Author(s): R. Revathi, T. Ethiraj, S. Anushiya, L. Narayanan, Jefrin Shine, J. Thamodharan

Email(s): revathethiraj@gmail.com

DOI: 10.52711/2231-5691.2024.00002   

Address: R. Revathi1*, T. Ethiraj2, S. Anushiya1, L. Narayanan1, Jefrin Shine1, J. Thamodharan1
1Department of Pharmaceutical Chemistry, Pannai College of Pharmacy, Mullipadi, Dindigul (Dt), Tamilnadu.
2Department of Pharmaceutics, Pannai College of Pharmacy, Mullipadi, Dindigul (Dt), Tamilnadu.
*Corresponding Author

Published In:   Volume - 14,      Issue - 1,     Year - 2024


ABSTRACT:
Cefpodoxime proxetil (CP) is an oral third generation cephalosporin antibiotic with effectiveness against most Gram positive and Gram negative bacteria. Commonly used to treat acute otitis media, pharyngitis, and sinusitis, CP is a prodrug which is absorbed and de-esterified by the intestinal mucosa to Cefpodoxime. Quality control evaluation of oral antibiotics has paramount importance to monitor the distribution of drugs in retail market and ensure the therapeutic efficacy against susceptible microorganism. The present work was performed to assess the quality control parameters of four brands of Cefpodoxime proxetil 200mg tablets available in Dindigul district. All the samples were analyzed for weight variation test, hardness, disintegration studies, percentage drug release by dissolution studies and percentage drug content determination by UV spectroscopic methods. The mean percentage drug content of Cefpodoxime proxetil varies from 93.9% w/w and 99.4% w/w among the products. The average hardness of the products varies from 5.5kg/cm2 to 9.33kg/cm2 respectively. All the brands had shown disintegration time 1.02 and 3.43 minutes while they showed 93.15% to 94.95% release of active ingredient within 30 minutes in dissolution studies. The present study revealed that all the brands of Cefpodoxime proxetil tablet met the quality control parameters as per pharmacopoeial specifications.


Cite this article:
R. Revathi, T. Ethiraj, S. Anushiya, L. Narayanan, Jefrin Shine, J. Thamodharan. Comparative Screening of In-vitro Quality Evaluation of different Brands of Cefpodoxime Proxetil Tablets. Asian Journal of Pharmaceutical Research. 2024; 14(1):10-4. doi: 10.52711/2231-5691.2024.00002

Cite(Electronic):
R. Revathi, T. Ethiraj, S. Anushiya, L. Narayanan, Jefrin Shine, J. Thamodharan. Comparative Screening of In-vitro Quality Evaluation of different Brands of Cefpodoxime Proxetil Tablets. Asian Journal of Pharmaceutical Research. 2024; 14(1):10-4. doi: 10.52711/2231-5691.2024.00002   Available on: https://asianjpr.com/AbstractView.aspx?PID=2024-14-1-2


REFERENCES:
1.    Devika GS, Devi S, Ramesh petchi R, Gokul C, Hari subha K, Robinson martin J, Isthiak ahamed K, Janani N, Deepa N. Development, and validation of UV-spectroscopic method for estimation of cefpodoxime proxetil in bulk and pharmaceutical dosage form. YMER. 2023; 22(2):57-64.
2.    Getu Kahsay1, Asfaw Debella, Kaleab Asres. Comparative in-vitro quality evaluation of ciprofloxacin tablets from drug retail outlets in Addis ababa. Ethiopia. Ethiop Pharm J. 2007; 25: 1-8.
3.    Mizanur Rahman M, Asraful Haque, Nahian Fyrose Fahim. Comparative quality evaluation of different brands of ciprofloxacin tablets available in pharmaceutical market of Bangladesh. Pharmacology Online. 2019; 1: 43-49.
4.    Md. Sahab Uddin, Abdullah Al Mamun, Md. Saddam Hossain, Md. Asaduzzaman, Md. Shahid Sarwar, Mamunur Rashid, Oscar Herrera Calderon. In vitro quality evaluation of leading brands of ciprofoxacin tablets available in Bangladesh. BMC Res Notes. 2017; 10(185): 1-9.
5.    Md. Sahab Uddin, Abdullah Al Mamun, Tanjuma Tasnu, Md. Asaduzzaman. In-process and finished products quality control tests for pharmaceutical tablets according to Pharmacopoeias. Journal of Chemical and Pharmaceutical Research. 2015; 7(9): 180-185.
6.    Kwabena Ofori-Kwakye, Frederic Osei-Yeboah, Samuel Lugrie Kipo. Formulation and quality evaluation of two conventional release tablet formulations. International Journal of Pharmaceutical Sciences Review and Research. 2010; 4(1): 94-99.
7.    Darshana R Dumbhare, Fahimuddin S Kazi, Debarshi Kar Mahapatra, Ujwala N Mahajan. Comparative quality analysis of cefpodoxime proxetil branded tablet product with available Indian generic products: Short-term accelerated study. International Journal of Current Research and Review. 2021; 13(7): 172 – 184.
8.    Athiya Nusrath, Deepika B, Nagaraju K, Regupathi T, Rao KNV, Rajeswar Dutt K. Formulation and in vitro evaluation of cefpodoxime proxetil gastro retentive floating tablets. Innovat International Journal of Medical & Pharmaceutical Sciences. 2017; 2(1): 1-7.
9.    Teja Dasari, Sai Lakshmi Jyothirmai Kala, Rama Rao Nadendla. In process quality control tests of solid dosage forms: a comprehensive review. Scholars Academic Journal of Pharmacy. 2017; 6(8): 334-345.
10.    Inder Kumar, Vinay Pandit. Cefpodoxime proxetil fast dissolving tablets: Comparative study. International Journal of Pharmacy and Pharmaceutical Science. 2020; 12(11): 35-41.
11.    Syed Shariff Miyan, Ramesh R, Vazir Ashfaq Ahamed. Formulation and evaluation of cefpodoxime proxetil matrix tablets by using different polymers. Research J. Pharm. and Tech. 2011; 4(7): 1060-1068.    
12.    Basava Raju D, Venkanna B, Sita Priya Darsini Y, Jaya Prakash V. Evaluation of Different Marketed Brands of Losartan PotassiumTablets: A Comparative Study with Generic Shop Products. International Journal of Research in Pharmacy and Science. 2020; 10(2): 27-39.
13.    Indian Pharmacopoeia, 7th Edition, Indian Pharmacopoeia Commission, Ghaziabad, 2014.
14.    United States Pharmacopoeia Convention. United States Pharmacopoeia 38-National Formulary 33, Stationery Office, USA, 2010.
15.    British Pharmacopoeia. 8th Edition. British Pharmacopoeia Commission. Great Britain: Stationery Office, 2014.
16.    Duraivel S, Venkateswarlu V, Ammula Praveen Kumar, Harish Gopinath. Enhancement of dissolution rate of cefpodoxime proxetil by using solid dispersion and cogrinding approaches. Research J. Pharm. and Tech. 2012; 5(12): 1552-1562.
17.    Fahim Khan, Rajesh Katara, Suman Ramteke. Enhancement of bioavailability of cefpodoxime proxetil using different polymeric microparticles. AAPS Pharm Sci Tech. 2010; 11(3): 1368-1375.
18.    Arora SC, Sharma PK, Raghuveer Irchhaiya, Anurag Khatkar, Neeraj Singh, Jagbir Gagoria. Development, characterization and solubility study of solid dispersion of cefpodoxime proxetil by solvent evaporation method. International Journal of Chem Tech Research. 2010; 2(2): 1156-1162.
19.     Kashish Aziz, Babar Iqbal, Azim Akhtar, Kanchan Kohli, Sanjula Baboota and Abdul Mateen. Formulation and Evaluation of Cefpodoxime Proxetil Solid Dispersion: An Approach for Dissolution Enhancement of Cephalosporin, Asian Journal of Pharmaceutical Technology & Innovation. 2015; 3(12): 121-126.
20.    Shruti Jaswal, Rajeev Garg. Enhancement of Cefpodoxime Proxetil Drug by Using Solid Dispersion Method and Polymer using Cyclodextrins. International Journal of Modern Pharmaceutical Research. 2020; 4(4): 66-88.
21.    Shalini Khatri, Kuldeep Gangawat, Seema Saini. Evaluation and Formulation of Immediate Release Tablet of Cefpodoxime Proxetil. International Journal of Universal Pharmacy and Bio Sciences. 2014; 3(3): 195-206.
22.    Auditi Kar , Mohammad Nurul Amin , Mohammad Salim Hossain, Md. Emdadul Hasan Mukul, Md. Saif Uddin Rashed, Md. Ibrahim. Quality analysis of different marketed brands of paracetamol available in Bangladesh. International Current Pharmaceutical Journal. 2015; 4(9): 432-435.
23.    Karmakar P, Kibria MG. In-vitro comparative evaluation of quality control parameters between paracetamol and paracetamol/caffeine tablets available in Bangladesh. International Current Pharmaceutical Journal. 2012; 1(5): 103-109.

Recomonded Articles:

Author(s): Habeeb Ahmed, Mohammed Ehtesham, Nuha Rasheed , Abdul Saleem Mohammad

DOI: 10.5958/2231-5691.2017.00006.5         Access: Open Access Read More

Author(s): Ashok Thulluru, Nawaz Mahammed, C. Madhavi, K. Nandini, S. Sirisha, D. Spandana

DOI: 10.5958/2231-5691.2019.00016.9         Access: Open Access Read More

Author(s): Rutuja S. Shah, Rutuja R. Shah, Manoj M. Nitalikar, Chandrakant S. Magdum

DOI: 10.5958/2231-5691.2017.00024.7         Access: Open Access Read More

Author(s): Snehal B. Kulkarni, M. M. Bari,S. D. Barhate, Ashutosh Tripath

DOI: 10.5958/2231-5691.2019.00003.0         Access: Open Access Read More

Author(s): Dasari Nirmala, Swapna Nandhini, M. Sudhakar

DOI: 10.5958/2231-5691.2016.00012.5         Access: Open Access Read More

Author(s): Mukul Ahmed, Ravikumar, Narayanaswamy VB, Injamamul Haque, Mohibul Hoque

DOI: 10.5958/2231-5691.2016.00020.4         Access: Open Access Read More

Author(s): Swapna. A. S, Vishnu M V, Irene V R, Meera T R, Farsana A, Melba Paulson, Joona E

DOI: 10.5958/2231-5691.2021.00002.2         Access: Open Access Read More

Author(s): K. Vijaya Sri, R. Harish Kumar Reddy , R. Mahesh

DOI:         Access: Open Access Read More

Author(s): Injamamul Haque, Ravikumar, Narayanaswamy VB, Mohibul Hoque

DOI: 10.5958/2231-5691.2016.00023.X         Access: Open Access Read More

Author(s): Girish Pai K., Vamshi Krishna T., Lalit Kumar, M. Sreenivasa Reddy, G. Shreenidhi, A. Praneeth Reddy

DOI:         Access: Open Access Read More

Author(s): Prakash Goudanavar, Doddayya Hiremath, Spandana D. , S. R. Reddy

DOI:         Access: Open Access Read More

Author(s): Sugiyartono, Tutiek Purwanti, Isnaeni, Dhenok Reso Fenda Asega

DOI:         Access: Open Access Read More

Author(s): Mamatha Kola, Subharna Mallik, Pranusha Palle, Pallavi Kamarapu

DOI:         Access: Open Access Read More

Author(s): Prathibha Suvarna, Ravi Kumar, Yamunappa, Pooja Shetty, Narayana Swamy V.B.

DOI: 10.5958/2231-5691.2016.00003.4         Access: Open Access Read More

Author(s): Partha Pratim Mahata, Abhimanyu Thakur, Kamalika Bhattacharya, Rakesh Kumar, Sunita Mondal, Wrijula Mukherjee, Anurup Mukhopadhyay

DOI: 10.5958/2231-5691.2015.00026.X         Access: Open Access Read More

Author(s): Mr. Bhushan P. Gayakwad, . Shashikant D. Barhate, Prafull P. Patil, . Mayur S. Jain

DOI: 10.5958/2231-5691.2018.00009.6         Access: Open Access Read More

Author(s): Nirmala Rangu, B. Chaitanya Kumari, Ganesh Akula, A Jaswanth

DOI: 10.5958/2231-5691.2018.00021.7         Access: Open Access Read More

Author(s): Ashok Thulluru, C. Madhavi, K. Nandini, S. Sirisha, D. Spandana

DOI: 10.5958/2231-5691.2019.00041.8         Access: Open Access Read More

Asian Journal of Pharmaceutical Research (AJPRes.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. AJPRes. publishes Original Research Articles, Short Communications..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231–5691 


Recent Articles




Tags