Author(s): Ravindra B. Saudagar, Nachiket S. Dighe, Deepak S. Musmade, Vinayak M. Gaware, D. A. Jain

Email(s): ravisaudagaur@yahoo.com

DOI: Not Available

Address: Ravindra B. Saudagar1*, Nachiket S. Dighe2, Deepak S. Musmade3 , Vinayak M. Gaware4 and D. A. Jain5
1Department of Pharmaceutical Chemistry, R.G.Sapkal College of Pharmacy, Nashik, M.S. India.
2Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni, MS, India-413736.
3Department of Pharmaceutical Chemistry, Sanjivani College of Pharmaceutical Education and Research, Kopargaon, MS. India.
4Department of Pharmaceutical Chemistry, College of Pharmacy, Chincholi, MS, India.
5Department of Pharmaceutical Sciences and Research, Bhagwant University, Ajmer, Rajasthan, India
*Corresponding Author

Published In:   Volume - 1,      Issue - 4,     Year - 2011


ABSTRACT:
Selective estrogen receptor modulators are the class of a chemical compounds acting on a estrogen receptors. These are selectively inhibit or stimulate the estrogen like actions in various tissues. SERMs play a key role in breast cancer chemoprevention. These agents antagonize estrogens in some tissues and mimic their action in others. The mechanism for tissue selectivity appears to be related to differences in their molecular and three-dimensional structures, which affect the transcriptional activity of the activated estrogen receptor. For example, tamoxifen and toremifene act as estrogen antagonists in breast tissue and as estrogen agonists in the endometrium. The present review article is directed towards highlighting the importance of SERMs in treatment of breast cancer.


Cite this article:
Ravindra B. Saudagar, Nachiket S. Dighe, Deepak S. Musmade , Vinayak M. Gaware, D. A. Jain. SERM’s in Treatment of Breast Cancer. Asian J. Pharm. Res. 1(4): Oct. - Dec. 2011; Page 81-86.


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Asian Journal of Pharmaceutical Research (AJPRes.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. AJPRes. publishes Original Research Articles, Short Communications..... Read more >>>

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DOI: 10.5958/2231–5691 


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