Author(s): Kamma Keerthi Sai

Email(s): marzinaaj@gmail.com

DOI: 10.52711/2231-5691.2024.00032   

Address: Kamma Keerthi Sai*
Assistant Professor, Department of Pharmaceutics, Aditya College of Pharmacy, Aditya Nagar, ADB Road, Surampalem, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 3,     Year - 2024


ABSTRACT:
The aim of the present study is Formulation and Evaluation of Phenytoin by making solid dispersion with polyvinyl alcohol and inclusion complexation with HPß Cyclodextrin, ß Cyclodextrin. Solid dispersion of Phenytoin is prepared with Solvent Evaporation method. Phenytoin belongs to BCS class II drug which is characterized by high membrane permeability, slow dissolution rate due to low aqueous solubility. It is an anti-epileptic or anti- convulsant is used to treat wide variety of Seizures. The Phenytoin solid dispersions were prepared by solvent evaporation method at 1:0.25, 1:0.5, 1:0.75, 1:1, 1:1.25, 1:1.5 ratios of Phenytoin to HP ß CD, ß CD and PVA. The prepared dispersions were evaluated by solubility studies, in-vitro dissolution studies, melting point determination, drug content uniformity, entrapment efficiency and FT-IR studies. Finally comparing all the formulations (P:HPß F1-P:HPß F6) (P: ßF1-P ßF6) and (P:PF1-P:PF6) formulation P:PF4 containing Phenytoin: Polyvinyl alcohol (1:1) shows better result at the end of 90 min with drug release 93.99%, hence it was selected as the best formulation. By release kinetic studies of best formulation of Phenytoin with zero order and first order we can say that the best formulation follows first order kinetics studies having r2 value 0.945 where as zero order release kinetics studies having r2 value 0.849. The results indicated as formulated solid dispersion tablets displayed better dissolution profiles as compared to existing commercial tablets.


Cite this article:
Kamma Keerthi Sai. Formulation and Evaluation of Solid Dispersion of Phenytoin by Solvent Evaporation Technique. Asian Journal of Pharmaceutical Research. 2024; 14(3):199-5. doi: 10.52711/2231-5691.2024.00032

Cite(Electronic):
Kamma Keerthi Sai. Formulation and Evaluation of Solid Dispersion of Phenytoin by Solvent Evaporation Technique. Asian Journal of Pharmaceutical Research. 2024; 14(3):199-5. doi: 10.52711/2231-5691.2024.00032   Available on: https://asianjpr.com/AbstractView.aspx?PID=2024-14-3-1


REFERENCES:
1.    Kuchekar B.S and Yadav A.V. Studies on solid dispersion of Paracetamol. The Eastern Pharmacist., 1995; 38: 149.
2.    10. Hoerter D., and Dressman J.B. Influence of physico chemical properties on dissolution of drugs in the gastrointestinal tract. Adv.Drug Delivery Rev. 1997; 25-14.
3.    1.Ajay Kumar shukla, Ram singh B., Suresh Kumar dev, Vikas Fenin, Manish Kumar. Biopharmaceutical classification system tool-based predicting for drug dosage formulation. 2017; 2(6): 204-209.
4.    Kataria Mahesh Kumar et al. Bandar Anil. The Biopharmaceutics drug disposition classification system, an extension of Biopharmaceutical classification system. 2012; 3(3).
5.    Loftsson T. and Brewster M.E. Pharmaceutical applications of Cyclodextrins, Drug solubilization and stabilization. J. pharm. Sci, 1996; 85: 1010-1025.
6.    Modi A., and Prahalad T. Enhancement of dissolution profile by solid dispersion (kneading) technique. AAPS, Pharm Sci Tech., 2006; 129-132.
7.    Barillarov et al. Study of Phenytoin solid dispersions: formulation using automated solvent casting method, dissolution testing and scaling-up. 2008; 10(5): 637-643.
8.    Patel karan et al., Solubility enhancement of Phenytoin by solid dispersion technique and its comparison with Inclusion complexation, The International Journal of Pharmaceutical Research and Bio-Science. 2013.

Recomonded Articles:

Author(s): Habeeb Ahmed, Mohammed Ehtesham, Nuha Rasheed , Abdul Saleem Mohammad

DOI: 10.5958/2231-5691.2017.00006.5         Access: Open Access Read More

Author(s): R. R. Shah, S. A. Mohite, N. R. Patel

DOI: 10.5958/2231-5691.2018.00007.2         Access: Open Access Read More

Author(s): Ravi Kumar, Komal

DOI: 10.5958/2231-5691.2021.00003.4         Access: Open Access Read More

Author(s): Ashok Thulluru, Nawaz Mahammed, C. Madhavi, K. Nandini, S. Sirisha, D. Spandana

DOI: 10.5958/2231-5691.2019.00016.9         Access: Open Access Read More

Author(s): Hiral A. Makadia, Ami Y. Bhatt, Ramesh B. Parmar, Ms. Jalpa S. Paun, H.M. Tank

DOI:         Access: Open Access Read More

Author(s): Kaustubh V. Gavali, Manohar D. Kengar, Kiran V. Chavan, Vaishnavi P. Anekar, Naziya I. Khan

DOI: 10.5958/2231-5691.2019.00020.0         Access: Open Access Read More

Author(s): Mr. Paresh A Patil, Mr. Vitthal. V. Bhosale, Ms. Varsha. P. Girase

DOI: 10.5958/2231-5691.2020.00023.4         Access: Open Access Read More

Author(s): Prajapati M., Mandloi R., Pillai S, Birla N.

DOI: 10.5958/2231-5691.2020.00021.0         Access: Open Access Read More

Author(s): B.A. Bhairav, J.K. Bachhav, R.B. Saudagar

DOI: 10.5958/2231-5691.2016.00025.3         Access: Open Access Read More

Author(s): Rutuja R. Shah, Rohan R. Vakhariya

DOI: 10.5958/2231-5691.2020.00003.9         Access: Open Access Read More

Author(s): Sarika V. Khandbahale

DOI: 10.5958/2231-5691.2019.00021.2         Access: Open Access Read More

Author(s): Rutuja S. Shah, Rutuja R. Shah, Manoj M. Nitalikar, Chandrakant S. Magdum

DOI: 10.5958/2231-5691.2017.00024.7         Access: Open Access Read More

Author(s): Ghanshyam Dhalendra, Trilochan Satapathy, Amit Roy

DOI:         Access: Open Access Read More

Author(s): S.K. Purohit, R. Solanki, V. Mathur, M. Mathur

DOI:         Access: Open Access Read More

Author(s): Rina G. Maskare, Ayush P. Agrawal, Mayuri S. Pal, Jidnyasa R. Yerne, Megham Chaudhri, Anup R. Bawankar, Gaytri B. Sonkusre

DOI: 10.52711/2231-5691.2022.00025         Access: Open Access Read More

Author(s): Mercy Mathew, Ravikumar, Simila Madathil, Anju Govind, Narayana Swamy VB

DOI: 10.5958/2231-5691.2016.00015.0         Access: Open Access Read More

Author(s): Rutuja S. Shah, Rutuja R. Shah, Manoj M. Nitalikar, Chandrakant S. Magdum

DOI: 10.5958/2231-5691.2017.00028.4         Access: Open Access Read More

Author(s): Snehal B. Kulkarni, M. M. Bari,S. D. Barhate, Ashutosh Tripath

DOI: 10.5958/2231-5691.2019.00003.0         Access: Open Access Read More

Author(s): Priyanka Kusarkar, Mayuri Kupkar, Trupti Dudhgaonkar

DOI: 10.52711/2231-5691.2022.00032         Access: Open Access Read More


Recent Articles




Tags