Author(s): Audumbar Mali, Sujata Kolekar, Jija Franklin, Ritesh Bathe

Email(s): maliaudu442@gmail.com

DOI: 10.5958/2231-5691.2016.00002.2   

Address: Audumbar Mali1*, Sujata Kolekar2, Jija Franklin2, Ritesh Bathe1
1Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, India.
2Department of Quality Assurance, Shri D.D. Vispute college of Pharmacy and Research Centre, Devad-Vichumbe, New Panvel, Raigad-410206, Maharashtra, India.
*Corresponding Author

Published In:   Volume - 6,      Issue - 1,     Year - 2016


ABSTRACT:
Two simple, precise, economical, fast and reliable UV methods have been developed for the simultaneous estimation of Ranitidine and Domperidone in bulk and pharmaceutical dosage form. Method A is Absorbance maxima method, which is based on measurement of absorption at maximum wavelength of 314 nm and 286 nm for Ranitidine and Domperidone respectively. Method B is area under curve (AUC), in the wavelength range of 269-340 nm for Ranitidine and262-307nm for Domperidone. Linearity for detector response was observed in the concentration range of 5-25µg/ml for Ranitidine and 5-25 µg/ml for Domperidone. The accuracy of the methods was assessed by recovery studies and was found to be 99.18 % and 100.21 % for Ranitidine and 100.19 % and 101.57 % Domperidone by using method A and B respectively. The developed method was validated with respect to linearity, accuracy (recovery), precision and specificity. The results were validated statistically as per ICH Q2 R1guideline and were found to be satisfactory. The proposed methods were successfully applied for the determination of for Ranitidine and Domperidone in commercial pharmaceutical dosage form.


Cite this article:
Audumbar Mali, Sujata Kolekar, Jija Franklin, Ritesh Bathe. Simultaneous UV Spectrophotometric Methods for Estimation of Ranitidine and Domperidonein Bulk and Tablet Dosage Form. Asian J. Pharm. Res. 6(1): January -March, 2016; Page 05-10. doi: 10.5958/2231-5691.2016.00002.2


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DOI: 10.5958/2231–5691 


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