Asian Journal of Pharmaceutical Research

ISSN

2231-5691 (Online)
2231-5683 (Print)


Submit Article

Analysis of the central and peripheral mechanisms underlying the analgesic effects of the extracts of Phyllanthus amarus and Phyllanthus fraternus

Author(s): Atul R. Chopade, F. J. Sayyad

Email(s): chopadearv@gmail.com

DOI: Not Available

Address: Atul R. Chopade* and F. J. Sayyad
Dept. of Pharmacology and Pharmacognosy, Government College of Pharmacy, Karad, Dist. Satara. 415124.
*Corresponding Author

Published In:   Volume - 3,      Issue - 1,     Year - 2013

 View HTML        View PDF

ABSTRACT:
Ethnopharmacological relevance: A great number of preclinical and clinical studies have not only confirmed but have also extended the medicinal uses of species of the genus Phyllanthus mentioned in traditional medicine. Aim of the study: To evaluate the central and peripheral mechanisms underlying the analgesic effects of the extracts of Phyllanthus amarus and Phyllanthus fraternus in mice using the acetic acid-induced writhing and hot plate tests. Materials and methods: a) Writhing was induced by intraperitoneal injection of 0.6% acetic acid (v/v) (80 mg/kg body wt.) and the number of muscular contractions were counted for 30 min following acetic acid injection with animals treated with the extracts of Phyllanthus amarus and Phyllanthus fraternus. b) The assay was performed according to the classical hot-plate technique of Eddy and Leimbach. The parameter evaluated was the latency time for paw licking and jumping responses after exposure to the hot plate surface. Results: Results showed that the extracts of Phyllanthus amarus and Phyllanthus fraternus given intraperitoneally can significantly attenuate acetic acid-induced writhing in mice in a dose-dependent manner. In the hot plate latency test, Phyllanthus extracts showed common activity in prolonging duration time and caused marked inhibition of acetic acid induced pain. Conclusions: These findings of the current study imply the involvement of both peripheral and central antinociceptive mechanisms.


Keywords:

Cite this article:
Atul R. Chopade, F. J. Sayyad. Analysis of the central and peripheral mechanisms underlying the analgesic effects of the extracts of Phyllanthus amarus and Phyllanthus fraternus. Asian J. Pharm. Res. 3(1): Jan.-Mar. 2013; Page 10-14.

Cite(Electronic):
Atul R. Chopade, F. J. Sayyad. Analysis of the central and peripheral mechanisms underlying the analgesic effects of the extracts of Phyllanthus amarus and Phyllanthus fraternus. Asian J. Pharm. Res. 3(1): Jan.-Mar. 2013; Page 10-14.   Available on: https://asianjpr.com/AbstractView.aspx?PID=2013-3-1-4


Recomonded Articles:

Effects of Anti-Inflammatory Activity of Mimosa pudica.

Author(s): Venkateshwarlu Goli, Kanakam Vijay Bhaskar, Sravan Prasad Macharla, Jimmidi.Bhaskar, P. Suvarna Devi, T. Ramchander

DOI:         Access: Open Access Read More

Pharmacological Evaluation of Trichilia connaroides Bark for Analgesic and Anti-inflammatory activity in Experimental Animal Models

Author(s): Muhammed Shakkeel K.V, Anjan Kumar, Veeresh Babu. D, Narayana Swamy V.B

DOI: 10.5958/2231-5691.2015.00021.0         Access: Open Access Read More

Anti-Asthmatic, Analgesic and Anti-Convulsant activities of the medicinal plant Bryonia laciniosa. Linn. Contributors

Author(s): Raafia Aseena, Syeda Zeba Hyder Zaidi, Nuha Rasheed, Abdul Saleem Mohammad

DOI: 10.5958/2231-5691.2017.00040.5         Access: Open Access Read More

Synthesis, Characterization, Anti Microbial, Analgesic activities of 3-(3-Chlorophenyl)-5-Phenyl-4,5-Dihydro-1,2-Oxazole Derivatives

Author(s): V Jhansipriya Marabathuni, K. Mariyamma, K. Sravani, S. Ramaiah, P. Ravindra, R. Srihari

DOI: 10.5958/2231-5691.2017.00026.0         Access: Open Access Read More

An Aqueous Extract of the Leaves of Chromolaena odorata Moderated Plasma Biochemical and Hematological Indices of Sub-Chronic Salt-Loaded Rats

Author(s): Jude Chigozie Ikewuchi, Catherine Chidinma Ikewuchi and Mercy Onuekwuzu Ifeanacho

DOI:         Access: Open Access Read More

Antidepressant, Analgesic Activity and SAR Studies of Substituted Benzimidazoles

Author(s): Nadeem Siddiqui, Md Shamsher Alam, Meeta Sahu, M. Shahar Yar, Ozair Alam, Mohammad Jamshed Ahmad Siddiqui

DOI:         Access: Open Access Read More

Microwave-Assisted Synthesis, Characterization and Biological Activity of Novel Pyrazole Derivatives

Author(s): T. Panneer Selvam, G. Saravanan, C. R. Prakash, P. Dinesh Kumar

DOI:         Access: Open Access Read More

Moderation of the Plasma Chemistry and Hematological Indices of Normal and Salt-loaded Rats by an Aqueous Extract of the Rhizomes of Sansevieria Liberica: Implications for the Management of Hypertension and Associated Complications

Author(s): Ikewuchi Jude C.1*, Ikewuchi Catherine C.1, Ifeanacho Mercy O.1, Igboh Ngozi M.2, Enuneku Emeke C.1 and Osayande Osazee I.1

DOI:         Access: Open Access Read More

Analgesic activity and anti-inflammatory activity of methanolic extract of plant Sida cordata in carrageenan-induced paw edema in rats

Author(s): Prajakta P Shinde, Shahu D Khule, Sneha Sonawane, Suvarna Shelke

DOI: 10.52711/2231-5691.2021.00027         Access: Open Access Read More

Synthesis of Novel Thiazole Derivatives as Analgesic Agents

Author(s): G. Saravanan, V. Alagarsamy, C.R. Prakash, P. Dinesh Kumar, T. Panneer Selvam

DOI:         Access: Open Access Read More

Analysis of the central and peripheral mechanisms underlying the analgesic effects of the extracts of Phyllanthus amarus and Phyllanthus fraternus

Author(s): Atul R. Chopade, F. J. Sayyad

DOI:         Access: Open Access Read More

Evaluation of Analgesic potential of Cyathocline lyrata cass Plant in Rats by using Tail Flick and Hot Plate Method

Author(s): K.G. Malviya, U.D. Shivhare, Preeti Srivastav, S.C. Shivhare

DOI:         Access: Open Access Read More

Analgesic activity of Hydroalcholic extract of Achyranthes aspera leaves on animal model

Author(s): Karunakar Shukla, Sourabh Jain, Narendra Patil, Ketan Patil, Kalpesh Wagh

DOI: 10.52711/2231-5691.2021.00041         Access: Open Access Read More

Central Nervous System Depressant Activity of Aqueous Extract of Leaves of Azadirachta indica Linn in Mice

Author(s): P. Thamarai Selvi, M. Senthil Kumar, T. Yaswanth, E. Adiyaman, P.T. Anusha

DOI:         Access: Open Access Read More

Geomorphology, Phytochemistry, Ethnomedical and Pharmacological activities of Amaranthus viridis Linn.

Author(s): Pooja RC, Ajay B V, Bharathi DR

DOI: 10.52711/2231-5691.2023.00007         Access: Open Access Read More

In vivo Analgesics and in vitro Antioxidants Activity of Newly Synthesized Mannich Bases of Lawsone

Author(s): Gulam Muheyuddeen, Sarwar Husain Rayini, Priyanka Yadav, Sujeet Kumar Gupta

DOI: 10.52711/2231-5691.2023.00002         Access: Open Access Read More

An Overview on Emulgel

Author(s): Ashima Chandel, Neha Kumari, Rajesh Gupta, Aamir Nazir, Honey, Abi C. Varghese

DOI: 10.52711/2231-5691.2023.00037         Access: Open Access Read More

Comparison of Antifungal and Antimicrobial activities in different parts of Carica papaya Linn

Author(s): Wajid Azam, Vicky Rai, Rehan Jawed, Kalyani Jaywardhane, Vishal Thakur, Vishal Jain, Parwez Alam

DOI: 10.52711/2231-5691.2023.00040         Access: Open Access Read More

Asian Journal of Pharmaceutical Research (AJPRes.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. AJPRes. publishes Original Research Articles, Short Communications..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231–5691 

Quick Links


Latest Issues

Popular Articles


Recent Articles



A Case Study on Homeopathic Management of Psoriasis: An Alternative Treatment Approach
Nanomedicines for Infectious Disease: Potential Nanocarriers
Aspiration Pneumonia: An Updated Review on Risk Factors, Diagnosis, and Management
From Bench to Bedside: AI-Enabled Drug Repurposing for Innovative Therapies in Complex Diseases
A Review on Giant Calotropis Linn-Indian Traditional Medicine
Robotics and Pharmacy Automation: Enhancing efficiency safety and patient care
A Comprehensive Review on Transdermal Systems for Enhanced Wound Healing
Estimation of Tadalafil in Tablet Dosage form by UV Spectrophotometric Method
Groundwater Quality Assessment for Safe Drinking in Bareilly City
Development and Validation of Liquid Chromatography Tandem Mass Spectrometry Method for Baloxavir Estimation in human plasma
Design and Development of Ayurvedic Topical Formulation for the Management of Dyspepsia in Infant
Study of The effect of L-Riboce-D-Cystein on X-Ray-Induced Testiculur Damage in Adult Wistar Rats
A Review: The Pharmacological activities of Carica papaya
Hyponatremia in Depression: A Review
Animal Models of Alcoholic Liver Disease and Non-Alcoholic Fatty Liver Disease
Formulation and Evaluation of Metronidazole Effervescent Granules
A Wide Application of Artificial Intelligence in Pharma Field
Exploring the benefits of Chandraprbha Vati a Herbmineral Formulation
Computational Approaches in Targeting Monkeypox Virus: A Focus on Phytochemical Inhibition of Profilin-like Protein A42R
Synthesis and In vitro anticancer activity of some novel substituted carbazole carbamate derivatives against human glioma U87MG cell line

Tags


About Journal

Asian Journal of Pharmaceutical Research (AJPRes.) (ISSN: Print-2231–5683, Online-2231–5691) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. AJPRes. publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences .

The journal is published quarterly every year in last week of March, June, September and December from Raipur, India.    
Read More  

Visitors

Today: 787
Yesterday: 1432
Total: 1653157