Author(s):
Hiral S. Popaniya, Payal N. Vaja, Chintankumar J. Tank
Email(s):
hiral.popaniya@dsuni.ac.in
DOI:
10.52711/2231-5691.2024.00045 
Address:
Hiral S. Popaniya1*, Payal N. Vaja2, Chintankumar J. Tank3
1Assistant Professor, School of Pharmacy, Dr. Subhash University, Junagadh (362001), Gujarat, India.
2Assistant Professor, School of Pharmacy, Dr. Subhash University, Junagadh (362001), Gujarat, India.
3Professor, School of Pharmacy, Dr. Subhash University, Junagadh (362001), Gujarat, India.
*Corresponding Author
Published In:
Volume - 14,
Issue - 3,
Year - 2024
ABSTRACT:
Melasma is a common skin problem causes brown to grey-brown patches on the several parts of face such as cheeks, chin, Nose Bridge, forehead, and above the upper lip. It is characterized as increased production and accumulation of melanin, which could be unfavourable and develops serious skin diseases. Finding natural depigmenting agents is necessary because many synthetic agents now on the market have a number of unfavourable side effects. In traditional Ayurvedic medicinal plants have been used for the treatment of skin diseases such as hyperpigmentation, melasma, age spot etc. In this study herbal medicines, for the treatment of melasma were searched in references, with their scientific names and chemical constituents showing depigmentation effect of these plants or their isolated compounds, with different melanogenesis and tyrosinase inhibition mechanism. This activity reviews the herbal plant used in melasma and highlights the role of plants constitutes responsible for treatment of melasma.
Cite this article:
Hiral S. Popaniya, Payal N. Vaja, Chintankumar J. Tank. Tyrosinase Inhibition: A Potent Mechanism of Action of Plants used in Treatment of Melasma. Asian Journal of Pharmaceutical Research. 2024; 14(3):289-4. doi: 10.52711/2231-5691.2024.00045
Cite(Electronic):
Hiral S. Popaniya, Payal N. Vaja, Chintankumar J. Tank. Tyrosinase Inhibition: A Potent Mechanism of Action of Plants used in Treatment of Melasma. Asian Journal of Pharmaceutical Research. 2024; 14(3):289-4. doi: 10.52711/2231-5691.2024.00045 Available on: https://asianjpr.com/AbstractView.aspx?PID=2024-14-3-14
REFERENCE:
1. Banna H. Hasan N. Lee J. Kim J. Cao J. Lee EH. et al. In vitro and in vivo evaluation of MHY908-loaded nanostructured lipid carriers for the topical treatment of hyperpigmentation. Journal of Drug Delivery Science and Technology. 2018; 48:457-65. doi.org/10.1016/j.jddst.2018.10.032
2. Picardo M, Carrera M. New and experimental treatments of cloasma and other hypermelanoses. Dermatologic Clinics. 2007 Jul 1; 25(3):353-62. doi.org/10.1016/j.det.2007.04.012
3. Nieuweboer‐Krobotova L. Hyperpigmentation: types, diagnostics and targeted treatment options. Journal of the European Academy of Dermatology and Venereology. 2013 Jan; 27:2-4. doi.org/10.1111/jdv.12048
4. Goswami P, Sharma HK. Skin hyperpigmentation disorders and use of herbal extracts: a review. Current Trends in Pharmacy Research 2020; 7(2):81-104.
5. Sarkar SB, Sarkar S, Ghosh S, Bandyopadhyay S. Addison's disease. Contemporary Clinical Dentistry. 2012 Oct; 3(4):484. doi: 10.4103/0976-237X.107450
6. Kannan R, Ng MJ. Cutaneous lesions and vitamin B12 deficiency: an often-forgotten link. Canadian Family Physician. 2008 Apr 1; 54(4):529-32.
7. Afnan Q, Kaiser PJ, Rafiq RA, Nazir LA, Bhushan S, Bhardwaj SC, Sandhir R, Tasduq SA. Glycyrrhizic acid prevents ultraviolet‐B‐induced photodamage: a role for mitogen‐activated protein kinases, nuclear factor kappa B and mitochondrial apoptotic pathway. Experimental Dermatology. 2016 Jun; 25(6):440-6. doi.org/10.1111/exd.12964
8. Mapunya MB, Nikolova RV, Lall N. Melanogenesis and antityrosinase activity of selected South African plants. Evidence-Based Complementary and Alternative Medicine. 2012 Jan 1; 2012.https://doi.org/10.1155/2012/374017
9. Duraisamy A, Narayanaswamy N, Balakrishnan KP. Antioxidant and anti-tyrosinase activity of some medicinal plants. Research Journal of Pharmacognosy and Phytochemistry. 2011; 3(2):86-90.
10. Mohanasrinivasan V, Saranya D, Sumitha V, Kalpana R, Nivetha A. Studies on bioactive compounds and therapeutic potential of Terminalia chebula seed extract. Research Journal of Pharmacy and Technology. 2018; 11(5):1889-93.
11. Zolghadri S, Bahrami A, Hassan Khan MT, Munoz-Munoz J, Garcia-Molina F, Garcia-Canovas F, Saboury AA. A comprehensive review on tyrosinase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry. 2019 Jan 1; 34(1):279-309. doi.org/10.1080/14756366.2018.1545767
12. Gediya SK, Mistry RB, Patel UK, Blessy M, Jain HN Herbal plants: used as a cosmetics. Journal of Natural Product and Plant Resources, 2011 1(1):24–32
13. Miot LD, Miot HA, Silva MG, Marques ME. Physiopathology of melasma. Anais Brasileiros de Dermatologia. 2009; 84:623-35. doi.org/10.1590/S0365-05962009000600008
14. Ikino JK, Nunes DH, Silva VP, Fröde TS, Sens MM. Melasma and assessment of the quality of life in Brazilian women. Anais brasileiros de dermatologia. 2015 Mar; 90:196-200.
15. Lee AY. An updated review of melasma pathogenesis. Dermatologica Sinica. 2014; 32(4):233-9. https://doi.org/10.1016/j.dsi.2014.09.006
16. Kwon SH, Na JI, Huh CH, Park KC. A clinical and biochemical evaluation of a temperature-controlled continuous non-invasive radiofrequency device for the treatment of melasma. Annals of Dermatology. 2021 Dec; 33(6):522. doi: 10.5021/ad.2021.33.6.522
17. Mahdalena I, Jusuf NK, Putra IB. Melasma characteristic in hormonal contraceptive acceptors at Kelurahan Mangga Kecamatan Medan Tuntungan, Medan-Indonesia. Bali Medical Journal. 2018 Oct 3; 7(3). doi.org/10.15562/bmj.v7i3.1000
18. Pigmentation of melasma on the face available at- https://www.powerofpositivity.com/melasma-causes-signs-decrease/
19. Kokate C. K. Purohit A. P. Gokhale S. B. Pharmacognosy Nirali Prakashan 52nd Edition. (9.9-9.16).
20. https://www.medchemexpress.com/aloesin.html
21. Afnan Q, Kaiser PJ, Rafiq RA, Nazir LA, Bhushan S, Bhardwaj SC, Sandhir R, Tasduq SA. Glycyrrhizic acid prevents ultraviolet‐B‐induced photodamage: a role for mitogen‐activated protein kinases, nuclear factor kappa B and mitochondrial apoptotic pathway. Experimental Dermatology. 2016 Jun; 25(6):440-6. doi.org/10.1111/exd.12964
22. Bean MF, Abramson D. Extraction, purification and identification of Aloe gel from Aloe vera (Aloe barbadensis Miller). Journal of Natural Products. 2009 5(3):111– 115
23. Gupta SD, Masakapalli SK. Mushroom tyrosinase inhibition activity of Aloe vera L. gel from different germplasms. Chinese Journal of Naural Medicines. 2013 Nov 1; 11(6):616-20.https://doi.org/10.1016/S1875-5364(13)60071-0
24. Choi S, Park YI, Lee SK, Kim JE, Chung MH. Aloesin inhibits hyperpigmentation induced by UV radiation. Clinical and Experimental Dermatology. 2002 Sep 1; 27(6):513-5. doi.org/10.1046/j.1365-2230.2002.01120.x
25. Tan LF, Mogana R, Chinnappan S, Venkatalakshmi R, Yap VL. Various plants and bioactive constituents for pigmentation control: A review. Research Journal of Pharmacy and Technology. 2021; 14(11):6106-12
26. Abhijit Ray. Scope of Aloe vera as Medicinal Plant and Skin Care. Res. J. Topical and Cosmetic Sci. 2012; 3(1): 1-3
27. Kokate C. K. Purohit A. P. Gokhale S. B. Pharmacognosy Nirali Prakashan 52nd Edition. (10.4-10.5).
28. https://en.wikipedia.org/wiki/Vitamin_C
29. Variya BC, Bakrania AK, Patel SS. Emblica officinalis (Amla): A review for its phytochemistry, ethnomedicinal uses and medicinal potentials with respect to molecular mechanisms. Pharmacological Research. 2016 Sep 1; 111:180-200. doi.org/10.1016/j.phrs.2016.06.013
30. Arivukkarasu R, Rajasekaran A. Detection and Quantification of Anti-oxidant markers like Rutin, Catechin, Quercetin, Gallic acid, Ellagic acid, Ferulic acid, Vitexin and Mangiferin in Herbal raw materials available in market belongs to Rutaceae family by HPTLC Technique. Asian Journal of Pharmaceutical Analysis. 2021; 11(2):151-5
31. Kumar SB. Dhanraj. M. Role of Vitamin C in Body Health. Research Journal of Pharmacy and Technology. 2018; 11(4)
32. Sripanidkulchai B, Junlatat J. Bioactivities of alcohol based extracts of Phyllanthus emblica branches: antioxidation, antimelanogenesis and anti-inflammation. Journal of Natural Medicines. 2014 Jul; 68:615-22.https://doi.org/10.1007/s11418-014-0824-1
33. Kokate C. K. Purohit A. P. Gokhale S. B. Pharmacognosy Nirali Prakashan 52nd Edition. (10.16-10.18).
34. https://en.wikipedia.org/wiki/Catechin
35. Anurukvorakun O, Boonruang R, Lahpun N. Formulation strategy, stability issues, safety and efficacy evaluations of Acacia catechu whitening cream. International Journal of Applied Pharmaceutics. 2019 11(2): 91–96
36. Kokate C. K. Purohit A. P. Gokhale S. B. Pharmacognosy Nirali Prakashan 52nd Edition. (15.74-15.75).
37. https://en.wikipedia.org/wiki/Epigallocatechin_gallate
38. Kim YC, Choi SY, Park EY. Anti-melanogenic effects of black, green, and white tea extracts on immortalized melanocytes. Journal of Veterinary Science. 2015 Jun 1; 16(2):135-43. doi.org/10.4142/jvs.2015.16.2.135
39. Sato K, Toriyama M Depigmenting effect of catechins. Molecules 2009 14(11):4425–4432. https://doi.org/10.3390/molecules14114425
40. Jo YH, Yuk HG, Lee JH, Kim JC, Kim R, Lee SC. Antioxidant, tyrosinase inhibitory, and acetylcholinesterase inhibitory activities of green tea (Camellia sinensis L.) seed and its pericarp. Food Science and Biotechnology. 2012 Jun; 21:761-8.
41. Kundu A, Mitra A. Evaluating tyrosinase (monophenolase) inhibitory activity from fragrant roots of Hemidesmus indicus for potent use in herbal products. Industrial Crops and Products. 2014 Jan 1; 52:394-9.doi.org/10.1016/j.indcrop.2013.1 0.053
42. Chakrabortty S, Choudhary R. Hemidesmus Indicus (Anantmool): rare herb of Chhattisgarh. Indian Journal of Scientific Research. 2014 4(1):89–93
43. https://spectrabase.com/compound/Jx7rAZgXKfk
44. Gupta SK, Gautam A, Kumar S. Natural skin whitening agents: a current status. Advance in Biological Research. 2014; 8(6):257–259
45. Kokate C. K. Purohit A. P. Gokhale S. B. Pharmacognosy Nirali Prakashan 52nd Edition. (9.63-9.67).
46. https://en.wikipedia.org/wiki/Glabridin
47. Couteau C, Coiffard L. Overview of skin whitening agents: drugs and cosmetic products. Cosmetics. 2016 3(3):27. https://doi.org/10.3390/cosmetics303 0027
48. Nerya O, Vaya J, Musa R, Izrael S, Ben-Arie R, Tamir S. Glabrene and isoliquiritigenin as tyrosinase inhibitors from licorice roots. Journal of Agricultural and Food Chemistry. 2003 51(5):1201–1207. https://doi.org/10.1021/jf020935u
49. https://en.wikipedia.org/wiki/Nuciferine
50. Huang B, Zhu L, Liu S, Li D, Chen Y, Ma B, Wang Y. In vitro and in vivo evaluation of inhibition activity of lotus (Nelumbo nucifera Gaertn.) leaves against ultraviolet B-induced phototoxicity. Journal of Photochemistry and Photobiology B: Biology. 2013 121:1–5. https://doi.org/10.1016/j.jphotobiol.2013.02.005
51. https://www.medchemexpress.com/Azoramide.html
52. Sable Namita V., Pagar Swati A. A review on Lotus: use in herbal cosmetics. Res. J. Topical and Cosmetic Sci. 2013; 4(1): 81-83.
53. Kokate C. K. Purohit A. P. Gokhale S. B. Pharmacognosy Nirali Prakashan 52nd Edition. (11.30).
54. Chiocchio I, Mandrone M, Sanna C, Maxia A, Tacchini M, Poli F. Screening of a hundred plant extracts as tyrosinase and elastase inhibitors, two enzymatic targets of cosmetic interest. Industrial Crops and Products. 2018; 12: 498–505
55. https://www.selleckchem.com/products/papain.html
56. Rodrigo UD, Perera BGK Important biological activities of papaya peel extracts and their importance in formulation of a low cost fish feed to enhance the skin colour and the healthiness of guppies. International Journal of Scientific and Research Publications. 2018; 8(12):702–708
57. Song Y, Jeong SW, Lee WS, Park S, Kim YH, Kim GS et al. Determination of polyphenol components of Korean prostrate spurge (Euphorbia supina) by using liquid chromatography–tandem mass spectrometry: Overall contribution to antioxidant activity. Journal of Analytical Methods in Chemistry. 2014: 1–8
58. https://en.wikipedia.org/wiki/Picrocrocin
59. Kokate C. K. Purohit A. P. Gokhale S. B. Pharmacognosy Nirali Prakashan 52nd Edition. (14.105-14.107).
60. Chakrabortty S, Choudhary R. Hemidesmus Indicus (Anantmool): rare herb of Chhattisgarh. Indian Journal of Scientific Research. 2014; 4(1): 89–93
61. Li CY, Wu TS. Constituents of the pollen of Crocus sativus L. and their tyrosinase inhibitory activity. Chemical and Pharmaceutical Bulletin. 2002; 50(10):1305–1309
62. https://commons.wikimedia.org/wiki/File:Alpha Santalol_Structural_Formula_V1.svg
63. Kokate C. K. Purohit A. P. Gokhale S. B. Pharmacognosy Nirali Prakashan 52nd Edition. (14.91-14.94).
64. Moy RL, Levenson C. Sandalwood album oil as a botanical therapeutic in dermatology. The Journal of Clinical and Aesthetic Dermatology. 2017; 10(10):34–39
65. Bhowmik D, Biswas D, Kumar KP. Recent aspect of ethnobotanical application and medicinal properties of traditional Indian Herbs Santalum album. International Journal of Current Research. 2011; 1:21–27
66. https://commons.wikimedia.org/wiki/File:Curcumin_structure.svg
67. Kokate C. K. Purohit A. P. Gokhale S. B. Pharmacognosy Nirali Prakashan 52nd Edition. (14.135-14.137).
68. Mukherjee PK, Biswas R, Sharma A, Banerjee S, Biswas S, Katiyar CK. Validation of medicinal herbs for anti-tyrosinase potential. Journal of Herbal Medicine. 2018; 14: 1–16. https://doi.org/10.1016/j.hermed.2018.09.002
69. Du ZY, Jiang YF, Tang ZK, Mo RQ, Xue GH, Lu YJ et al Antioxidation and tyrosinase inhibition of polyphenolic curcumin analogs. Bioscience, Biotechnology, and Biochemistry, 2011; 75(12): 2351–2358. https://doi.org/10.1271/bbb.110547
70. Jang JY, Lee JH, Jeong SY, Chung KT, Choi YH, Choi BT. Partially purified Curcuma longa inhibits alpha-melanocyte-stimulating hormonestimulated melanogenesis through extracellular signal-regulated kinase or AKT activation-mediated signalling in B16F10 cells. Experimental Dermatology. 2009; 18(8): 689–694. https://doi.org/10.1111/j.1600-0625.2009.00857.
71. Deni Firmansyah, Sulistiorini Indriaty, Sri Adi Sumiwi, Nyi Mekar Saptarini, Jutti Levita. Microphthalmia Transcription Factor almost Thirty Years after: Its Role in Melanogenesis and its Plant-Derived Inhibitors. Research Journal of Pharmacy and Technology. 2022; 15(6): 2825-0. doi: 10.52711/0974-360X.2022.00472
72. Sabale P, Modi A, Sabale V. Curcuma longa Linn. A phytochemical and phytopharmacological review. Research Journal of Pharmacognosy and Phytochemistry. 2013; 5(2):59-68.
73. Azhar-Ul-Haq MA, Khan MTH, Anwar-Ul-Haq KSB, Ahmad A et al. Tyrosinase inhibitory lignans from the methanol extract of the roots of Vitex negundo Linn. and their structure-activity relationship. Phytomedicine. 2006; 13(4): 255–260. https://doi.org/10.1016/j.phymed.2004.09.001
74. Smit N, Vicanova J, Pavel S. The hunt for natural skin whitening agents. International Journal of Molecular Sciences. 2009; 10(12): 5326–5349. https://doi.org/10.3390/ijms10125326
75. https://en.wikipedia.org/wiki/Beta-Sitosterol
76. Ge L, Zhang W, Zhou G, Ma B, Mo Q, Chen Y et al. Nine phenylethanoid glycosides from Magnolia officinalis var. biloba fruits and their protective effects against free radical-induced oxidative damage. Scientific Reports. 2017; 7:2–13.
77. Kamagaju L, Bizuru E, Minani V, Morandini R, Stévigny C, Ghanem G, Duez P. An ethnobotanical survey of medicinal plants used in Rwanda for voluntary depigmentation. Journal of Ethnopharmacology. 2013; 150(2):708–717
78. Couteau C, Coiffard L. Overview of skin whitening agents: drugs and cosmetic products. Cosmetics. 2013; 3(3): 27. https://doi.org/10.3390/cosmetics303 0027
79. Lee SH, Choi SY, Kim H, Hwang JS, Lee BG, Gao JJ, Kim SY Mulberroside F isolated from the leaves of Morus alba inhibits melanin biosynthesis. Biological and Pharmaceutical Bulletin. 2002; 25(8): 1045–1048. https://doi.org/10.1248/bpb.2 5.1045
80. Shivhare SC, Malviya KG, Malviya KS, Jain V. A Review: Natural skin lighting and nourishing agents. Research Journal of Topical and Cosmetic Sciences. 2013; 4(1)