Author(s):
Sonal P. Kumbhar, Pratiksha A. Satpute, Akash Thombare, Shalini Shinde, N. B. Chougule
Email(s):
sonalkumbhar05@gmail.com , pratikshasatpute22@gmail.com
DOI:
10.52711/2231-5691.2025.00020
Address:
Sonal P. Kumbhar1, Pratiksha A. Satpute2, Akash Thombare1, Shalini Shinde1, N. B. Chougule3
1Assistant Professor, Ashokrao Mane Institute of Pharmacy, Ambap, 416112.
2Student, Ashokrao Mane Institute of Pharmacy, Ambap. 416112.
3Principal5, Ashokrao Mane Institute of Pharmacy, Ambap. 416112.
2Assistant Professor, Womens College of Pharmacy, Peth-Vadgaon 416112.
*Corresponding Author
Published In:
Volume - 15,
Issue - 2,
Year - 2025
ABSTRACT:
Utilising docking of molecules and ADMET research, this investigation explores the possibility of Nigella sativa, or black seed, as a treatment for osteoporosis. Osteoporosis is a huge global public health concern since it considerably raises the menace of fractures and causes a diminution in bone density. Despite existing treatments, there remains a need for novel therapeutic agents with improved efficacy and safety profiles. Nigella sativa, renowned for its diverse pharmacological properties, emerges as a promising candidate for osteoporosis management. Through molecular docking analysis, the interaction between bioactive compounds present in Nigella sativa and key osteoporosis-related targets, like activator ofkappa-? ligand receptor and osteoprotegerin was explored. The results reveal potential binding affinities and binding modes, suggesting the ability of Nigella sativa constituents to modulate osteoporosis-related pathways. Additionally, ADMET predictions provide valuable insights into the pharmacokinetic and toxicity profiles of Nigella sativa compounds.
Cite this article:
Sonal P. Kumbhar, Pratiksha A. Satpute, Akash Thombare, Shalini Shinde, N. B. Chougule. Molecular Docking and Admet Studies of Nigella sativa Plant against Osteoporosis. Asian Journal of Pharmaceutical Research. 2025; 15(2):121-6. doi: 10.52711/2231-5691.2025.00020
Cite(Electronic):
Sonal P. Kumbhar, Pratiksha A. Satpute, Akash Thombare, Shalini Shinde, N. B. Chougule. Molecular Docking and Admet Studies of Nigella sativa Plant against Osteoporosis. Asian Journal of Pharmaceutical Research. 2025; 15(2):121-6. doi: 10.52711/2231-5691.2025.00020 Available on: https://asianjpr.com/AbstractView.aspx?PID=2025-15-2-5
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