Author(s):
Malay Paul, H. S Keerthy, Mukesh Sharma, Pradeep Kumar Patel, Sowmya TP
Email(s):
paulmalay550@gmail.com
DOI:
10.52711/2231-5691.2023.00031 
Address:
Malay Paul*, H. S Keerthy, Mukesh Sharma, Pradeep Kumar Patel, Sowmya TP
Department of Pharmaceutics, Mallige College of Pharmacy, Bangalore – 560090.
*Corresponding Author E-mail:
Published In:
Volume - 13,
Issue - 3,
Year - 2023
ABSTRACT:
Microspheres play a totally critical function as a particulate drug transport machine due to theirtiny size and different properties. Microspheres proved an appropriate bridge to scale the gap over to formulate a powerful dosage form, to managed drug release, to simulate controlled drug release. Microspheres are often free-flowing stable powders, which include proteins or artificial polymers, which can be biodegradable. Microspheres having a particle size in the range of 0.1-800µm, can be delivered by several routes like oral, parenteral, nasal, ophthalmic, transdermal, colonal, etc. Various recent advancements in the case of microspheres like mucoadhesive, hollow, floating, micro balloons, and magnetic have contributed to overcoming the diverse troubles which might be related to using microspheres, which incorporates site-precise focused on and stepped forward release. In the future by combining various new designing, planning’s, and strategies, microspheres will find a central place in novel drug delivery, especially in diseased molecular sorting, genetic materials, safe, targeting, and powerful drug delivery.
Cite this article:
Malay Paul, H. S Keerthy, Mukesh Sharma, Pradeep Kumar Patel, Sowmya TP. A Review on Microspheres as Controlled Release Drug Delivery. Asian Journal of Pharmaceutical Research. 2023; 13(3):163-8. doi: 10.52711/2231-5691.2023.00031
Cite(Electronic):
Malay Paul, H. S Keerthy, Mukesh Sharma, Pradeep Kumar Patel, Sowmya TP. A Review on Microspheres as Controlled Release Drug Delivery. Asian Journal of Pharmaceutical Research. 2023; 13(3):163-8. doi: 10.52711/2231-5691.2023.00031 Available on: https://asianjpr.com/AbstractView.aspx?PID=2023-13-3-5
REFERENCES:
1. Jha MK: Modified release formulations to achieve the quality target product profile (QTPP). Int.J. Pharm.Sci. Res. 2012; 3(2): 376-86.
2. Prasanth V, Moy V, and Chakraborthy A et al: Microspheres: An overview. Int. J. Pharm. Sci. Res. Biomed. Sci. 2011; 2(3): 32-8.
3. Fu X, Ping Q and Gao Y. Effects of formulation factor on encapsulation efficiency and release behavior in-vitro of huperzine A-PLGA microspheres. J. Microencapsul. 22: 705-14.
4. Ghalop SB, Banerjee SK and Throat RM et al: Hollow microsphere a Review. Int. J. Pharm. Sci. Rev. Res. 2010; 1:10-15.
5. Kavita K, RajeV, et al. Albumin Microspheres: A Unique system as drug delivery carriers for nonsteroidal anti-inflammatory drugs. 2012; 5(2):12
6. Asija R, Sharma D, and Mall KR: Solvent evaporation matrix erosion method: a novel approach for floating microsphere development. Drug Discov. Ther. 2014; 2: 24-9.
7. Kunchu K and Ashwani RV et al: Albumin microspheres: An Unique System as Drug Delivery Carriers for nonsteroidal anti-inflammatory drugs (NSAIDS). Int. J. Pharm. Sci. Rev. Res. 2010; 5:10-17.
8. CA 2579533, Andrew Lennard Lewis Peter William Stratford Maria Victoria Gonzalez-Fajardo Yiqing Tang, Publication: 06-09-05.
9. DE1999609777, S. Adam CANTOR Hye-Ok Choi Joaquin Delgado U. Chan KOThu-Van Tran, Publication: 15-04-04.
10. CA 2217462, Zebunnissa Ramtoola, Publication: 03-08- 10
11. EP20070808011, Hong KeeSah, Publication: 03-04-13
12. DE1994632867, Yan Chen Bruce Nathaniel Gray, Publication: 22-04-04
13. CN 201110142359, Zhu Limin Sciascia Nie Shen Wei, Publication: 28-09-11
14. US08455091, Rocio Herrero-Vanrell Miguel F. Refojo, Publication: 17-02-98
15. Kataria S, Midha A and Sandhu P et al: Microsphere A review. Int. J. Res. Pharm. Chem. 2011; 1:1184-98.
16. Kunchu K and Ashwani RV et al: Albumin microspheres: An Unique System as Drug Delivery Carriers for nonsteroidal anti-inflammatory drugs (NSAIDS). Int. J. Pharm. Sci. Rev. Res. 2010; 5:10-17.
17. Prasanth VV, Moy AC, Mathew ST, Mathapan R, Microspheres: an overview, Int. J. Res. Pharm. Biomed. Sci. 2011; 2(2): 332-8.
18. Boggarapu Prakash Rao, Rashmi Mathews, Karedla Phani Krishna, Beny Baby, and Poornima, Spray-dried gastroretentive floating microparticles: Preparation and in vitro evaluation, Pak. J. Pharm. Sci. 2013;26(4), 707-13.
19. Priya P, Sivabalan M, Balaji M, Rajashree S, Muthu DH, Microparticle: a novel drug delivery system, Int. J. Pharma Bio Sci. 2013; 3(2):310-26.
20. Chitra Singh, Suresh Purohit, Madhu Singh, B.L. Pandey, Design, and Evaluation of microspheres: a review. Journal of Drug Delivery Research. 2013; 2(2): 18-26.
21. Soni LM, Kumar M, Namdeo PK, Sodium alginate Microspheres for extending drug release: formulation and in vitro evaluationInt. J. Drug Deliv. 2010; 2(1):64-8.
22. Ramteke KH, Jadhav VB, Dhole SN, Microspheres: as carriers used for novel drug delivery system. IOSR Journal of Pharmacy. 2012;2(4): 44-8.
23. Bhalerao S.S., Lalla J.K., Rane M.S. A study of electrokinetic and stability property of suspension of diltiazem hydrochloride microcapsule. Indian Drugs. 2001; 38: 464-467.
24. Chowdary K.P., Ramesh K.V. Studies on microencapsulation of diltiazem, J. Pharm. Sci. 1993; 55:52-4.
25. Reddy M.N., Shriwaikar A.A. Rosin. A polymer for microencapsulation of diltiazem hydrochloride for sustained release by emulsion-solvent evaporation technique. Indian J. Pharm. Sci. 2000; 62:308-10.
26. Alexander Florence. Novel oral drug formulations: Their potential in modulating adverse effects. Drug Safety. 1994; 10(3): 233-66.
27. Arshady R. Albumin microsphere and microcapsule; methodology of manufacturing techniques. J Controlled Release. 1990; 111-31.
28. Kim CK, Kim MJ, Oh KH. Preparation and evaluation of sustained-release microspheres of terbutaline sulfate. Int J Pharm. 1994; 213-19.
29. Lorenzo-Lamosa ML. Design of microencapsulated chitosan microspheres for colon drug delivery. J Control Release. 1998; 52(12):109-18.
30. Wan LSC, Heng PWS, Chan W. Surfactant effects on alginate microspheres. Int J Pharm. 1994; 267–75.
31. Kreuter J, Nefzger M, Liehl E, CzokR, Voges R. Microspheres – A Novel Approach in Drug Delivery System. J Pharm Sci. 1983; 72: 1146.
32. Paulo Costa, Jose Manuel Sousa Lobo, Modelling and comparison of dissolution profiles. European Journal of Pharmaceutical Sciences. 2001; 13: 123- 33.
33. Keys, H.M., Bundy, B.N., Stehman, F.B., Muderspach, L.I., Chafe, W.E., Suggs, C.L., Walker, J.L., and Gersell, D. Cisplatin, radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical carcinoma. The New England J of Medicine. 1999; 340: 1154- 61.
34. Nithya Shanthi C, Rakesh Gupta, Arun Kumar Mahato. Traditional and emerging applications of microspheres: A Review. Int. J. Pharm. Tech. Res. 2010; 2(1), 675-81.
35. Soni LM, Kumar M, Namdeo PK. Sodium alginate Microspheres for extending drug release: formulation and in vitro evaluation. International Journal of Drug Delivery. 2010; 2(1):64-8.
36. Pradesh TS, Sunny CM, Varma KH, Ramesh P. Preparation of microstructured by droxyapatite microspheres using oil in water emulsion. Bull Matter. Sci. 2005; 28(5):383-90.
37. Asija Rajesh, Bansal Vishnu, Asija Sangeeta, Rathore Suryabhan Singh. Matrix Tablet: A Promising Tool for Oral Controlled Release Drug Delivery. Asian J. Pharm. Res. 2013; 3(4): 213-9.
38. Atul Bisen, Alok Pal Jain, Suchit Jain. Formulation and Evaluation of Zidovudine Loaded Microsphere. Asian J. Res. Pharm. Sci. 2013; 3(4): 200-5.
39. Pooja M. Nikam, S.B. Gondkar, R.B. Saudagar. Brain Targeting Drug Delivery System: A Review. Asian J. Res. Pharm. Sci. 2015; 5(4): 247-52.
40. Kaustubh V. Gavali, Manohar D. Kengar, Kiran V. Chavan, Vaishnavi P. Anekar, Naziya I. Khan. A Review on Microsphere and it’s Application. Asian J. Pharm. Res. 2019; 9(2): 123-9.
41. Dhadde Gurunath S., Mali Hanmant S., Raut Indrayani D., Nitalikar Manoj M., Bhutkar Mangesh A. A Review on Microspheres: Types, Method of Preparation, Characterization and Application. Asian Journal of Pharmacy and Technology. 2021; 11(2):149-55.
42. Wajid Ahmad, Jaza Quazi, Reshma Khan, Nadeem Ahmad, Nawed Ansari. A Comprehensive Review on Microspheres. Asian J. Pharm. Technol. 2022; 12(2):136-40.
43. Vinod R, Ashok Kumar P, Amit S Yadav, Someshwara Rao B, Suresh V Kulkarni. Formulation and Evaluation of Controlled Release Microspheres of Zidovudine. Research J. Pharma. Dosage Forms and Tech. 2010; 2(1):96-9.
44. Rutuja K. More, Diksha S. Sonawane, Moreshwar P. Patil, Sanjay J. Kshirsagar. Rutuja K. More, Diksha S. Sonawane, Moreshwar P. Patil, Sanjay J. Kshirsagar. Res. J. Pharma. Dosage Forms and Tech. 2018; 10(3): 193-9.
45. Deepak S. Kshirsagar, R. B. Saudagar. Microsphere: A Review. Research J. Topical and Cosmetic Sci. 2016; 7(1): 27-37.
46. Katta. Manogna, E. Nanda Krishna Reddy, T.N. Shilpa. Polymeric Novel Vesicular Drug Delivery System: An Updated Overview of Microspheres. Research J. Topical and Cosmetic Sci. 2017; 8(2): 64-72.
47. VN Deshmukh, JK Jadhav, VJ Masirkar, DM Sakarkar. Formulation, Optimization and Evaluation of Controlled Release Alginate Microspheres Using Synergy Gum Blends. Research J. Pharm. and Tech. 2009; 2(2): 324-7.
48. UK Patil, Ravish Sahu, SK Yadav. Formulation and Evaluation of Controlled Release Microspheres Containing Metformin Hydrochloride. Research J. Pharm. and Tech. 2009; 2(1): 176-9.
49. Ayanam Vasavi, Miriyala Mrunalini, Ayanam Vasanthi, G. Raveendra Babu, M. Sowjanya. Formulation and Evaluation of Sustained Release Stavudine Microspheres by Ionotropic Gelation Method. Asian J. Pharm. Technol. 2022; 12(2):119-24.
50. A Saravanakumar, Sunita Minz, Madhulika Pradhan, Pavani Sure, Atul N Chandu, Umesh Mishra, K Kamalakannan, T Sivakumar.Polylactic Acid Microspheres as A Potential Vaccine Delivery System for the Tetanus Toxoid: Preparation and In Vitro Dissolution Study. Research J. Pharm. and Tech. 2008; 1(4):453-9.