Author(s):
Nitin Kumar, Neetika Lal, Vishal Nemaysh, Pratibha Mehta Luthra
Email(s):
nitinvishnoi@gmail.com
DOI:
10.52711/2231-5691.2024.00057 
Address:
Nitin Kumar, Neetika Lal, Vishal Nemaysh, Pratibha Mehta Luthra
Dr. B. R. Ambedkar Center for Biomedical Research, University of Delhi, New Delhi 110007, India.
*Corresponding Author
Published In:
Volume - 14,
Issue - 4,
Year - 2024
ABSTRACT:
Tricyclic carbazole derivatives displayed excellent anticancer activities in literature. In this research work, we synthesized a series of some novel substituted carbazole carbamate derivatives and also evaluated their anticancer activity (IC50) against human glioma U87MG cell line. Both 6th position and N-ethyl substituted carbazole carbamate derivatives synthesized and tested for anticancer potential on human glioma U87MG cell line based on colorimetric MTT assay. SAR (structure activity relationship) study of all substituted carbazole carbamate derivatives also elaborated on the basis of in vitro anticancer activity (IC50) results. Four carbazole integrated carbamates (27, 28, 30, 31) possesses excellent anticancer profile with IC50 values 17.97 µM, 15.25 µM, 29.58 µM, and 23.80 µM respectively on U87MG glioma cell line. Both 6-substituted and N-ethyl based carbazole carbamate compounds displayed excellent in vitro anticancer activity on tested glioma cell line. The study of novel substituted carbazole tethered carbamate derivatives found potential anticancer profile against U87MG glioma cell line and can be fruitful for further development against brain tumour.
Cite this article:
Nitin Kumar, Neetika Lal, Vishal Nemaysh, Pratibha Mehta Luthra. Synthesis and In vitro anticancer activity of some novel substituted carbazole carbamate derivatives against human glioma U87MG cell line. Asian Journal of Pharmaceutical Research.2024; 14(4):363-8. doi: 10.52711/2231-5691.2024.00057
Cite(Electronic):
Nitin Kumar, Neetika Lal, Vishal Nemaysh, Pratibha Mehta Luthra. Synthesis and In vitro anticancer activity of some novel substituted carbazole carbamate derivatives against human glioma U87MG cell line. Asian Journal of Pharmaceutical Research.2024; 14(4):363-8. doi: 10.52711/2231-5691.2024.00057 Available on: https://asianjpr.com/AbstractView.aspx?PID=2024-14-4-3
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