Author(s):
Madhuri Deshmukh, Saurav Chavan, Tejeswini Deshmukh, Vikramsinh Deshmukh
Email(s):
madhuripharmacist9@gmail.com , sauravchavan721@gmail.com , tejeswini.deshmukhsvpm@gmail.com , vikramsinh.deshmukh@yahoo.com
DOI:
10.52711/2231-5691.2025.00038 
Address:
Madhuri Deshmukh1, Saurav Chavan2, Tejeswini Deshmukh3, Vikramsinh Deshmukh4
1,2S.K.N.C.O.P. Kondhwa BK PUNE.
3Shivnagar Vidya Prasarak Mandals, College of Pharmacy, Malegaon, Baramati.
4P.E. S’s College of Pharmacy and Research Center, Phaltan.
*Corresponding Author
Published In:
Volume - 15,
Issue - 3,
Year - 2025
ABSTRACT:
Objective:
Current study aimed to design Mebendazole loaded microsponges using Eudragit S100 polymer for colon targeting. Mebendazole drug commonly used for different worm infections. Mebendazole microsponges were made utilizing the quasi-emulsion solvent diffusion process and the Eudragit S100 Prepared microsponges Mebendazole were evaluated to different evaluation parameter like FTIR, particle size, entrapment capacity, drug release study and kinetics study. Optimized Mebendazole formulation having highest entrapment capacity (88.26%) and the mean particle size 27.37, showed spongy, spherical and uniform shape. Drug-polymer interactions study confirmed by FTIR and crystallinity issues by X-ray diffraction studies. The release pattern of the optimized batch followed the Korsmeyer-Peppas model. Stability study of optimized batch was within permissible limits. Present work suggests that Mebendazole-loaded microsponges were prepared using Eudragit S100 polymer for colon targeting to increase bioavailability and reduce side effects.
Cite this article:
Madhuri Deshmukh, Saurav Chavan, Tejeswini Deshmukh, Vikramsinh Deshmukh. Formulation and Evaluation of Mebendazole Loaded Microsponge for Colon Targeting. Asian Journal of Pharmaceutical Research. 2025; 15(3):234-0. doi: 10.52711/2231-5691.2025.00038
Cite(Electronic):
Madhuri Deshmukh, Saurav Chavan, Tejeswini Deshmukh, Vikramsinh Deshmukh. Formulation and Evaluation of Mebendazole Loaded Microsponge for Colon Targeting. Asian Journal of Pharmaceutical Research. 2025; 15(3):234-0. doi: 10.52711/2231-5691.2025.00038 Available on: https://asianjpr.com/AbstractView.aspx?PID=2025-15-3-2
REFERENCES:
1. Desta A., Anteneh B. and Nisha J.: Formulation, Optimization and In Vitro Evaluation of Solubility Enhanced Fast Disintegrating Tablets of Mebendazole, J Bioequiv Available an open access Journal. 2018: 10(4): 78-83.
2. Braithwaite PA., Roberts MS., Allan RJ. and Watson TR. Clinical pharmacokinetics of high dose mebendazole in patients treated for cystic hydatid disease. Eur J Clin Pharmacol. 1982; 22(2): 161-169.
3. Manisha K. and Pawar A.: Microsponges: A novel strategy for Drug delivery, International Journal of Pure and Applied Biosciences. 2015; 3(1): 224-235
4. Pavani V., Vinod M. and Anantha, P.).: Design, Formulation And In Vitro Evaluation of Microsponges Based Gel for Topical Delivery of Ketoconazole, International Journal of Pharmaceutical Sciences and Research. 2017; 8(10): 4222–4229
5. Pratap Singh R. and Kumar Prajapati S. Formulation And Evaluation of Prednisolone Loaded Microsponges for Colon Drug Delivery: In-Vitro and Pharmacokinetic Study, International Journal of Pharmaceutical Sciences and Research. 2014; 5(5).
6. Zaman M., Qureshi S., Sultana K., Hanif M., Mahmood A., Shaheryar Z. A., Gulzar F., Barkat K. and Abdel-Daim M. M. Application of quasi-emulsification and modified double emulsification techniques for formulation of tacrolimus microsponges, International Journal of Nanomedicine. 2018; 13: 4537–4548.
7. Karmakar S., Poddar S., Khanam J. Understanding the effects of associated factors in the development of microsponge-based drug delivery: a statistical quality by design (QbD) approach towards optimization, AAPS PharmSciTech. 2022; 23(7): 256.
8. Maskare R., Thakre S., Jaiswal A., Chawade, D., Vishwakarma S., Bahekar T. Formulation of Microsponge of Thyme for Acne Treatment. Res. J. Pharm. and Tech. 2013; 16(8): 3767-3772.
9. Sultan F, Chopra H., Sharma G. Formulation and Evaluation of Luliconazole Microsponges Loaded Gel for Topical Delivery. Res. J. Pharm. and Tech. 2021; 14(11): 5775-5780.
10. Rajurkar VG. Topical Anti-Inflammatory Gels of Naproxen Entrapped in Eudragit Based Microsponge Delivery System. J Adv Chem Eng. 2015 Jul 01; 5:1-6.
11. Bhatia M., Saini M. Formulation and evaluation of curcumin microsponges for oral and topical drug delivery. Prog Biomater. 2018; 7(3): 239-248. doi: 10.1007/s40204-018-0099-9.
12. Fatema K., Sajeeb B., Sikdar K.M., Yasif H., Monjur Al. and Bachar S. Evaluation of the Formulation of Combined Dosage Form of Albendazole and Mebendazole through In vitro Physicochemical and Anthelmintic Study. Dhaka University Journal of Pharmaceutical Sciences. 2022; 20: 153-163. 10.3329/dujps. v21i2.63116.
13. Swanepoel E., Liebenberg W., Devarakonda B. and De Villiers M. Developing a discriminating dissolution test for three mebendazole polymorphs based on solubility differences. Die Pharmazie. 2003; 58: 117-21.
14. Shrivastava S. and Kaur C. Fabrication of Mebendazole-loaded solid lipid nanoparticles: Formulation, optimization, characterization, stabilization, and in-vitro evaluation. International Journal of Pharmaceutical Sciences and Drug Research. 2022; 14: 262-268. 10.25004/IJPSDR.2022.140217.
15. United States Pharmacopoeia, 30th edition NF 25-2007. The Official Compendia of Standards. 643, Pharmacopoeial forum 32(1): 141.
16. Baviskar D., Rajput A., Bare K., Biranwar Y., Chaudhari H., Narkhede D., Jain D. Development and in vitro characterization of mebendazole delayed release tablet for colonic drug delivery, Pakistan Journal of Pharmaceutical Sciences. 2014; 27(2):249-53.
17. Dheeraj B., Amarjit R., Kapil B., Yogeshkumar B., Hiralal C., Deepak N., Dinesh J. Development and in-vitro characterization of mebendazole delayed release tablet for colonic drug delivery. Pak J. Pharm. Sci. 2014; 27(2): 249-253.
18. Dash S., Murthy PN., Nath L., Chowdhary P. Kinetic modeling on drug release from controlled drug delivery systems. Acta Pol Pharm. 2010; 67(3): 217-23.
19. Bagul US., Nazirkar MV., Mane AK., Khot SV., Tagalpallewar AA., Kokare CR. Fabrication of architectonic nanosponges for intraocular delivery of Brinzolamide: An insight into QbD driven optimization, in vitro characterization, and pharmacodynamics, International Journal of Pharmaceutics. 2024; 650:123746.
20. Rajurkar VG. Topical Anti-Inflammatory Gels of Naproxen Entrapped in Eudragit Based Microsponge Delivery System. J Adv Chem Eng. 2015; 5:1-6.
21. Fatema K., Sajeeb B., Sikdar K.M., Yasif H., Monjur Al. and Bachar S. Evaluation of the Formulation of Combined Dosage Form of Albendazole and Mebendazole through In vitro Physicochemical and Anthelmintic Study. Dhaka University Journal of Pharmaceutical Sciences. 2022; 20: 153-163.
22. Swanepoel E., Liebenberg W., Devarakonda B., De Villiers MM. Developing a discriminating dissolution test for three mebendazole polymorphs based on solubility differences. Die Pharmazie Int. J. of Pharma.Sci. 2003; 58(2): 117-21.
23. Lavhate K., SolunkeS., Kore K., Shete V., Deshmukh M. Development and Characterization of Mesalamine Microsphere for Colon Specific Drug Delivery. Res. J. Pharm. and Tech. 2020; 13(4): 1747-1751.
24. Ozdemir S., Uner B., Baranauskaite J., Sumer E., Yıldırım E., Yaba A. Design and characterization of dexamethasone loaded microsponges for the management of ulcerative colitis. Eur J. of Pharmaceutics and Biopharmaceutics. 2023; 187:34-45.
25. Kardile SS., Shendge RS., Salunke KS., Wagh OV. Colon-specific tablets containing naproxen microsponges for effective treatment of inflammatory bowel disease. International Journal of Health Sciences. 2022; III: 8419.
26. Nandhakumar S., Sugreevudu G., Harikrishnan N. Formulation design and Evaluation of Extended-Release Tablets of Oxybutynin for Effective Management of Overactive Bladder. Res. J. Pharm. and Tech. 2021; 14(12): 6558-6564.