Author(s): Muhammad Hamza Ashfaq


DOI: 10.52711/2231-5691.2023.00034   

Address: Muhammad Hamza Ashfaq
Department of Chemistry, School of Science, University of Management and Technology, Lahore, Pakistan.
*Corresponding Author

Published In:   Volume - 13,      Issue - 3,     Year - 2023

In a present review article, relationships were identified between the structure and activity of the bis-thiosemicarbazone ligands and their zinc and copper complexes. These compounds have different substituents at the diimine point and terminal nitrogen of the backbone. All the copper complexes showed distortion in geometry from square planar while all the zinc complexes showed distortion in geometry from square pyramidal. In electrochemistry determination by cyclic voltammetry, all the copper complexes were found quasi-reversible. When the antiproliferative activity was checked against tumor cells, copper complexes showed the greatest activity. It was seen that antiproliferative activity was decreased when hydrophobic moieties were present at diimine points and terminal nitrogen. Zinc complexes showed the lowest antiproliferative activity because they were failed in ligand delivery intracellularly as they were not chaperone. But cobalt showed good activity by successfully delivering the ligand acting as chaperone1. Copper complexes showed more antiproliferative activity as compared to the ligand. In the environment of the tumor, hypoxia was found which decreased the antiproliferative activity of the ligand and its copper complexes. In the present study, it was concluded that this relationship could be helpful in the synthesis of antitumor agents such as bis-thiosemicarbazone and its complexes.

Cite this article:
Muhammad Hamza Ashfaq. Synthesis and Anticancer Activity of Bis-Thiosemicarbazone Complexes. Asian Journal of Pharmaceutical Research. 2023; 13(3):181-5. doi: 10.52711/2231-5691.2023.00034

Muhammad Hamza Ashfaq. Synthesis and Anticancer Activity of Bis-Thiosemicarbazone Complexes. Asian Journal of Pharmaceutical Research. 2023; 13(3):181-5. doi: 10.52711/2231-5691.2023.00034   Available on:

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Author(s): Muhammad Hamza Ashfaq

DOI: 10.52711/2231-5691.2023.00034         Access: Closed Access Read More

Asian Journal of Pharmaceutical Research (AJPRes.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. AJPRes. publishes Original Research Articles, Short Communications..... Read more >>>

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