Author(s): Jude Chigozie Ikewuchi, Catherine Chidinma Ikewuchi and Mercy Onuekwuzu Ifeanacho

Email(s): ecoli240733@yahoo.com

DOI: Not Available

Address: Jude Chigozie Ikewuchi*, Catherine Chidinma Ikewuchi and Mercy Onuekwuzu Ifeanacho
Department of Biochemistry, Faculty of Chemical Sciences, College of Natural and Applied Sciences, University of Port Harcourt, P.M.B. 5323, Port Harcourt, Nigeria.
*Corresponding Author

Published In:   Volume - 4,      Issue - 1,     Year - 2014


ABSTRACT:
The ability of aqueous extract of Chromolaena odorata leaves to moderate plasma chemistry and hematological indices was investigated in sub-chronic salt-loaded rats. The normal and treatment control groups received a diet consisting 100% of commercial feed, while the test control, reference and test treatment groups received an 8% salt-loaded diet. The extract (100 and 200 mg kg-1 body weight) and moduretics (1 mg kg-1 body weight) were orally administered daily. The normal and test control groups orally received appropriate volumes of water. The extract was screened for bioactive phytochemicals, using gas chromatography-coupled flame ionization detector. Three known glycosides (mainly arbutin, 99.95%), four known saponins (mainly avenacin B-1, 85.80%), three allicins (mainly diallyl thiosulphinate, 84.16%) and forty two alkaloids (mainly indicine-N-oxide, 51.02%) were detected. Also detected were twenty four known terpenes (mainly limonene, 74.26%), eight benzoic acid derivatives (mainly ferulic acid, 86.83%) and eight lignans (mainly retusin, 71.80%). Compared to test control, the extract dose-dependently, significantly lowered (P<0.05) neutrophils and monocytes counts, mean cell hemoglobin, mean cell hemoglobin concentration, plasma activities of alanine and aspartate transaminases, and concentrations of sodium, urea, total protein and bicarbonate. However, it significantly increased (P<0.05) platelets, red cells, total white cells and lymphocytes counts, plasma levels of creatinine, potassium, chloride, calcium and albumin corrected calcium. These results suggest that the leaves antihypertensive action may be mediated via alteration of plasma sodium and potassium levels or changes in muscle tone orchestrated by changes in plasma calcium levels.


Cite this article:
An Aqueous Extract of the Leaves of Chromolaena odorata Moderated Plasma Biochemical and Hematological Indices of Sub-Chronic Salt-Loaded Rats. Asian J. Pharm. Res. 4(1): Jan.-Mar. 2014; Page 24-35.


Recomonded Articles:

Author(s): Rutuja S. Shah, Rutuja R. Shah, Manoj M. Nitalikar, Chandrakant S. Magdum

DOI: 10.5958/2231-5691.2017.00028.4         Access: Open Access Read More

Author(s): Akhil Gupta, Anuj Mittal , Alok Kumar Gupta

DOI:         Access: Open Access Read More

Author(s): Injamamul Haque, Ravikumar, Narayanaswamy VB, Mohibul Hoque

DOI: 10.5958/2231-5691.2016.00023.X         Access: Open Access Read More

Author(s): Rutuja S. Shah, Rutuja R. Shah, Manoj M. Nitalikar, Chandrakant S. Magdum

DOI: 10.5958/2231-5691.2017.00024.7         Access: Open Access Read More

Author(s): Neha Meshram, Mithlesh Ojha, Ajay Singh, Amit Alexander, Ajazuddin, Mukesh Sharma

DOI: 10.5958/2231-5691.2015.00009.X         Access: Open Access Read More

Author(s): Dilip M. Kumbhar, Vijay D. Havaldar, Kailas K. Mali, Remeth J. Dias, Vishwajeet S. Ghorpade, Rahul B. Londhe

DOI: 10.5958/2231-5691.2017.00002.8         Access: Open Access Read More

Author(s): Shiv Kumar Gupta, Anuradha Singh, Babita Kumar, Bharti Sharma

DOI: 10.5958/2231-5691.2017.00012.0         Access: Open Access Read More

Author(s): Uma Sankar Gorla,. M. Savithri, G.S.N. Koteswara Rao,. Y. Niharika, . P. Devi Sree Sathya, . V. Harika

DOI: 10.5958/2231-5691.2018.00006.0         Access: Open Access Read More

Author(s): Girish Pai K., Vamshi Krishna T., Lalit Kumar, M. Sreenivasa Reddy, G. Shreenidhi, A. Praneeth Reddy

DOI:         Access: Open Access Read More

Author(s): Gawai Mamata N., Aher Smita S, Saudager Ravindra B.

DOI:         Access: Open Access Read More

Author(s): Indu Sharma, Bharat Parashar, Hitesh Kumar Dhamija , Ritu sharma

DOI:         Access: Open Access Read More

Author(s): Jude Chigozie Ikewuchi, Catherine Chidinma Ikewuchi and Mercy Onuekwuzu Ifeanacho

DOI:         Access: Open Access Read More

Author(s): Venkateswarlu G*1,Manoranjan S1, Sharada N1, Sravan Prasad M2, Azeez MD1, Rajeshwari.E

DOI:         Access: Open Access Read More

Author(s): Rangarajan Narasimhan, Sathiyamoorthy. M

DOI: 10.5958/2231-5691.2016.00001.0         Access: Open Access Read More

Author(s): Valli G, Jeyalakshmi M.

DOI:         Access: Open Access Read More

Author(s): P. S. Patil, S. R. Kumbhoje, S.S. Patil

DOI: 10.5958/2231-5691.2015.00018.0         Access: Open Access Read More

Asian Journal of Pharmaceutical Research (AJPRes.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. AJPRes. publishes Original Research Articles, Short Communications..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231–5691 


Recent Articles




Tags