The present work was aimed to develop novel oral antihypertensive sustained release intestinal mucoadhesive tablets of valsartan using novel natural polymer Gum olibanum and chitosan. The tablets were prepared by using different concentration of polymer of gum olibanum and chitosan by wet granulation method. Two factor three levels central composite design applied to optimize the formulation variables. In this study Gum olibanum and chitosan were selected as independent variables. The percentage drug release, Ex-vivo residence time and Mucoadhesive strength were selected as dependant variables. Prepared formulation were evaluated for various physical and chemical parameters. In- vitro drug release study was carried out for 12 hours. Formulation F2 was given as best batch by DOE software. Formulation F2 showed 96.23% drug release at 12 hours, Ex-vivo residence time was found upto 12 hours and mucoadhesive strength was found to be 26.50(Dyne/cm2). The best fit model for F2 was found to be first order with r2 value 0.9785 mechanism of drug release was found to be fickian diffusion. Hence finally we conclude that valsartan tablet is suitable for mucoadhesive drug delivery system.
Cite this article:
Shailesh H. Lunkad, Surajj Sarode. Formulation and Evaluation of Mucoadhesive Tablet of Valsartan. Asian J. Pharm. Res. 2019; 9(4):229-237. doi: 10.5958/2231-5691.2019.00037.6