Author(s):
Karunakar Shukla, Sourabh Jain, Narendra Patil, Ketan Patil, Kalpesh Wagh
Email(s):
pnarendra101@gmail.com
DOI:
10.52711/2231-5691.2021.00041
Address:
Dr. Karunakar Shukla1, Dr. Sourabh Jain1, Narendra Patil1*, Ketan Patil2, Kalpesh Wagh2
1Department of Pharmacology, Dr. A. P. J. Abdul Kalam University Indore, MP., India.
2Department of Phamaceuices, KVPS Institute of Pharmaceutical Education, Boradi, MS., India.
*Corresponding Author
Published In:
Volume - 11,
Issue - 4,
Year - 2021
ABSTRACT:
Achyranthes aspera L. (Family: Amaranthaceae) is widely used as a medicinal plant. The hydroalcholic extract of Achyranthes aspera L. leaves was screened for its analgesic activity. The dose (200 mg/kg) was tested for analgesic activity using hot plate and Tail flick test in albino mice. The hydroalcholic extract of Achyranthes aspera L. leaves showed maximum analgesic activity in hot plate at reaction time 120 min (7.40±0.08) and tail flick method at reaction time 120 min (6.9±0.06). These study suggest that the hydroalcholic extract of Achyranthes aspera L. could be considered as potential analgesic agent.
Cite this article:
Karunakar Shukla, Sourabh Jain, Narendra Patil, Ketan Patil, Kalpesh Wagh. Analgesic activity of Hydroalcholic extract of Achyranthes aspera leaves on animal model. Asian Journal of Pharmaceutical Research. 2021; 11(4):239-1. doi: 10.52711/2231-5691.2021.00041
Cite(Electronic):
Karunakar Shukla, Sourabh Jain, Narendra Patil, Ketan Patil, Kalpesh Wagh. Analgesic activity of Hydroalcholic extract of Achyranthes aspera leaves on animal model. Asian Journal of Pharmaceutical Research. 2021; 11(4):239-1. doi: 10.52711/2231-5691.2021.00041 Available on: https://asianjpr.com/AbstractView.aspx?PID=2021-11-4-3
REFERENCE:
1. Mehta F.A et.al.Antiociceptive and anti-inflammatory activity of Achyranthes aspera extracts. Pharmacologyonline. 2009; 3: 978-985. 2. Guyton, A.C., and Hall, J.E. Textbook of Medical Physiology. Philadelphia : Elsevier Saunders; 2006.
2. Singh, A., Malhotra, S., and Subban, R. Anti-inflammatory and analgesic agents from Indian medicinal plants. International Journal of Integrative Biology. 2008; 1: 57–72.
3. USDA-NRCS. The Plants Database. Baton Rouge. USA: National Plant Data Center.; 2012.
4. Aziz A, Rahman,et.al.. 3-Acetoxy-6-benzoyloxyapagamide from Achyranthes aspera. Journal of Pharmaceutical Sciences. 2005; 4(2): 113-116.
5. Umamaheswari M,et.al. Anticataract and antioxidant activities of Achyranthes aspera Linn. Against glucose-induced cataractogenesis using goat lenses. Journal of Natural Product and Plant Resources. 2012; 2: 153-161.
6. Varuna, KM, Khan MU and Sharma PK.Review on A. aspera. Journal of Pharmacy Research.2010; 3: 714-717.
7. Organisation for Economic co-operation and development ,Test no.423/acute oral toxicity-acute toxic class method in the OECD guideline for testing of chemicals OECD.Rome:2001.
8. Bhosale Uma et.al. Antinociceptive evaluation of an ethanol extract of Achyranthes aspera (agadha) in animal models of Nociception. International Journal of Phytomedicine. 2010; 2: 440-445.