Author(s): Smita Kolhe, Praveen Chaudhari, Dhananjay More

Email(s): smitamore92@gmail.com

DOI: Not Available

Address: Smita Kolhe1*, Dr. Praveen Chaudhari2, Dhananjay More3
1P.E.S’s, Modern College of Pharmacy (For Ladies), Moshi, Pune, Ms, India
2P.E.S’s, Modern College of Pharmacy, Nigdi, Pune, Ms, India
3Emcure Pharmaceuticals Limited, Bhosari, Pune, Ms, India
*Corresponding Author

Published In:   Volume - 3,      Issue - 4,     Year - 2013


ABSTRACT:
Hot melt extrusion is the most widely applied technique of solubility enhancement, includes complex mixtures of API, plastisizers and polymer carriers which are passed through single or twin-screw extruders at high temperature and stress. Present investigation deals with enhancement of dissolution rate and hence solubility of Lamotrigine, belonging to BCS class II, used primarily for treatment of Epilepsy. Copovidone as polymer and polyethylene glycol, polyoxy 35 castor oil and sorbiton monolaurate as plasticizers were used. Evaluation techniques like saturation solubility, effect of temperature on preparation of complexes, differential scanning calorimetry, x-ray diffraction, Infra red, dissolution and in vitro permeability studies were carried out. X-ray diffraction concluded that hot melt extrusion process demolished the sharp peaks of lamotrigine indicating complete conversion of crystal form to amorphous form. Dissolution and solubility studies showed enhancement in release rate. Stability studies at 40 º C/75 % RH were studied, samples were found to be stable even after 3 months study.


Cite this article:
Smita Kolhe, Praveen Chaudhari, Dhananjay More. Formulation Development of Solid Dispersion Prepared by Newer Approach: A Research. Asian J. Pharm. Res. 3(4): Oct. - Dec.2013; Page 172-180.


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Asian Journal of Pharmaceutical Research (AJPRes.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. AJPRes. publishes Original Research Articles, Short Communications..... Read more >>>

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DOI: 10.5958/2231–5691 


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