Author(s):
Ibukun O. Adeleke, Ignatius S. Okafor
Email(s):
ibukun.adeleke@iuokada.edu.ng
DOI:
10.52711/2231-5691.2025.00037 
Address:
Ibukun O. Adeleke1*, Ignatius S. Okafor2
1Department of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, Igbinedion University Okada, Nigeria.
2Department of Pharmaceutical Technology and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, University of Jos, Jos, Nigeria.
*Corresponding Author
Published In:
Volume - 15,
Issue - 3,
Year - 2025
ABSTRACT:
The shortcomings of existing excipients such as low dilution potential and poor die filling as a result of poor flow properties have been a problem in direct compression tableting. The objective of this study was to formulate and evaluate the flow properties of co-processed Caesalpinia gum and annealed maize starch at various ratios as a potential direct compression excipient. Caesalpinia gum was extracted from the fresh seeds of Caesalpinia pulcherrima plant (Family Caesalpiniaceae). The gum was co-processed with the annealed maize starch at varying ratios in a co-solvent system consisting of acetone and distilled water (2:1). The flow properties of the co-processed excipients were determined using standard methods such as bulk density, tapped density, particle density, angle of repose, Hausner ratio, and Carr’s index. Cellactose was used as a standard for comparison. It was found out that Batch III (15:85) Caesalpinia gum: annealed maize starch gave the best flow among the batches of the co-processed excipients containing Caesalpinia gum and annealed maize with angle of repose of 31.48°±0.74, bulk, tapped, particle density of 0.42±0.06 g/cm3, 0.49±0.12 g/cm3, and 1.56±0.07 g/cm3 respectively, Carr’s index of 15.79 %, and Hausner ratio of 1.19. The study confirmed that the co-processed excipient flowed well in comparison with Cellactose® 80 in flowability properties which was used as a standard for comparison, and can be used as a substitute for the commercially available co-processed excipient Cellactose® 80.
Cite this article:
Ibukun O. Adeleke, Ignatius S. Okafor. Formulation and evaluation of flow properties of co-processed Caesalpinia gum and annealed maize starch. Asian Journal of Pharmaceutical Research. 2025; 15(3): 229-233. doi: 10.52711/2231-5691.2025.00037
Cite(Electronic):
Ibukun O. Adeleke, Ignatius S. Okafor. Formulation and evaluation of flow properties of co-processed Caesalpinia gum and annealed maize starch. Asian Journal of Pharmaceutical Research. 2025; 15(3): 229-233. doi: 10.52711/2231-5691.2025.00037 Available on: https://asianjpr.com/AbstractView.aspx?PID=2025-15-3-19