Author(s): Sanket Ramesh Gayke, Samruddhi Subhash Adsul, Madhuri Sanjay Wable, Waghmare Sweeti Mohan

Email(s): gaykesanket@gmail.com

DOI: 10.52711/2231-5691.2026.00012   

Address: Sanket Ramesh Gayke, Samruddhi Subhash Adsul, Madhuri Sanjay Wable, Waghmare Sweeti Mohan
Shantiniketan College of Pharmacy, Dhotre, Taluka – Parner, District – Ahmednagar.
*Corresponding Author

Published In:   Volume - 16,      Issue - 1,     Year - 2026


ABSTRACT:
Wild sage, or Lantana camara var. aculeata Moldenke, is a woody perennial plant that grows naturally in tropical and subtropical areas. It was first brought to India as a decorative plant, but it has since spread far and invaded a variety of environments. The morphology, reproductive biology, phytochemical composition, traditional usage, and wide range of medicinal activity of the plant are all well covered in this review. In preclinical research, several L. camara extracts have shown strong antibacterial, anti-inflammatory, antioxidant, anticancer, antidiabetic, hepatoprotective, and antiparasitic properties. Its medicinal qualities are influenced by substances like triterpenoids, flavonoids, oleanonic acid, and essential oils. To improve distribution and efficacy, formulations such as gels, ointments, nanogels, and transdermal patches have been created. However, despite these promising activities, toxicological studies reveal potential risks at high doses, including hepatotoxicity, immunosuppression, and alterations in biochemical parameters, particularly in animal models. Morphological and phytochemical variations due to polyploidy and geographic origin add complexity to its standardization. Future research must focus on isolating bioactive constituents, understanding mechanisms of action, evaluating long-term safety, and conducting human clinical trials. While L. camara holds vast therapeutic promise, responsible use requires a balance between efficacy and safety, particularly when considering its integration into modern and traditional medicine.


Cite this article:
Sanket Ramesh Gayke, Samruddhi Subhash Adsul, Madhuri Sanjay Wable, Waghmare Sweeti Mohan. Lantana camara: A Pharmacological Powerhouse with Toxicological Challenges – A Comprehensive. Asian Journal of Pharmaceutical Research. 2026; 16(1):90-6. doi: 10.52711/2231-5691.2026.00012

Cite(Electronic):
Sanket Ramesh Gayke, Samruddhi Subhash Adsul, Madhuri Sanjay Wable, Waghmare Sweeti Mohan. Lantana camara: A Pharmacological Powerhouse with Toxicological Challenges – A Comprehensive. Asian Journal of Pharmaceutical Research. 2026; 16(1):90-6. doi: 10.52711/2231-5691.2026.00012   Available on: https://asianjpr.com/AbstractView.aspx?PID=2026-16-1-12


REFERENCES:
1.    Negi GC, Sharma S, Vishvakarma SC, Samant SS, Maikhuri RK, Prasad RC, Palni LM. Ecology and use of Lantana camara in India. The Botanical Review. 2019 Jun 15;85(2):109-30.
2.    Khaleel TF, Nalini AS. Embryology of Lantana aculeata Linn. var. nivea Bailey. Current Science. 1972 Jul 5;41(13):491-4.
3.    Khoshoo TN, MAHAL C. Versatile reproduction in Lantana camara. Current Science. 1967 Apr 20;36(8):201-3.
4.    Microflora BS, Hills TA. Master of Science (Agriculture).
5.    Zhou N, Simonneau F, Thouroude T, Oyant LH, Foucher F. Morphological studies of rose prickles provide new insights. Horticulture Research. 2021 Dec 1;8.
6.    Alexander A. The seed detective: Uncovering the secret histories of remarkable vegetables. Chelsea Green Publishing; 2022 Sep 29.
7.    Negi GC, Sharma S, Vishvakarma SC, Samant SS, Maikhuri RK, Prasad RC, Palni LM. Ecology and use of Lantana camara in India. The Botanical Review. 2019 Jun 15;85(2):109-30.
8.    Malaviya DR, Roy AK, Kaushal P. Rangelands/Grasslands of India: Current status and future prospects. Grasslands of the World. 2018 Sep 5:235-52.
9.    Malaviya DR, Roy AK, Kaushal P. Rangelands/Grasslands of India: Current status and future prospects. Grasslands of the World. 2018 Sep 5:235-52.
10.    Negi GC, Sharma S, Vishvakarma SC, Samant SS, Maikhuri RK, Prasad RC, Palni LM. Ecology and use of Lantana camara in India. The Botanical Review. 2019 Jun 15;85(2):109-30.
11.    Karle T. Celebration of Flowers. Lulu. com; 2011 Jun 20.
12.    Vijaya S, Maddala VK, Narkhede S, Iqbal MN. Botany: Taxonomy of Angiosperm And Biodiversity. Academic Guru Publishing House; 2024 Dec 24.
13.    Es s. Preliminary Analysis of Floristic Diversity in Selected Wards of Cheranelloor Panchayat (Doctoral Dissertation, St Teresa's (Autonomous), Ernakulam).
14.    Musinya IR. Antimicrobial Activity, Toxicity and Phytochemical Screening of Lantana Trifolia Leaf Extracts (Doctoral dissertation, University of Nairobi).
15.    Carter RB. Differentiating analgesic and non-analgesic drug activities on rat hot plate: effect of behavioral endpoint. Pain. 1991 Nov 1;47(2):211-20.
16.    Stephen H, Bello B. Protective Effect of Lantana camara Methanolic Leaf Extract Against Acetaminophen-induced Liver Injury in Male Albino Rats. Pharmaceutical and Biomedical Research. 2024; 10 (2): 135-146 [Internet]. 2024
17.    Mansoori A, Singh N, Dubey SK, Thakur TK, Alkan N, Das SN, Kumar A. Phytochemical characterization and assessment of crude extracts from Lantana camara L. for antioxidant and antimicrobial activity. Frontiers in Agronomy. 2020 Nov 12;2:582268.
18.    Sousa EO, Almeida TS, Rodrigues FF, Campos AR, Lima SG, Costa JG. Lantana montevidensis Briq improves the aminoglycoside activity against multiresistant Escherichia coli and Staphylococcus aureus. Indian Journal of Pharmacology. 2011 Mar 1;43(2):180-2.
19.    Shamsee ZR, Al-Saffar AZ, Al-Shanon AF, Al-Obaidi JR. Cytotoxic and cell cycle arrest induction of pentacyclic triterpenoides separated from Lantana camara leaves against MCF-7 cell line in vitro. Molecular Biology Reports. 2019 Feb 1;46(1):381-90.
20.    Saparia HH. Isolation and Characterization of Chemical Constituents of Aerial Parts of Lantana Camara (Master's thesis, Rajiv Gandhi University of Health Sciences (India)).
21.    Hoang TC, Nguyen MT, Nguyen TQ, Ho BT, Nguyen HT, Ngo TP, Tran HN, Bui TK. In vitro anti-leukemia, antioxidant, and anti-inflammatory properties of Lantana camara. Brazilian Journal of Biology. 2024 May 27;84:e279899.
22.    Stephen H, Bello B. Protective effect of lantana camara methanolic leaf extract against acetaminophen-induced liver injury in male albino rats. Pharmaceutical and Biomedical Research. 2024 Mar 10;10(2):135-46.
23.    Subash KR. The anthelmintic activity of Eupatorium triplinerve and Alpinia galanga in Pheritima posthuma and Ascardia galli: A Comparative study.
24.    Girme AS, Bhalke RD, Ghogare PB, Tambe VD, Jadhav RS, Nirmal SA. Comparative in vitro anthelmintic activity of Mentha piperita and Lantana camara from Western India. Dhaka University Journal of Pharmaceutical Sciences. 2006;5(1):5-7.
25.    Orji EA, Orji CT, Ezechukwu CS, Egba SI. Anti-trypanosomal and hepato-toxicity potentials of Lantana camara (Verbenaceae) leaf extracts in albino rats challenged with Trypanosoma brucei. Tropical Journal of Natural Product Research. 2025 May 1;9(5).
26.    Girish K. Antimicrobial activities of Lantana camara Linn. Asian Journal of Pharmaceutical and Clinical Research. 2017;10(3):57-67.
27.    Górniak I, Bartoszewski R, Króliczewski J. Comprehensive review of antimicrobial activities of plant flavonoids. Phytochemistry Reviews. 2019 Feb 15;18(1):241-72.
28.    Sapunyo WL. Phytochemical Composition, Toxic Effects, and Antimicrobial Activity Studies of Digitaria Abyssinica (a. Rich.) Stapf (Poaceae) Rhizome Extracts Against Selected Uropathogenic Microorganisms (Doctoral dissertation, University of Nairobi).
29.    Ballabh B, Chaurasia OP. Traditional medicinal plants of cold desert Ladakh—used in treatment of cold, cough and fever. Journal of Ethnopharmacology. 2007 Jun 13;112(2):341-9.
30.    Mbah CA, Okonkwo SC, Nwaume EJ, Olawoore FR, Abah EI. Traditional African Medicinal Plants as Potential Sources of Anticancer Agents: Bioactive Compounds, Mechanisms, and Future Directions.
31.    Markus MB. Do hypnozoites cause relapse in malaria?. Trends in Parasitology. 2015 Jun 1;31(6):239-45.
32.    Pour BM, Latha LY, Sasidharan S. Cytotoxicity and oral acute toxicity studies of Lantana camara leaf extract. Molecules. 2011 May 3;16(5):3663-74.
33.    Anoosha G. Liver Function Abnormalities and its Prognostic Significance in–Malaria (Doctoral dissertation, Rajiv Gandhi University of Health Sciences (India)).
34.    Soren p. Toxicopathological Effects of sub-Chronic Exposure to Lantadenes of Lantana Camaraand Amelioration with Herbal Plants in Guinea pigs (Doctoral dissertation, Indian Veterinary Research Institute).
35.    Ghisalberti EL. Detection and isolation of bioactive natural products. InBioactive Natural Products 2007 Dec 14 (pp. 25-90). CRC Press.
36.    Olatunde A, Nigam M, Singh RK, Panwar AS, Lasisi A, Alhumaydhi FA, Jyoti Kumar V, Mishra AP, Sharifi-Rad J. Cancer and diabetes: the interlinking metabolic pathways and repurposing actions of antidiabetic drugs. Cancer Cell International. 2021 Sep 17;21(1):499.
37.    Singh D, Cho WC, Upadhyay G. Drug-induced liver toxicity and prevention by herbal antioxidants: an overview. Frontiers in Physiology. 2016 Jan 26;6:363.
38.    Singh D, Cho WC, Upadhyay G. Drug-induced liver toxicity and prevention by herbal antioxidants: an overview. Frontiers in Physiology. 2016 Jan 26;6:363.
39.    Singh LS. Developing nanocarrier-based formulations of antidiabetic drugs derived from medicinal plants: A systemic review. Pharmacological Research-Natural Products. 2024 Mar 1; 2:100004. 

Recomonded Articles:

Author(s): C. Muralikrishna Goud, Syeda Mariya Ghazanfar

DOI: 10.52711/2231-5691.2021.00025         Access: Open Access Read More

Author(s): R. R. Shah, S. A. Mohite, N. R. Patel

DOI: 10.5958/2231-5691.2018.00007.2         Access: Open Access Read More

Author(s): Sonali Syal, Vinay Pandit, M. S Ashawat

DOI: 10.5958/2231-5691.2020.00034.9         Access: Open Access Read More

Author(s): AK Meena, MM Rao, RP Meena, P Panda, Renu

DOI:         Access: Open Access Read More

Author(s): Mohite M S, Shelar P A, Raje V N., Babar S. J., Sapkal R. K.

DOI:         Access: Open Access Read More

Author(s): Mohammad Shamim Qureshi, A. Venkateshwar Reddy, G. S. Kumar, Lubna Nousheen

DOI: 10.5958/2231-5691.2017.00017.X         Access: Open Access Read More

Author(s): Vani Mamillapalli, Latha Sri Kondaveeti, Ratna Harika Chapala, Tejaswi Komal Sai. Sareddu, Santhi Pattipati, Padmalatha Khantamneni

DOI: 10.52711/2231-5691.2022.00014         Access: Open Access Read More

Author(s): Binoy Varghese Cheriyan, Sabartina scarlet, Priyadarshini, Shailesh joshi, Santhseelan, Sheik Mohamed

DOI: 10.5958/2231-5691.2019.00032.7         Access: Open Access Read More

Author(s): Neha Meshram, Mithlesh Ojha, Ajay Singh, Amit Alexander, Ajazuddin, Mukesh Sharma

DOI: 10.5958/2231-5691.2015.00009.X         Access: Open Access Read More

Author(s): Ghanshyam Dhalendra, Trilochan Satapathy, Amit Roy

DOI:         Access: Open Access Read More

Author(s): Goli. Venkateshwarlu, E. Ragyanaik, Kasireddy. Swapna, A. Santhosh, CH. Santhosh

DOI:         Access: Open Access Read More

Author(s): Vivekanandan Kalaiselvan, G. Aishwarya, Ashish Sharma

DOI: 10.52711/2231-5691.2021.00032         Access: Open Access Read More

Author(s): Preeti Tiwari

DOI:         Access: Open Access Read More

Author(s): Prathap Kumar Kothapalli, Jagadeesh. S. Sanganal, N.B. Shridhar

DOI:         Access: Open Access Read More

Author(s): S.K. Purohit, R. Solanki, V. Mathur, M. Mathur

DOI:         Access: Open Access Read More

Author(s): N. S. Patil, K. B. Patil, M. R. Patil, R. A. Ahirrao

DOI: 10.5958/2231-5691.2018.00037.0         Access: Open Access Read More

Author(s): Muhammad Hamza Ashfaq, Amna Siddique, Sammia Shahid

DOI: 10.52711/2231-5691.2021.00021         Access: Open Access Read More

Author(s): Govind Navale, Dipak D. Patil, Aashutosh A. Patil, Ketan B. Patil, Narendra B. Patil

DOI: 10.5958/2231-5691.2019.00026.1         Access: Open Access Read More

Author(s): Venkateshwarlu Goli, Kanakam Vijay Bhaskar, Sravan Prasad Macharla, Jimmidi.Bhaskar, P. Suvarna Devi, T. Ramchander

DOI:         Access: Open Access Read More


Recent Articles




Tags