Author(s):
Melica Khatri, Sonam Dhar, Paul Ven, Arjun Singh
Email(s):
arjunphar@gmail.com
DOI:
10.52711/2231-5691.2024.00030
Address:
Melica Khatri1, Sonam Dhar1, Paul Ven1, Arjun Singh*2
1Department of Pharmacognosy, School of Pharmaceutical Sciences, Bhagwant University, Sikar Road, Ajmer, Rajasthan 305004, India.
2Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, United States.
*Corresponding Author
Published In:
Volume - 14,
Issue - 2,
Year - 2024
ABSTRACT:
Anticancer resistance remains a major obstacle in achieving successful outcomes in cancer treatment. Understanding the pharmacological mechanisms underlying resistance is crucial for developing effective strategies to overcome it. This article provides a comprehensive overview of the various pharmacological mechanisms contributing to anticancer resistance, including drug efflux pumps, altered drug targets, drug metabolism and inactivation, DNA repair and damage response, activation of alternative signaling pathways, the tumor microenvironment, epithelial-mesenchymal transition, and cancer stem cells. The article discusses the future directions in this field, such as combination therapies, personalized medicine, immunotherapy, novel drug delivery systems, and biomarker development. Combining multiple strategies and adopting a personalized approach is essential to overcome anticancer resistance and improve treatment outcomes.
Cite this article:
Melica Khatri, Sonam Dhar, Paul Ven, Arjun Singh. Understanding the Pharmacological Mechanisms of Anticancer Resistance: A Multifaceted Challenge in Cancer Treatment. Asian Journal of Pharmaceutical Research. 2024; 14(2):183-7. doi: 10.52711/2231-5691.2024.00030
Cite(Electronic):
Melica Khatri, Sonam Dhar, Paul Ven, Arjun Singh. Understanding the Pharmacological Mechanisms of Anticancer Resistance: A Multifaceted Challenge in Cancer Treatment. Asian Journal of Pharmaceutical Research. 2024; 14(2):183-7. doi: 10.52711/2231-5691.2024.00030 Available on: https://asianjpr.com/AbstractView.aspx?PID=2024-14-2-15
REFERENCES:
1. Kishor Lohiya. Overview on Osmotically Controlled Drug Delivery System. Res. J. Pharm. Dosage Form. and Tech. 2017; 9(2): 67-70.
2. Sirisha. S. A Review on Delivery of Anti-Cancer Drugs by Smart Nanocarriers: Data Obtained from Past One Decade. Res. J. Pharma. Dosage Forms and Tech. 2020; 12(3): 185-190.
3. Yogita R Mandlik. Immunotherapy, A type of Cancer Treatment. Res. J. Pharma. Dosage Forms and Tech. 2020; 12(4): 282-284.
4. Rajendra Jangde. Magnetically Modulated Drug Delivery Systems: An Overview. Research J. Pharm. and Tech. 2011; 4(11): 1649-1657.
5. Sanchana V.B. Mucoadhesive Disk used for the Relief of Dry Mouth. Research J. Pharm. and Tech. 2014; 7(10): 1181-1183.
6. Gautam, Y., Dwivedi, S., Srivastava, A., Hamidullah, Singh, A., Chanda, D., Singh, J., Rai, S., Konwar, R., Negi, A.S., 2-(3′,4′-Dimethoxybenzylidene) tetralone induces anti-breast cancer activity through microtubule stabilization and activation of reactive oxygen species. RSC Adv. 2016; 6: 33369–33379.
7. Hamid, A.A., Hasanain, M., Singh, A., Bhukya, B., Omprakash, Vasudev, P.G., Sarkar, J., Chanda, D., Khan, F., Aiyelaagbe, O.O., Negi, A.S., Synthesis of novel anticancer agents through opening of spiroacetal ring of diosgenin. Steroids. 2014; 87: 108–118.
8. Hamid, A.A., Kaushal, T., Ashraf, R., Singh, A., Chand Gupta, A., Prakash, O., Sarkar, J., Chanda, D., Bawankule, D.U., Khan, F., Shanker, K., Aiyelaagbe, O.O., Negi, A.S., (22β,25R)-3β-Hydroxy-spirost-5-en-7-iminoxy-heptanoic acid exhibits anti-prostate cancer activity through caspase pathway. Steroids. 2017; 119: 43–52.
9. Jain, S., Singh, A., Khare, P., Chanda, D., Mishra, D., Shanker, K., Karak, T., Toxicity assessment of Bacopa monnieri L. grown in biochar amended extremely acidic coal mine spoils. Ecological Engineering. 2017; 108: 211–219.
10. Khwaja, S., Fatima, K., Hasanain, M., Behera, C., Kour, A., Singh, A., Luqman, S., Sarkar, J., Chanda, D., Shanker, K., Gupta, A.K., Mondhe, D.M., Negi, A.S., Antiproliferative efficacy of curcumin mimics through microtubule destabilization. European Journal of Medicinal Chemistry. 2018; 151: 51–61.
11. Kumar, B.S., Ravi, K., Verma, A.K., Fatima, K., Hasanain, M., Singh, A., Sarkar, J., Luqman, S., Chanda, D., Negi, A.S., Synthesis of pharmacologically important naphthoquinones and anticancer activity of 2-benzyllawsone through DNA topoisomerase-II inhibition. Bioorganic and Medicinal Chemistry. 2017; 25: 1364–1373.
12. Mishra, D., Jyotshna, Singh, A., Chanda, D., Shanker, K., Khare, P., Potential of di-aldehyde cellulose for sustained release of oxytetracycline: A pharmacokinetic study. International Journal of Biological Macromolecules. 2019; 136: 97–105.
13. Sathish Kumar, B., Kumar, A., Singh, J., Hasanain, M., Singh, A., Fatima, K., Yadav, D.K., Shukla, V., Luqman, S., Khan, F., Chanda, D., Sarkar, J., Konwar, R., Dwivedi, A., Negi, A.S., Synthesis of 2-alkoxy and 2-benzyloxy analogues of estradiol as anti-breast cancer agents through microtubule stabilization. European Journal of Medicinal Chemistry. 2014a; 86: 740–751.
14. Sathish Kumar, B., Singh, Aastha, Kumar, A., Singh, J., Hasanain, M., Singh, Arjun, Masood, N., Yadav, D.K., Konwar, R., Mitra, K., Sarkar, J., Luqman, S., Pal, A., Khan, F., Chanda, D., Negi, A.S., Synthesis of neolignans as microtubule stabilisers. Bioorganic and Medicinal Chemistry. 2014b; 22: 1342–1354.
15. Singh, A., Mohanty, I., Singh, J., Rattan, S., BDNF augments rat internal anal sphincter smooth muscle tone via RhoA/ROCK signaling and nonadrenergic noncholinergic relaxation via increased NO release. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2020; .318: G23–G33.
16. Singh, A., Rattan, S., BDNF rescues aging-associated internal anal sphincter dysfunction. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2021; 321: G87–G97.
17. Singh, A., Singh, J., Rattan, S., Evidence for the presence and release of BDNF in the neuronal and non‐neuronal structures of the internal anal sphincter. Neurogastroenterology and Motility. 2021.
18. Singh, Aastha, Fatima, K., Singh, Arjun, Behl, A., Mintoo, M.J., Hasanain, M., Ashraf, R., Luqman, S., Shanker, K., Mondhe, D.M., Sarkar, J., Chanda, D., Negi, A.S., Anticancer activity and toxicity profiles of 2-benzylidene indanone lead molecule. European Journal of Pharmaceutical Sciences. 2015; 76: 57–67.
19. Singh, Aastha, Fatima, K., Srivastava, A., Khwaja, S., Priya, D., Singh, Arjun, Mahajan, G., Alam, S., Saxena, A.K., Mondhe, D.M., Luqman, S., Chanda, D., Khan, F., Negi, A.S., Anticancer activity of gallic acid template-based benzylidene indanone derivative as microtubule destabilizer. Chem Biol Drug Des. 2016; 88: 625–634.
20. Manmohan, S., Arjun, S., Khan, S. P., Eram, S., and Sachan, N. K., Green chemistry potential for past, present and future perspectives. International Research Journal of Pharmacy. 2012; 3: 31-36.
21. Singh, A., R. Sharma, K. M. Anand, S. P. Khan, and N. K. Sachan. Food-drug interaction. International Journal of Pharmaceutical and Chemical Science. 2012; 1(1): 264-279.
22. Arjun Singh. A Review of various aspects of the Ethnopharmacological, Phytochemical, Pharmacognostical, and Clinical significance of selected Medicinal plants. Asian Journal of Pharmacy and Technology. 2022; 12(4): 349-0. doi: 10.52711/2231-5713.2022.00055
23. Devender Paswan, Urmila Pande, Alka Singh, Divya Sharma, Shivani Kumar, Arjun Singh. Epidemiology, Genomic Organization, and Life Cycle of SARS CoV-2. Asian Journal of Nursing Education and Research. 2023; 13(2):141-4.
24. Arjun Singh, Rupendra Kumar, Sachin Sharma. Natural products and Hypertension: Scope and role in Antihypertensive Therapy. Asian Journal of Nursing Education and Research. 2023; 13(2): 162-6.
25. Arjun Singh. A Review of various aspects of the Ethnopharmacological, Phytochemical, Pharmacognostical, and Clinical significance of selected Medicinal plants. Asian Journal of Pharmacy and Technology. 2022; 12(4): 349-360. doi: 10.52711/2231-5713.2022.00055
26. Arjun Singh, Rupendra Kumar. An Overview on Ethnopharmacological, Phytochemical, and Clinical Significance of Selected Dietary Polyphenols. Asian Journal of Research in Chemistry. 2023; 16(1):8-2.
27. Arjun Singh. Plant-based Isoquinoline Alkaloids: A Chemical and Pharmacological Profile of Some Important Leads. Asian Journal of Research in Chemistry. 2023; 16(1):43-8.
28. Arjun Singh. Withaniasomnifera (L.) Ashwagandha: A Review on Ethnopharmacology, Phytochemistry, Biomedicinal and Traditional uses. Asian Journal of Pharmacy and Technology. 2023; 13(3):213-7. doi: 10.52711/2231-5713.2023.00038
29. Kaman Kumar, Pooja Singh, Divya Sharma, Akanksha Singh, Himanshu Gupta, Arjun Singh. Prospective Current Novel Drug Target for the Identification of Natural Therapeutic Targets for Alzheimer's Disease. Asian Journal of Pharmacy and Technology. 2023; 13(3): 171-4. doi: 10.52711/2231-5713.2023.00030
30. Arijita Singla, Varsha Singh, Komal Kumari, Sonam Pathak, Arjun Singh. Natural Marine Anticancer compounds and their derivatives used in Clinical Trials. Asian Journal of Pharmacy and Technology. 2023; 13(3): 235-9. doi: 10.52711/2231-5713.2023.00042
31. Arjun Singh. An Overview on Phytoestrogen based antihypertensive agent for their potential Pharmacological Mechanism. Research Journal of Pharmaceutical Dosage Forms and Technology. 2023; 15(3): 211-4. doi: 10.52711/0975-4377.2023.00034
32. Singh, A., Chanda, D., and Negi, A. S. Antihypertensive activity of Diethyl-4, 4'-dihydroxy-8, 3'-neolign-7, 7'-dien-9, 9'-dionate through increase in intracellular cGMP level and blockade of calcium channels (VDCC) and opening of potassium channel and in vivo models (SHRs and L-NAME induced hypertension). In Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018 (The 18th World Congress of Basic and Clinical Pharmacology) (pp. PO1-2). Japanese Pharmacological Society. 2018.
33. Tim F. Dorweiler, Arjun Singh, Richard N Kolesnick, Julia V. Busik; Inhibition of ceramide rich platforms by anti-ceramide immunotherapy prevents retinal endothelial cell damage and the development of diabetic retinopathy. Invest. Ophthalmol. Vis. Sci. 2023; 64(8): 941.
34. Sirisha. Recent Advacements on Colon Targeted Drug Delivery Systems. Asian J. Pharm. Res. 2020; 10(4): 268-274.
35. Sampoornam W. Nurse Researcher’s Role in Breast Cancer Biomarkers. Int. J. Adv. Nur. Management. 2014; 2(1): 46-47.
36. U. D. Shivhare. Effect of Combination of Hydrophilic and Hydrophobic Polymers on Transdermal Drug Delivery Systems Properties. Research J. Pharma. Dosage Forms and Tech. 2011; 3(5): 203-209.