Muskan M. Maniyar, Amol S. Deshmukh, Suvarna J. Shelke
Muskan M. Maniyar*, Amol S. Deshmukh, Suvarna J. Shelke
Department of Pharmaceutics, S.M.B.T. College of Pharmacy, Nandi-Hills, Dhamangaon, Nashik, India.
Volume - 12,
Issue - 3,
Year - 2022
In our five sense organs skin is the biggest organ which prevents entry of different foreign particles into the systemic circulation. For our body drug is also considered as a foreign particle hence it is difficult task to reach the drug into systemic circulation through the transdermal route without invasion. Now a day’s many novel formulations are present in the market which allows the transfer of drug through the transdermal route without invasion like liposomes, phytosomes, neosomes and ethosomes. But with the help of ethosome formulation it becomes very easy to transfer the drug into systemic circulation through the transdermal route. Large drug molecules can be delivered to site of action by ethosomes. Ethosomes are the bilayer lipid vesicles which allow the transfer of drug into the deep skin layers and into the blood. It contains large amount of ethanol and penetration enhancers are incorporated into it to enhance the rate of penetration. It contains the phospholipid bilayer with polar head and nonpolar tail. At the center ethanolic cavity is present which is filled with the hydroethanolic solution. We can incorporate all types of drug into the ethosome i.e., lipophilic, hydrophilic, and amphiphilic and this property makes it unique from other dosage forms. Further we can formulate cream, gel or patches of ethosomes. Cellutight EF, Nanominox, Noicellex, Supravir cream these are some examples of marketed ethosomal formulations. This review summarizes the types of ethosomes i.e., classical ethosomes, binary ethosomes and transethosomes. And also includes advantages, disadvantages, therapeutic applications, methods of preparation and characterization of the ethosomes.
Cite this article:
Muskan M. Maniyar, Amol S. Deshmukh, Suvarna J. Shelke. Ethosomes: A carrier for Transdermal Drug Delivery System. Asian Journal of Pharmaceutical Research. 2022; 12(3):225-8. doi: 10.52711/2231-5691.2022.00037
Muskan M. Maniyar, Amol S. Deshmukh, Suvarna J. Shelke. Ethosomes: A carrier for Transdermal Drug Delivery System. Asian Journal of Pharmaceutical Research. 2022; 12(3):225-8. doi: 10.52711/2231-5691.2022.00037 Available on: https://asianjpr.com/AbstractView.aspx?PID=2022-12-3-8
1. Grace X. Development of terminalia chebula loaded ethosomal gel for transdermal drug delivery. Asian journal of pharmaceutical and clinical research. Dec.2018;11(12):380-383. DOI:10.22159/ajpcr.2018.v11i12.20764
2. Kalra N, Choudhary S, Arora P, Arora N. Ethosomal drug delivery system: A newer approach. Asian journal of pharmaceutical research and development.2020;8(5):158-162. DOI:http://dx.doi.org/10.22270/ajprd.v8i5.835
3. Saudagar RB, Samuel S. Ethosomes: Novel noninvasive carrier for transdermal drug delivery. Asian J. Pharm. Tech. 2016;6(2):135-138. DOI:10.5958/2231-5713.2016.00019.2
4. Roge AB, Sakhare RS, Bakal RL, Channawar MA, Bakde BV, Gawnde SR, Chandewar AV. Ethosomes: Novel approach in transdermal drug delivery system. Research J. Pharma. Dosage form and Tech. 2010; 2(1):22-27.
5. Kundlik G, Patil UK. Formulation and characterization of ethosomal formulation of ciclopirox olamine. Research J. Pharma. Dosage Forms and Tech. 2012; 4(5):285-289.
6. Mishra AD, Khunt DM, Ghayal AH, Patel CN, Shah DR. Formulation and optimization of ethosomes for transdermal delivery of felodipine. Research J. Pharm. and Tech. 2012; 5(12):1509-1517.
7. Patel A, Sharma RK, Trivedi M, Shivaprakash, Panicker A. Ethosomes: A novel tool for transdermal drug delivery. Research J. Pharm. and Tech. 2013;6(8):838-841.
8. Jondhalekar TM, Aher SS, Saudagar RB. Transethosome: Novel vesicular carrier for enhanced transdermal drug delivery system. Research J. Pharm. and Tech. 2017; 10(6):1816-1819. DOI: 10.5958/0974-360X.2017.00320.1
9. Gondkar SB, Patil NR, Saudagar RB. Formulation development and characterization of etodolac loaded transethosomes for transdermal delivery. Research J. Pharm. and Tech. 2017; 10(9):3049-3057. DOI:10.5958/0974-360X.2017.00541.8
10. Pandey S, Mishra SK, Sharma N. Ethosomes- A novelize vesicular drug delivery system. Research J. Pharm. and Tech. 2017; 10(9):3223-3232. DOI:10.5958/0974-360X.2017.00572.8
11. Sahu SK, Ram A. Evaluation of linezolid loaded ethosomes for treatement of deep skin infections in diabetic model. Research J. Pharm. and Tech. 2018; 11(7):3023-3030. DOI:10.5958/0974-60X.2018.00557.7
12. Deshmukh AS, Mahale VG, Mahajan VR. Liquisolid compact techniques: A review. Research J. Dosage Forms and Tech. 2014; 6(3):161-166.
13. Pandey V, Golhani D and Shukla R. Ethosomes: versatile vesicular carriers for efficient transdermal delivery of therapeutic agents, Drug Delivery. 2015;22(8):988-1002. DOI:10.3109/10717544.2014.889777
14. Kulkarni S, Mishra KP, Sharma SB and Jain S, Ethosomes: A promising way for transdermal drug delivery, International Journal of Pharmaceutical Sciences and Research. 2015;6(9):3663-70. DOI: 10.13040/IJPSR.0975-8232.
15. Jain S, Patel N, Madan P, Lin S. Quality by design approach for formulation, evaluation and statistical optimization of diclofenac-loaded ethosomes via transdermal route. Pharm Dev Technol. 2015;20(4):473–489. DOI: 10.3109/10837450.2014.882939
16. Zhang Z, Wo Y, Zhang Y. In vitro study of ethosome penetration in human skin and hypertrophic scar tissue. Nanomedicine: Nanotechnology, Biology and Medicine. 2012;8(6):1026–1033. doi.org/10.1016/j.nano.2011.10.006
17. Mishra D, Mishra PK, Dabadghao S, Dubey V, Nahar M, Jain NK. Comparative evaluation of hepatitis B surface antigen-loaded elastic liposomes and ethosomes for human dendritic cell uptake and immune response. Nanomedicine. 2010;6(1):110-118. DOI: 10.1016/j.nano.2009.04.003
18. Hua S. Lipid-based nano-delivery systems for skin delivery of drugs and bioactives. Frontiers in pharmacology. 2015;6:219. DOI:10.3389/fphar.2015.00219
19. Sarwa KK, Suresh PK, Rudrapal M, Verma VK. Penetration of tamoxifen citrate loaded ethosomes and liposomes across human skin: a comparative study with confocal laser scanning microscopy. Current Drug Delivery. 2014;11(3):332-337.
20. Zhou Y, Wei Y, Liu H, Zhang G, Wu X. Preparation and in vitro evaluation of ethosomal total alkaloids of Sophora alopecuroidesloaded by a transmembrane pH-gradient method. American Association of Pharmaceutical Scientists. 2010;11(3):1350-1358. DOI: 10.1208/s12249-010-9509-6
21. Li G, Fan Y, Fan C, et al. Tacrolimus-loaded ethosomes: physicochemical characterization and in vivo evaluation. European Journal of Pharmaceutics and Biopharmaceutics. 2012;82(1):49-57. DOI:10.1016/j.ejpb.2012.05.011