Ashwini P. Dhruv, Nilesh K. Patel, Ashok B. Patel, Amit Kumar J. Vyas, Ajay I. PatelAshwini P. Dhruv, Nilesh K. Patel, Ashok B. Patel, Amit Kumar J. Vyas, Ajay I. Patel
Ashwini P. Dhruv*, Nilesh K. Patel, Ashok B. Patel, Amit Kumar J. Vyas, Ajay I. Patel
Pharmaceutical Quality Assurance Department, B.K. Mody Government Pharmacy College,
Rajkot, Gujarat, India.
Volume - 12,
Issue - 3,
Year - 2022
The coronavirus disease 19(COVID-19) is a highly transmittable and pathogenic viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-II), which emerged in Wuhan, China and spread around the world. It is considered a relative of Severe Acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), The cause of COVID-19 is a beta coronavirus named SARS-CoV-2 that affects the lower respiratory tract and manifests as pneumonia in humans. The Asymptomatic carriers have become the current focus of global epidemic prevention and control efforts. These carriers of the virus display no clinical symptoms but are known to be contagious. As "silent spreaders", asymptomatic carriers warrant attention as a part of disease prevention and control. The comparable viral load in a group of asymptomatic carriers of COVID-19 was found to be higher than that of the symptomatic carriers. There are numerous micronutrients which are essential for immunocompetence, particularly Vitamin A, C, D, E, B, iron, selenium, and zinc. Immunonutrition refers to the modulation of the immune system through the modification of dietary nutrients. Vitamins A to E highlighted potentially beneficial roles in the fight against COVID-19 via antioxidant effects, immunomodulation, enhancing natural barriers, and local paracrine signaling. The present review provides a brief information on supplementation of Immunonutrients in form of vitamins which ultimately can act as prophylactic regimen for Asymptomatic carriers of SARS CoV-II virus.
Cite this article:
Ashwini P. Dhruv, Nilesh K. Patel, Ashok B. Patel, Amit Kumar J. Vyas, Ajay I. PatelAshwini P. Dhruv, Nilesh K. Patel, Ashok B. Patel, Amit Kumar J. Vyas, Ajay I. Patel. A Review on Prophylactic Regimen by Evaluation of Asymptomatic SARS CoV-II Carriers. Asian Journal of Pharmaceutical Research. 2022; 12(3):217-4. doi: 10.52711/2231-5691.2022.00036
Ashwini P. Dhruv, Nilesh K. Patel, Ashok B. Patel, Amit Kumar J. Vyas, Ajay I. PatelAshwini P. Dhruv, Nilesh K. Patel, Ashok B. Patel, Amit Kumar J. Vyas, Ajay I. Patel. A Review on Prophylactic Regimen by Evaluation of Asymptomatic SARS CoV-II Carriers. Asian Journal of Pharmaceutical Research. 2022; 12(3):217-4. doi: 10.52711/2231-5691.2022.00036 Available on: https://asianjpr.com/AbstractView.aspx?PID=2022-12-3-7
1 Badawi A, Ryoo SG. Prevalence of comorbidities in the Middle East respiratory syndrome coronavirus (MERS-CoV): A systematic review and meta-analysis. Int. J. Infect. Dis 2016; 49:129–133.
2 Vijayanand P, Wilkins ED, Woodhead M. Severe acute respiratory syndrome (SARS): A Review. Clin. Med 2004; 4(2): 152-160
3 Sharma A, Mohanan K. Obstacles Faced by Nurses working in Covid-19 Unit: A Developing Country view Point. Asian J. Nursing Education and Research. 2020; 10(4):459-62.
4 Fernanades M, Thakur JR, Gavanje MS. A study to assess knowledge regarding Covid-19 among nursing students. Asian Journal of Nursing Education and Research 2021; 11(1) :65-67.
5 Wang LF, Shi Z, Zhang S, Field H, Daszak P, Eaton BT. Review of bats and SARS. Emerg Infect. Dis. 2006;12(12): 1834-40.
6 JainMS, Barhate SD. Corona viruses are a family of viruses that range from the common cold to MERS corona virus: A Review. Asian J. Res. Pharm. Sci. 2020; 10(3):204-210
7 Kishor SR, Ramhari BM. Introduction to Covid-19. Research J. Science and Tech. 2020; 12(4):338-45.
8 Yadav AR, Mohite SK. A Review on Severe Acute Respiratory Infection (SARI) and its Clinical Management in Suspect/ Confirmed Novel Coronavirus (nCoV) Cases. Res. J. Pharma. Dosage Forms and Tech.2020; 12(3):178-180.
9 Naresh BV. A review of the 2019 Novel Coronavirus (COVID 19) Pandemic. Asian J. Pharm. Res. 2020; 10(3): 233-8.
10 Bergmann CC, Silverman RB. COVID-19: Coronavirus replication, pathogenesis, and therapeutic strategies. Cleveland Clinic Journal of Medicine 2020; 87(6): 321-7.
11 Pan X, Chen D, Xia Y, et al. Asymptomatic cases in a family cluster with SARS-CoV-2 infection. Lancet Infect. Dis. 2020; 20(4): 410-11
12 Bai Y, Yao L, Wei T, et al. Presumed asymptomatic carrier transmission of COVID-19. JAMA 2020: 323(14) :1406-7
13 Guan W, Ni Z, Hu Y, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N. Engl. J. Med. 2020; 382: 1708-20
14 Wang W, Tang J, Wei F. Updated understanding of the outbreak of 2019 novel coronavirus (2019-nCoV) in Wuhan. China J Med Virol 2020; 92: 441–447
15 Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet 2020; 395: 495-506.
16 Lei. J, Li J, Li X, et al. CT imaging of the 2019 novel coronavirus (2019-nCoV) pneumonia. Radiology 2020; 295: 200-236.
17 Wiersinga WJ, Rhodes A, Cheng AC, et al. Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19) A Review. JAMA. 2020; 324(8):782-93.
18 Iyer M, Jayaramayaa K, Subramaniam M, et al. COVID-19: an update on diagnostic and therapeutic approaches. BMB Rep. 2020; 53(4): 191–205.
19 Majumder MS, Mandl KD. Early in the epidemic: impact of preprints on global discourse about COVID-19 transmissibility. Lancet Glob Health 2020; 8(5): 627-30
20 Buheji M, Buheji AR. Designing Intelligent System for Stratification of COVID-19 Asymptomatic Patients. American Journal of Medicine and Medical Sciences 2020;10(4): 246-57
21 Cohen E. Infected people without symptoms might be driving the spread of coronavirus more than we realized. CNN.com. 2020 https://edition.cnn.com/2020/03/14/health/coronavirus-asymptomatic-spread/index.html.
22 Wu JT, Leung K, Leung GM. Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study. The Lancet 2020; 395: 689-97.
23 Yu P, Zhu J, Zhang Z, Han Y. A familial cluster of infection associated with the 2019 novel coronavirus indicating possible person-to-person transmission during the incubation period. J Infect Dis 2020; 221(11):1757-61.
24 Guan W, Ni Z, Hu Y, et al. Clinical characteristics of 2019 novel coronavirus infection in China. N Eng J Med 2020; 382:1708-20.
25 Thakur S, Srivastava N.Nutraceuticals : A Review. Asian J. Res. Pharm. Sci. 2016; 6(2): 85-94.
26 Soares ADN, Costa KA, Wanner SP, et al. Dietary glutamine prevents the loss of intestinal barrier function and attenuates the increase in core body temperature induced by acute heat exposure. Br. J. Nutr. 2014, 112(10), 1601–10.
27 Gadge SS.Antiviral and Immunity-modulating Natural Herbs in the Prevention of COVID-19. Research Journal of Pharmacognosy and Phytochemistry. 2021; 13(2):81-4
28 Derouiche S. Current Review on Herbal Pharmaceutical improve immune responses against COVID-19 infection. Res. J. Pharma. Dosage Forms and Tech.2020; 12(3):181-184.
29 Sporn MB, Dunlop NM, Newton DL. Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids). Fed. Proc. 1976; 35: 1332-8.
30 Patel VK, Patel CK, Patel HU, et al. Vitamins, Minerals and Carotenoids as Antioxidants. Asian J. Research Chem. 2020; 3(2):255-260.
31 Tanumihardjo SA. Vitamin A: Biomarkers of nutrition for development. Am. J. Clin. Nutr. 2011; 94 (2): 658S–65S.
32 Senoo H, Yoshikawa K, Morii M, et. al. Hepatic stellate cell (vitamin A-storing cell) and its relative—Past, present and future. Cell Biol. Int. 2010; 34: 1247–1272.
33 Retinol|C20H30O—PubChem. June 2021 available on https://pubchem.ncbi.nlm.nih.gov/compound/Retinol
34 Paiva SAR, Godoy I, Vannucchi H, et al. Assessment of vitamin A status in chronic obstructive pulmonary disease patients and healthy smokers. Am. J. Clin. Nutr. 1996; 64: 928–34.
35 Arora P, Kumar V, Batra S. Vitamin A status in children with asthma. Pediatr. Allergy Immunol. 2002; 13: 223–6.
36 Green HN Mellanby E. Vitamin a as an anti-infective agent. Br. Med. J. 1928; 2: 691–6.
37 European Union. EU Register on Nutrition and Health Claims 2020 available on https://ec.europa.eu/food/safety/labelling_nutrition/claims/register/public.
38 Calder PC, Carr AC, Gombart AF, et al. Optimal nutritional status for a well-functioning immune system is an important factor to protect against viral infections. Nutrients 2020; 12(4): 1181.
39 Kishimoto K, Kobayashi R, Sano H, et al. Impact of folate therapy on combined immunodeficiency secondary to hereditary folate malabsorption. Clin. Immunol. 2014; 153: 17–22.
40 Vogiatzoglou A, Refsum H, Johnston C, et al. Vitamin B12 status and rate of brain volume loss in community-dwelling elderly. Neurology 2008; 71: 826–32.
41 Serseg T, Benarous K, Yousfi M. Hispidin and lepidine E: Two natural compounds and folic acid as potential inhibitors of 2019-novel coronavirus Main Protease (2019-nCoVMpro), molecular docking and SAR study. Curr. Comput. Aided. Drug Des. 2020.
42 Padayatty SJ, Levine M. Vitamin C: The known and the unknown and Goldilocks. Oral Dis. 2016; 22: 463–93.
43 Wang Y, Russo TA, Kwon O, et al. Ascorbate recycling in human neutrophils: Induction by bacteria. Proc. Natl. Acad. Sci. USA 1997; 94: 13816–19.
44 Thomas WR, Holt PG. Vitamin C and immunity: An assessment of the evidence. Clin. Exp. Immunol. 1978; 32: 370–79.
45 Webb AL, Villamor E. Update: Effects of antioxidant and non-antioxidant vitamin supplementation on immune function. Nutr. Rev. 2007; 65: 181–217.
46 Ziegler HW, Sternsdorf T, Liese J, et al. Pyrrolidine dithiocarbamate inhibits NF-_B mobilization and TNF production in human monocytes. J. Immunol. 1993; 151(12): 6986–993.
47 Lo SK, Janakidevi K, Lai L, et al. Hydrogen peroxide-induced increase in endothelial adhesiveness is dependent on ICAM-1 activation. Am. J. Physiol. Lung Cell. Mol. Physiol. 1993; 264: L406–L412.
48 Senses H. Vitamin C Effective Against COVID-19: Expert; Anadolu Agency: Ankara, Turkey, 2020.
49 Australian Government. No Evidence to Support Intravenous High-Dose Vitamin C in the Management of COVID-19; Therapeutic Goods Administration: Symonston, Australia, 2020.
50 Mahmoudi M, Rezaei N. Nutrition and Immunity; Springer: Berlin/Heidelberg, Germany, 2019.
51 Lips P, Van Schoor NM. The effect of vitamin D on bone and osteoporosis. Best Pract. Res. Clin. Endocrinol. Metab. 2011; 25: 585–91.
52 Bikle DD. Chemistry&biology review vitamin D metabolism, mechanism of action, and clinical applications. Chem. Biol. 2014; 21: 319–329.
53 Grant WB, Lahore H, McDonnell SL,et al. Evidence that vitamin D supplementation could reduce risk of influenza and covid-19 infections and deaths. Nutrients 2020; 12: 988.
54 Jovic TH, Ali SR, Ibrahim N, et al. Could Vitamins Help in the Fight Against COVID-19. Nutrients 2020; 12: 2550
55 Bieri JG, Corash L, Van Hubbard S. Medical Uses of Vitamin, E. N. Engl. J. Med. 1983; 308: 1063–71.
56 Meydani SN, Leka LS, Fine BC, et al. Vitamin E and respiratory tract infections in elderly nursing home residents: A randomized controlled trial. J. Am. Med. Assoc. 2004; 292: 828–36.