, antitubercular and antileishmanial agents. Medicinal Chemistry Research. 2014;23(4):2019-32.
20.    Mokle SS, Sayyed MA, Vibhute AY, Khansole SV, Nalwar YS, Vibhute YB. Synthesis of Some New Bioactive Chalcones and Flavones. Research Journal of Pharmacy and Technology. 2009;2(4):846-9.
21.    Shahare HV, Pawar GR, Patil SS, Patil PD. Synthesis and Biological Evaluation of New Chalcone Analogs. Asian Journal of Research in Chemistry. 2011;4(2):237-40.
22.    Lunkad AS, Kothawade SN, Jadhav DV, Chaudhari PS, Bornare SP. Synthesis and Antimicrobial Activity of Some New Chalcones Containing Benzofuran and Benzofuran Schiff Bases. Research Journal of Pharmacy and Technology. 2015;8(3):276.
23.    Bhat KI and Kumar A. Synthesis and Biological Evaluation of Some Novel Pyrazoline Derivatives Derived from Chalcones. Research Journal of Pharmacy and Technology. 2017;10(5):1344-1346.
24.    Dawane BS, Shaikh BM, Khandare NT, Mandawad GG, Chobe SS, Konda SG. Synthesis of Some Novel Substituted Pyrazole Based Chalcones and Their In-Vitro Antimicrobial Activity. Asian Journal of Research in Chemistry. 2010;3(1):90-3.
25.    Narwal S, Kumar S, Verma PK. Synthesis and biological activity of new chalcone scaffolds as prospective antimicrobial agents. Research on Chemical Intermediates. 2021;47:1625–1641
26.    Prabhakar V, Babu KS, Ravindranath LK, Basha MS, Latha J. Application of Chalcones in Synthesis of Novel 1, 5-Benzodiazepine Derivatives Containing Thieno [2, 3-d] Pyrimidine Core Unit and its Biological Activity Screening. Asian Journal of Research in Chemistry. 2017;10(2):71-84.
27.    Beena KP, Rajesh P, Nathiya S. Synthesis of some novel substituted isoxazoline based chalcones and their in-vitro antimicrobial activity. Asian Journal of Research in Chemistry. 2010;3(4):1080-2.
28.    Özdemir A, Altıntop MD, Sever B, Gençer HK, Kapkaç HA, Atlı Ö, Baysal M. A new series of pyrrole-based chalcones: synthesis and evaluation of antimicrobial activity, cytotoxicity, and genotoxicity. Molecules. 2017;22(12):2112.
29.    Singh PP, Jayalakshmi B, Kumar NS. Synthesis, Characterization and Antimicrobial Evaluation of Some New Chalcones. Asian Journal of Research in Chemistry. 2013;6(12):1133-6.
30.    Wan Z, Hu D, Li P, Xie D, Gan X. Synthesis, antiviral bioactivity of novel 4-thioquinazoline derivatives containing chalcone moiety. Molecules. 2015;20(7):11861-74.
31.    Padaratz P, Fracasso M, De Campos‐Buzzi F, Corrêa R, Niero R, Monache FD, Cechinel‐Filho V. Antinociceptive activity of a new benzofuranone derived from a chalcone. Basic & Clinical Pharmacology & Toxicology. 2009;105(4):257-61.
32.    Rossi GV, Avellino JD. An evaluation of the antihistaminic activity of a new series of chalcone derivatives. American Journal of Pharmacy and the Sciences Supporting Public Health. 1957;129(9):324-31.
33.    N Choudhary A, Kumar A, Juyal V. Design, synthesis and evaluation of chalcone derivatives as anti-inflammatory, antioxidant and antiulcer agents. Letters in Drug Design & Discovery. 2012;9(5):479-88.
34.    Balu P, Jas JS, Govindaraj M. Design and evaluation of chalconeimine derivatives as α-amylase inhibitors. Bioinformation. 2019;15(7):523.
35.    Emayavaramban M, Santhi N, Gopi C, Manivannan C, Raguraman A. Synthesis, Characterization and Anti-diabetic activity of 1, 3, 5-triaryl-2-pyrazolines in acetic acid solution under Ultrasound Irradiation. International Letters of Chemistry, Physics and Astronomy. 2013;9:172-85.
36.    Gaur R, Yadav KS, Verma RK, Yadav NP, Bhakuni RS. In vivo anti-diabetic activity of derivatives of isoliquiritigenin and liquiritigenin. Phytomedicine. 2014;21(4):415-22.
37.    Hsieh CT, Hsieh TJ, El-Shazly M, Chuang DW, Tsai YH, Yen CT, Wu SF, Wu YC, Chang FR. Synthesis of chalcone derivatives as potential anti-diabetic agents. Bioorganic & Medicinal Chemistry Letters. 2012;22(12):3912-5.
38.    Rammohan A, Reddy JS, Sravya G, Rao CN, Zyryanov GV. Chalcone synthesis, properties and medicinal applications: a review. Environmental Chemistry Letters. 2020;18(2):433-58.
39.    Shukla P, Satyanarayana M, Verma PC, Tiwari J, Dwivedi AP, Srivastava R, Rehuja N, Srivastava SP, Gautam S, Tamrakar AK, Dwivedi AK. Chalcone-based aryloxypropanolamine as a potential antidiabetic and antidyslipidaemic agent. Current Science. 2017:1675-89.
40.    Hsieh CY, Ko PW, Chang YJ, Kapoor M, Liang YC, Chu HL, Lin HH, Horng JC, Hsu MH. Design and synthesis of benzimidazole-chalcone derivatives as potential anticancer agents. Molecules. 2019;24(18):3259.
41.    Khanapure S, Jagadale M, Bansode P, Choudhari P, Rashinkar G. Anticancer activity of ruthenocenyl chalcones and their molecular docking studies. Journal of Molecular Structure. 2018;1173:142-7.
42.    Sashidhara KV, Kumar A, Kumar M, Sarkar J, Sinha S. Synthesis and in vitro evaluation of novel coumarin–chalcone hybrids as potential anticancer agents. Bioorganic & Medicinal Chemistry Letters. 2010;20(24):7205-11.
43.    Sharma A, Anghore D, Awasthi R, Kosey S, Jindal S, Gupta N, Raj D, Sood R. A Review on Current Carbon Nanomaterials and Other Nanoparticles Technology and Their Applications in Biomedicine. World Journal Pharmacy and Pharmaceutical Science. 2015;4(12):1088-113.
44.    Hofmann E, Webster J, Do T, Kline R, Snider L, Hauser Q, Higginbottom G, Campbell A, Ma L, Paula S. Hydroxylated chalcones with dual properties: Xanthine oxidase inhibitors and radical scavengers. Bioorganic & Medicinal Chemistry. 2016;24(4):578-87.
45.    Insuasty B, Ramírez J, Becerra D, Echeverry C, Quiroga J, Abonia R, Robledo SM, Vélez ID, Upegui Y, Muñoz JA, Ospina V. An efficient synthesis of new caffeine-based chalcones, pyrazolines and pyrazolo [3, 4-b][1, 4] diazepines as potential antimalarial, antitrypanosomal and antileishmanial agents. European Journal of Medicinal Chemistry. 2015;93:401-13.
46.    K Sahu N, S Balbhadra S, Choudhary J, V Kohli D. Exploring pharmacological significance of chalcone scaffold: a review. Current Medicinal Chemistry. 2012;19(2):209-25.
47.    Higuchi K, Watanabe T, Tanigawa T, Tominaga K, Fujiwara Y, Arakawa T. Sofalcone, a gastroprotective drug, promotes gastric ulcer healing following eradication therapy for Helicobacter pylori: A randomized controlled comparative trial with cimetidine, an H2‐receptor antagonist. Journal of Gastroenterology and Hepatology. 2010;25:S155-60.
48.    Weindorf N, Schultz-Ehrenburg U. Controlled study of increasing venous tone in primary varicose veins by oral administration of Ruscus aculeatus and trimethylhespiridinchalcone. Zeitschrift fur Hautkrankheiten. 1987;62(1):28-38.
49.    Beltramino R, Penenory A, Buceta AM. A open-label, randomised multicentre study comparing the efficacy and safety of CYCLO 3 FORT versus hydroxyethyl rutoside in chronic venous lymphatic insufficiency. International Angiology. 1999;18(4):337.
50.    Beltramino R, Penenory A, Buceta AM. An open-label, randomized multicenter study comparing the efficacy and safety of Cyclo 3 Fort® versus hydroxyethyl rutoside in chronic venous lymphatic insufficiency. Angiology. 2000;51(7):535-44.
51.    Liu Y, Lund JA, Murch SJ, Brown PN. Single-lab validation for determination of kavalactones and flavokavains in Piper methysticum (Kava). Planta Medica. 2018;84(16):1213-8.
52.    Pinner KD, Wales CT, Gristock RA, Vo HT, So N, Jacobs AT. Flavokawains A and B from kava (Piper methysticum) activate heat shock and antioxidant responses and protect against hydrogen peroxide-induced cell death in HepG2 hepatocytes. Pharmaceutical Biology. 2016;54(9):1503-12.
53.    Echeverria C, Santibañez JF, Donoso-Tauda O, Escobar CA, Ramirez-Tagle R. Structural antitumoral activity relationships of synthetic chalcones. International Journal of Molecular Sciences. 2009;10(1):221-31.
54.    Kolot C, Rodriguez-Mateos A, Feliciano R, Bottermann K, Stahl W. Bioavailability of naringenin chalcone in humans after ingestion of cherry tomatoes. International Journal for Vitamin and Nutrition Research. 2019; 90(5–6):411–6.
55.    Slimestad R, Verheul M. Properties of chalconaringenin and rutin isolated from cherry tomatoes. Journal of Agricultural and Food Chemistry. 2011;59(7):3180-5.
56.    Gerhauser C. Cancer chemopreventive potential of apples, apple juice, and apple components. Planta Medica. 2008;74(13):1608-24.
57.    Mariadoss AV, Vinyagam R, Rajamanickam V, Sankaran V, Venkatesan S, David E. Pharmacological aspects and potential use of phloretin: A systemic review. Mini Reviews in Medicinal Chemistry. 2019;19(13):1060-7.
58.    Min J, Li X, HuANG KE, Tang H, Ding X, Qi C, Qin X, Xu ZH. Phloretin induces apoptosis of non-small cell lung carcinoma A549 cells via JNK1/2 and p38 MAPK pathways. Oncology Reports. 2015;34(6):2871-9.
59.    Reiland H, Slavin J. Systematic review of pears and health. Nutrition Today. 2015;50(6):301.
60.    Sasaki C, Ichitani M, Kunimoto KK, Asada C, Nakamura Y. Extraction of arbutin and its comparative content in branches, leaves, stems, and fruits of Japanese pear Pyrus pyrifolia cv. Kousui. Bioscience, Biotechnology, and Biochemistry. 2014;78(5):874-7.
61.    Vashishtha M, Mishra M, Shah DO. Study on catalytic property of NaOH-cationic surfactant solutions for efficient, green and selective synthesis of flavanone. Journal of Molecular Liquids. 2015;210:151-9.
62.    Sharma R, Kumar K, Chouhan M, Grover V, Nair VA. Lithium hydroxide mediated synthesis of 3, 4-disubstituted pyrroles. RSC Advances. 2013;3(34):14521-7.
63.    Yang W, Miao T, Li P, Wang L. Regioselective synthesis of triazoles via base-promoted oxidative cycloaddition of chalcones with azides in aqueous solution. RSC Advances. 2015;5(116):95833-9.
64.    Sie CZ, Ngaini Z, Suhaili N, Madiahlagan E. Synthesis of kojic ester derivatives as potential antibacterial agent. Journal of Chemistry. 2018;2018.
65.    Miyahara Y, Ito YN. AlCl3-mediated aldol cyclocondensation of 1, 6-and 1, 7-diones to cyclopentene and cyclohexene derivatives. The Journal of Organic Chemistry. 2014;79(15):6801-7.
66.    Ritter M, Martins RM, Rosa SA, Malavolta JL, Lund RG, Flores AF, Pereira CM. Green synthesis of chalcones and microbiological evaluation. Journal of the Brazilian Chemical Society. 2015;26(6):1201-10.
67.    Liu F, Yang JF, Liu H, Wei WZ, Ma YM. Facile Microwave‐assisted Synthesis of 1, 3, 5‐Trisubstituted Pyrazoline Derivatives Incorporating Sulfonyl Moiety. Journal of the Chinese Chemical Society. 2016;63(3):254-60.
68.    Nimkar A, Ramana MM, Betkar R, Ranade P, Mundhe B. CsOH/γ-Al2O3: A heterogeneous reusable basic catalyst for one-pot synthesis of 2-amino-4, 6-diaryl pyrimidines. New Journal of Chemistry. 2016;40(3):2541-6.
69.    Rafiee E, Rahimi F. A green approach to the synthesis of chalcones via Claisen-Schmidt condensation reaction using cesium salts of 12-tungstophosphoric acid as a reusable nanocatalyst. Monatshefte für Chemie-Chemical Monthly. 2013;144(3):361-7.
70.    Rafiee E, Rahimi F. Synthesis of biologically active chalcon analogues via Claisen-Schmidt Condensation in solvent-free conditions: supported mixed addenda heteropoly acid as a heterogeneous catalyst. Journal of the Chilean Chemical Society. 2013;58(3):1926-9.
71.    Sathiyamoorthi K, Mala V, Sakthinathan SP, Kamalakkannan D, Suresh R, Vanangamudi G, Thirunarayanan G. Solvent-free synthesis, spectral correlations and antimicrobial activities of some aryl E 2-propen-1-ones. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2013;112:245-56.
72.    Sinhamahapatra A, Pal P, Tarafdar A, Bajaj HC, Panda AB. Mesoporous borated zirconia: a solid acid–base bifunctional catalyst. ChemCatChem. 2013;5(1):331-8.
73.    Sultan A, Raza AR, Abbas M, Khan KM, Tahir MN, Saari N. Evaluation of silica-H2SO4 as an efficient heterogeneous catalyst for the synthesis of chalcones. Molecules. 2013;18(8):10081-94.
74.    Morrison RT, Boyd RN. Organic Chemistry, 6th edn., Pearson Education Publishers. 2004; 971–990, 997–1020
75.    Eddarir S, Cotelle N, Bakkour Y, Rolando C. An efficient synthesis of chalcones based on the Suzuki reaction. Tetrahedron Letters. 2003;44(28):5359-63.
76.    Selepe MA, Van Heerden FR. Application of the Suzuki-Miyaura reaction in the synthesis of flavonoids. Molecules. 2013;18(4):4739-65.
77.    Bianco A, Cavarischia C, Farina A, Guiso M, Marra C. A new synthesis of flavonoids via Heck reaction. Tetrahedron Letters. 2003;44(51):9107-9.
78.    Jagdale AR, Sudalai A. p-Toluenesulfonic acid mediated hydroarylation of cinnamic acids with anisoles and phenols under metal and solvent-free conditions. Tetrahedron Letters. 2007;48(28):4895-8.
79.    Abe I, Sano Y, Takahashi Y, Noguchi H. Site-directed mutagenesis of benzalacetone synthase: the role of Phe215 in plant type III polyketide synthases. Journal of Biological Chemistry. 2003;278(27):25218-26.
80.    Rothenberg G, Downie AP, Raston CL, Scott JL. Understanding solid/solid organic reactions. Journal of the American Chemical Society. 2001;123(36):8701-8.
81.    Siddiqui ZN. A convenient synthesis of coumarinyl chalcones using HClO4–SiO2: A green approach. Arabian Journal of Chemistry. 2019;12(8):2788-97.
82.    Rajesh UC, Purohit G, Rawat DS. One-pot synthesis of aminoindolizines and chalcones using CuI/CSP nanocomposites with anomalous selectivity under green conditions. ACS Sustainable Chemistry & Engineering. 2015;3(10):2397-404.
83.    Wei W, Qunrong W, Liqin D, Aiqing Z, Duoyuan W. Synthesis of dinitrochalcones by using ultrasonic irradiation in the presence of potassium carbonate. Ultrasonics Sonochemistry. 2005;12(6):411-4.
84.    Adole VA, Jagdale BS, Pawar TB, Sagane AA. Ultrasound promoted stereoselective synthesis of 2, 3-dihydrobenzofuran appended chalcones at ambient temperature. South African Journal of Chemistry. 2020;73:35-43.
85.    Calvino V, Picallo M, López-Peinado AJ, Martín-Aranda RM, Durán-Valle CJ. Ultrasound accelerated Claisen–Schmidt condensation: A green route to chalcones. Applied Surface Science. 2006;252(17):6071-4.
86.    Cancio N, Costantino AR, Silbestri GF, Pereyra MT. Ultrasound-Assisted Syntheses of Chalcones: Experimental Design and Optimization. InMultidisciplinary Digital Publishing Institute Proceedings 2019 (Vol. 41, No. 1, p. 13).
87.    Li JT, Yang WZ, Wang SX, Li SH, Li TS. Improved synthesis of chalcones under ultrasound irradiation. Ultrasonics Sonochemistry. 2002;9(5):237-9.
88.    Polo E, Ibarra-Arellano N, Prent-Peñaloza L, Morales-Bayuelo A, Henao J, Galdámez A, Gutiérrez M. Ultrasound-assisted synthesis of novel chalcone, heterochalcone and bis-chalcone derivatives and the evaluation of their antioxidant properties and as acetylcholinesterase inhibitors. Bioorganic Chemistry. 2019;90:103034.
89.    Braun RU, Ansorge M, Müller TJ. Coupling–Isomerization synthesis of chalcones. Chemistry–A European Journal. 2006;12(35):9081-94.
90.    Won SJ, Liu CT, Tsao LT, Weng JR, Ko HH, Wang JP, Lin CN. Synthetic chalcones as potential anti-inflammatory and cancer chemopreventive agents. European Journal of Medicinal Chemistry. 2005;40(1):103-12.
91.    Zhao F, Nozawa H, Daikonnya A, Kondo K, Kitanaka S. Inhibitors of nitric oxide production from hops (Humulus lupulus L.). Biological and Pharmaceutical Bulletin. 2003;26(1):61-5.
92.    Ito Y, Miyake Y, Okada K, inventors Maruzen Pharmaceuticals Co. Ltd., assignee. Reduced chalcone compound and method of producing the same, reduced product of fat-soluble licorice root extract and method of producing the same, cyclooxygenase-2 activity inhibitor, whitening agent, antiinflammatory agent and cosmetic. WO. 2007;2007052330:A1.
93.    Bano S, Javed K, Ahmad S, Rathish IG, Singh S, Chaitanya M, Arunasree KM, Alam MS. Synthesis of some novel chalcones, flavanones and flavones and evaluation of their anti-inflammatory activity. European Journal of Medicinal Chemistry. 2013;65:51-9.
94.    Özdemir A, Altıntop MD, Turan-Zitouni G, Çiftçi GA, Ertorun İ, Alataş Ö, Kaplancıklı ZA. Synthesis and evaluation of new indole-based chalcones as potential antiinflammatory agents. European Journal of Medicinal Chemistry. 2015;89:304-9.
95.    Bandgar BP, Hote BS, Dhole NA, Gacche RN. Synthesis and biological evaluation of novel series of chalcone derivatives as inhibitors of cyclooxygenase and LPS-induced TNF-α with potent antioxidant properties. Medicinal Chemistry Research. 2012;21(9):2292-9.
96.    Jadhav SY, Bhosale RB, Shirame S, Sonawane VD, Hublikar MG, Sonawane KD, Shaikh RU. Synthesis and biological evaluation of fluoro-hydroxy substituted pyrazole chalcones as anti-inflammatory, antioxidant and antibacterial agents. International Journal of Pharma and Bio Sciences. 2013;4(2):390–397.
97.    Nyandoro SS, Nkunya MH, Josepha CC, Odalo JO, Sattler I. New Glucopyranosylglyceryl-N-Octenyl Adipate and Bioactivity of Retro and Condensed Chalcones from Toussaintia Orientalis. Tanzania Journal of Science. 2012;38(3):108-26.
98.    Yadav HL, Gupta P, Pawar RS, Singour PK, Patil UK. Synthesis and biological evaluation of anti-inflammatory activity of 1, 3 diphenyl propenone derivatives. Medicinal Chemistry Research. 2011;20(4):461-5.
99.    Jantan I, Bukhari SN, Adekoya OA, Sylte I. Studies of synthetic chalcone derivatives as potential inhibitors of secretory phospholipase A2, cyclooxygenases, lipoxygenase and pro-inflammatory cytokines. Drug Design, Development and Therapy. 2014;8:1405.
100.    Bukhari SN, Ahmad W, Butt AM, Ahmad N, Amjad MW, Hussain MA, Shah VH, Trivedi AR. Synthesis and evaluation of chalcone analogues and pyrimidines as cyclooxygenase (COX) inhibitors. African Journal of Pharmacy and Pharmacology. 2012;6(14):1064-8.
101.    Zhang XW, Zhao DH, Quan YC, Sun LP, Yin XM, Guan LP. Synthesis and evaluation of anti-inflammatory activity of substituted chalcone derivatives. Medicinal Chemistry Research. 2010;19(4):403-12.
102.    Hasan SA, Elias AN, Jwaied AH, Khuodaer AR, Hussain SA. Synthesis of new fluorinated chalcone derivative with anti-inflammatory Activity. International Journal of Pharmacy and Pharmaceutical Sciences. 2012;4(5):430-4.
103.    Akhtar MS, Rehman AU, Arshad H, Malik A, Fatima M, Tabassum T, Raza AR, Bukhsh M, Murtaza MA, Mehmood MH, Sultan A. In Vitro Antioxidant Activities and the Therapeutic Potential of Some Newly Synthesized Chalcones Against 4-Acetaminophenol Induced Hepatotoxicity in Rats. Dose-Response. 2021;19(1):1559325821996955.
104.    Aly MR, Fodah HH, Saleh SY. Antiobesity, antioxidant and cytotoxicity activities of newly synthesized chalcone derivatives and their metal complexes. European Journal of Medicinal Chemistry. 2014;76:517-30.
105.    Sivakumar PM, Prabhakar PK, Doble M. Synthesis, antioxidant evaluation, and quantitative structure–activity relationship studies of chalcones. Medicinal Chemistry Research. 2011;20(4):482-92.
106.    Miranda CL, Stevens JF, Ivanov V, McCall M, Frei B, Deinzer ML, Buhler DR. Antioxidant and prooxidant actions of prenylated and nonprenylated chalcones and flavanones in vitro. Journal of Agricultural and Food Chemistry. 2000;48(9):3876-84.
107.    Kumar CS, Loh WS, Ooi CW, Quah CK, Fun HK. Structural correlation of some heterocyclic chalcone analogues and evaluation of their antioxidant potential. Molecules. 2013;18(10):11996-2011.
108.    Lahsasni SA, Al Korbi FH, Aljaber NA. Synthesis, characterization and evaluation of antioxidant activities of some novel chalcones analogues. Chemistry Central Journal. 2014;8(1):1-10.
109.    Qian YP, Shang YJ, Teng QF, Chang J, Fan GJ, Wei X, Li RR, Li HP, Yao XJ, Dai F, Zhou B. Hydroxychalcones as potent antioxidants: structure–activity relationship analysis and mechanism considerations. Food Chemistry. 2011;126(1):241-8.
110.    Murti Y, Goswam A, Mishra P. Synthesis and antioxidant activity of some chalcones and flavanoids. International Journal of PharmTech Research. 2013;5:811-8.

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